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| | era | GTP-binding protein (era); An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (302 aa) |
| | rnc | Ribonuclease III (rnc); Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (227 aa) |
| | lepB | Signal peptidase I (lepB); Similar to GB:K00426 SP:P00803 PID:146600 PID:987643 GB:U00096 percent identity: 46.31; identified by sequence similarity; putative; Belongs to the peptidase S26 family. (349 aa) |
| | lepA | GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (598 aa) |
| | rsfS | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (102 aa) |
| | dksA | dnaK suppressor protein (dksA); Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. (145 aa) |
| | ppiB | Peptidyl-prolyl cis-trans isomerase B (ppiB); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (169 aa) |
| | HI_0094 | Predicted coding region HI0094; Hypothetical protein; identified by GeneMark; putative. (106 aa) |
| | ffh | Signal recognition particle protein (ffh); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual co [...] (462 aa) |
| | serS | seryl-tRNA synthetase (serS); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (429 aa) |
| | gst | Glutathione transferase (bphH); Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Beta family. (209 aa) |
| | ppa | Inorganic pyrophosphatase (ppa); Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. (176 aa) |
| | rpmF | Ribosomal protein L32 (rpL32); Similar to GB:M29698 SP:P02435 PID:147712 GB:U00096 PID:1651531 percent identity: 77.19; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL32 family. (56 aa) |
| | yceD | Conserved hypothetical protein; Plays a role in synthesis, processing and/or stability of 23S rRNA. (174 aa) |
| | rplS | Ribosomal protein L19 (rpL19); This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (116 aa) |
| | trmD | tRNA (guanine-N1)-methyltransferase (trmD); Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (246 aa) |
| | rimM | Conserved hypothetical protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (178 aa) |
| | rpsP | Ribosomal protein S16 (rpS16); Similar to SP:P02372 PID:43143 GB:U00096 PID:1788961 percent identity: 70.73; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bS16 family. (82 aa) |
| | pnp | Polynucleotide phosphorylase (pnp); Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (709 aa) |
| | deaD | ATP-dependent RNA helicase (deaD); DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (613 aa) |
| | arfA | Conserved hypothetical protein; Rescues ribosomes stalled at the 3' end of non-stop mRNAs. Recruits release factor 2 (RF2) to the stalled ribosome, helping position it correctly in the ribosomal A site so its GGQ motif can hydrolyze the peptidyl-tRNA bond (By similarity). (69 aa) |
| | secF | Protein-export membrane protein (secF); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (325 aa) |
| | secD | Protein-export membrane protein (secD); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (616 aa) |
| | yajC | Conserved hypothetical protein; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (97 aa) |
| | yfiA | Sigma(54) modulation protein, putative; During stationary phase, prevents 70S dimer formation, probably in order to regulate translation efficiency during transition between the exponential and the stationary phases. In addition, during environmental stress such as cold shock or excessive cell density at stationary phase, stabilizes the 70S ribosome against dissociation, inhibits translation initiation and increase translation accuracy. When normal growth conditions are restored, is quickly released from the ribosome (By similarity); Belongs to the HPF/YfiA ribosome-associated protein [...] (107 aa) |
| | rpoH | RNA polymerase sigma-32 factor (rpoH); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (281 aa) |
| | rph | Ribonuclease PH (rph); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (238 aa) |
| | gltX | glutamyl-tRNA synthetase (gltX); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (480 aa) |
| | rho | Transcription termination factor (rho); Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (420 aa) |
| | rnt | Ribonuclease T (rnt); Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis. (229 aa) |
| | rnd | Ribonuclease D (rnd); Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family. (399 aa) |
| | rluC | Conserved hypothetical protein; Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RluA family. (322 aa) |
| | rne | Ribonuclease E (rne); Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (951 aa) |
| | srmB | ATP-dependent RNA helicase (srmB); DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity; Belongs to the DEAD box helicase family. SrmB subfamily. (439 aa) |
| | HI_0424 | rRNA methylase, putative; Similar to SP:P33635 GB:U00096 PID:1788935 percent identity: 43.03; identified by sequence similarity; putative; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (351 aa) |
| | secG | Protein-export membrane protein (secG); Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family. (112 aa) |
| | atpC | ATP synthase F1, subunit epsilon (atpC); Produces ATP from ADP in the presence of a proton gradient across the membrane. (142 aa) |
| | atpD | ATP synthase F1, subunit beta (atpD); Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (457 aa) |
| | atpG | ATP synthase F1, subunit gamma (atpG); Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (289 aa) |
| | atpA | ATP synthase F1, subunit alpha (atpA); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (513 aa) |
| | atpH | ATP synthase F1, subunit delta (atpH); F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa) |
| | atpF | ATP synthase F0, subunit b (atpF); F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (156 aa) |
| | atpE | ATP synthase F0, subunit c (atpE); F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (84 aa) |
| | atpB | ATP synthase F0, subunit a (atpB); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (262 aa) |
| | HI_0485.1 | Predicted coding region HI0485.1; Brute Force ORF; identified by GeneMark; putative. (124 aa) |
| | rsmG | Glucose-inhibited division protein (gidB); Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (203 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' chain (rpoC); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1415 aa) |
| | rpoB | DNA-directed RNA polymerase, beta chain (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1343 aa) |
| | rplA | Ribosomal protein L1 (rpL1); Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa) |
| | rplK | Ribosomal protein L11 (rpL11); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (142 aa) |
| | rpsU | Ribosomal protein S21 (rpS21); Similar to GB:J01687 SP:P02379 GB:V00346 PID:147754 PID:42868 percent identity: 83.10; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bS21 family. (71 aa) |
| | rpoD | RNA polymerase sigma-70 factor (rpoD); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (629 aa) |
| | rplI | Ribosomal protein L9 (rpL9); Binds to the 23S rRNA. (149 aa) |
| | rpsR | Ribosomal protein S18 (rpS18); Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (75 aa) |
| | rpsF | Ribosomal protein S6 (rpS6); Binds together with S18 to 16S ribosomal RNA; Belongs to the bacterial ribosomal protein bS6 family. (125 aa) |
| | infA | Translation initiation factor 1 (infA); One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (84 aa) |
| | rsmA | Dimethyladenosine transferase (ksgA); Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (287 aa) |
| | gph | Phosphoglycolate phosphatase (gph); Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (224 aa) |
| | tufA | Elongation factor Tu (tufA); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (394 aa) |
| | fusA | Elongation factor G (fusA); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] (700 aa) |
| | rpsG | Ribosomal protein S7 (rpS7); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | rpsL | Ribosomal protein S12 (rps12); With S4 and S5 plays an important role in translational accuracy. (124 aa) |
| | mnmG | Glucose inhibited division protein (gidA); NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (629 aa) |
| | rsmB | Sun protein (sun); Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (451 aa) |
| | HI_0632 | Elongation factor Tu (tufB); Similar to GB:U00006 SP:P02990 GB:J01717 GB:M10459 GB:X57091 percent identity: 92.64; identified by sequence similarity; putative. (394 aa) |
| | rplJ | Ribosomal protein L10 (rpL10); Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (163 aa) |
| | rplL | Ribosomal protein L7/L12 (rpL7/L12); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (123 aa) |
| | selB | Selenocysteine-specific elongation factor (selB); Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily. (619 aa) |
| | tig | Trigger factor (tig); Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity). Belongs to the FKBP-type PPIase family. Tig subfamily. (432 aa) |
| | secE | Preprotein translocase SecE subunit (secE); Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (106 aa) |
| | nusG | Transcription antitermination protein (nusG); Participates in transcription elongation, termination and antitermination. (185 aa) |
| | proS | prolyl-tRNA synthetase (proS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and invol [...] (572 aa) |
| | secB | Protein-export protein (secB); One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (169 aa) |
| | rpmE | Ribosomal protein L31 (rpL31); Binds the 23S rRNA. (70 aa) |
| | ftsY | Cell division protein (ftsY); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (414 aa) |
| | rpsJ | Ribosomal protein S10 (rpS10); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (118 aa) |
| | rplC | Ribosomal protein L3 (rpL3); One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (208 aa) |
| | rplD | Ribosomal protein L4 (rpL4); One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). This protein when expressed in E.coli represses both transcription and translation of the endogenous S10 operon. As the H.influenzae S10 leader can be regulated in vitro by the E.coli L4 protein this strongly suggests the endogenous protein controls its own S10 operon in a sim [...] (200 aa) |
| | rplW | Ribosomal protein L23 (rpL23); One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (99 aa) |
| | rplB | Ribosomal protein L2 (rpL2); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (273 aa) |
| | rpsS | Ribosomal protein S19 (rpS19); Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (91 aa) |
| | rplV | Ribosomal protein L22 (rpL22); This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (110 aa) |
| | rpsC | Ribosomal protein S3 (rpS3); Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (235 aa) |
| | rplP | Ribosomal protein L16 (rpL16); Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (136 aa) |
| | rpmC | Ribosomal protein L29 (rpL29); Similar to SP:P55840 PID:1841330 percent identity: 90.48; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uL29 family. (63 aa) |
| | rpsQ | Ribosomal protein S17 (rpS17); One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (85 aa) |
| | rplN | Ribosomal protein L14 (rpL14); Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (123 aa) |
| | rplX | Ribosomal protein L24 (rpL24); One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (103 aa) |
| | rplE | Ribosomal protein L5 (rpL5); This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa) |
| | rpsN | Ribosomal protein S14 (rpS14); Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa) |
| | rpsH | Ribosomal protein S8 (rpS8); One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rplF | Ribosomal protein L6 (rpL6); This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa) |
| | rplR | Ribosomal protein L18 (rpL18); This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (117 aa) |
| | rpsE | Ribosomal protein S5 (rpS5); With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (166 aa) |
| | rpmD | Ribosomal protein L30 (rpL30); Similar to GB:X01563 SP:P02430 GB:M24532 PID:42987 PID:606236 percent identity: 79.66; identified by sequence similarity; putative. (59 aa) |
| | rplO | Ribosomal protein L15 (rpL15); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa) |
| | secY | Preprotein translocase SecY subunit (secY); The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (441 aa) |
| | rpmJ | Ribosomal protein L36 (rpL36); Similar to SP:P21194 GB:M12432 PID:42990 PID:606233 PID:1128970 percent identity: 84.21; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL36 family. (37 aa) |
| | rpsM | Ribosomal protein S13 (rpS13); Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (122 aa) |
| | rpsK | Ribosomal protein S11 (rpS11); Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa) |
| | rpsD | Ribosomal protein S4 (rpS4); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha chain (rpoA); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (328 aa) |
| | rplQ | Ribosomal protein L17 (rplQ); Similar to GB:J01685 SP:P02416 GB:X00766 PID:147716 PID:42800 percent identity: 89.76; identified by sequence similarity; putative. (128 aa) |
| | frr | Ribosome releasing factor (rrf); Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | alaS | alanyl-tRNA synthetase (alaS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (874 aa) |
| | rlmB | Conserved hypothetical protein; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. (246 aa) |
| | rnr | Virulence-associated protein (vacB); 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (782 aa) |
| | ndk | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | obg | GTP-binding protein (yhbZ); An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (390 aa) |
| | HI_0878 | Conserved hypothetical protein; Similar to SP:P28636 PID:216638 PID:606122 GB:U00096 PID:1789575 percent identity: 49.34; identified by sequence similarity; putative. (306 aa) |
| | rpmA | Ribosomal protein L27 (rpL27); Similar to GB:D13267 SP:P02427 PID:216637 PID:606123 GB:U00096 percent identity: 87.06; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL27 family. (85 aa) |
| | rplU | Ribosomal protein L21 (rpL21); This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa) |
| | rhlB | ATP-dependent RNA helicase (rhlB); DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (418 aa) |
| | secA | Preprotein translocase SecA subunit (secA); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (901 aa) |
| | rpsB | Ribosomal protein S2 (rpS2); Similar to GB:D26562 SP:P02351 GB:V00343 PID:42842 PID:473824 percent identity: 82.16; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uS2 family. (251 aa) |
| | tsf | Elongation factor Ts (tsf); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity); Belongs to the EF-Ts family. (283 aa) |
| | leuS | leucyl-tRNA synthetase (leuS); Similar to SP:P07813 GB:X06331 PID:41916 GB:U00096 PID:1651269 percent identity: 72.64; identified by sequence similarity; putative; Belongs to the class-I aminoacyl-tRNA synthetase family. (861 aa) |
| | rpmG | Ribosomal protein L33 (rpL33); Similar to GB:J01677 SP:P02436 PID:147709 PID:290486 GB:U00096 percent identity: 81.48; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL33 family. (56 aa) |
| | rpmB | Ribosomal protein L28 (rpL28); Similar to GB:J01677 SP:P02428 PID:147708 PID:290487 GB:U00096 percent identity: 85.71; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL28 family. (78 aa) |
| | rpsT | Ribosomal protein S20 (rpS20); Binds directly to 16S ribosomal RNA. (89 aa) |
| | smpB | Small protein B (smpB); Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches [...] (161 aa) |
| | rpmH | Ribosomal protein L34 (rpL34); Similar to GB:L10328 SP:P02437 GB:J01602 GB:M11056 PID:145759 percent identity: 86.36; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL34 family. (44 aa) |
| | rnpA | Ribonuclease P (rnpA); RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (119 aa) |
| | HI_1000 | Hemolysin, putative; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. (86 aa) |
| | yidC | Inner membrane protein, 60 kDa (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (541 aa) |
| | mnmE | Thiophene and furan oxidation protein (thdF); Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (461 aa) |
| | hrpA | ATP-dependent helicase (hrpa); Similar to SP:P43329 PID:806328 GB:U00096 PID:1742299 PID:1742304 percent identity: 70.29; identified by sequence similarity; putative. (1304 aa) |
| | xylR | Xylose operon regluatory protein (xylR); Regulatory protein for the xylBAFGHR operon. (387 aa) |
| | engB | Conserved hypothetical GTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (205 aa) |
| | HI_1146 | Conserved hypothetical protein; Displays ATPase and GTPase activities. (289 aa) |
| | prmB | Adenine specific methylase, putative; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. (314 aa) |
| | lysS | lysyl-tRNA synthetase (lysU); Similar to GB:U14003 GB:J03795 SP:P13030 SP:P14825 GB:M30630 percent identity: 70.38; identified by sequence similarity; putative; Belongs to the class-II aminoacyl-tRNA synthetase family. (502 aa) |
| | rpsA | Ribosomal protein S1 (rpS1); Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity). (549 aa) |
| | HI_1225 | Conserved hypothetical protein; Similar to GB:J02768 SP:P08245 PID:147476 GB:U00096 PID:1787538 percent identity: 77.14; identified by sequence similarity; putative; Belongs to the SUI1 family. (106 aa) |
| | metG | methionyl-tRNA synthetase (metG); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (682 aa) |
| | rimP | Conserved hypothetical protein; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. (141 aa) |
| | nusA | N utilization substance protein A (nusA); Participates in both transcription termination and antitermination. (495 aa) |
| | infB | Translation initiation factor 2 (infB); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (829 aa) |
| | rbfA | Ribosome binding factor A (rbfA); One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (128 aa) |
| | truB | tRNA pseudouridine 55 synthase (truB); Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (312 aa) |
| | uup | ABC transporter, ATP-binding protein; Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity; Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily. (647 aa) |
| | asnS | asparaginyl-tRNA synthetase (asnS); Similar to GB:M33145 SP:P17242 GB:X68192 PID:147935 PID:41000 percent identity: 80.65; identified by sequence similarity; putative. (477 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit (pheS); Similar to GB:V00291 SP:P08312 PID:146345 PID:43070 GB:U00096 percent identity: 75.00; identified by sequence similarity; putative; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (329 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit (pheT); Similar to GB:K02844 SP:P07395 PID:146346 PID:43071 GB:U00096 percent identity: 65.28; identified by sequence similarity; putative; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (795 aa) |
| | infC | Translation initiation factor 3 (infC); IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (135 aa) |
| | rpmI | Ribosomal protein L35 (rpL35); Similar to SP:P07085 GB:U00096 PID:1742796 PID:1742809 PID:1788010 percent identity: 78.46; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL35 family. (89 aa) |
| | rplT | Ribosomal protein L20 (rpL20); Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity). (117 aa) |
| | rpsO1 | Ribosomal protein S15 (rpS15); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa) |
| | greA | Transcription elongation factor (greA); Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity). (158 aa) |
| | rlmE | Cell division protein (ftsJ); Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (209 aa) |
| | rng | Cytoplasmic axial filament protein (cafA); Involved in the processing of the 5'-end of 16S rRNA. Could be involved in chromosome segregation and cell division. It may be one of the components of the cytoplasmic axial filaments bundles or merely regulate the formation of this structure (By similarity). (491 aa) |
| | glnS | glutaminyl-tRNA synthetase (glnS); Similar to GB:V01575 SP:P00962 GB:J01617 GB:M10187 PID:146168 percent identity: 76.28; identified by sequence similarity; putative. (557 aa) |
| | thrS | threonyl-tRNA synthetase (thrS); Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (643 aa) |
| | HI_1400 | Conserved hypothetical protein; Efficiently catalyzes the hydrolysis of the 3'-phosphate from 3',5'-bis-phosphonucleotides as well as the successive hydrolysis of 5'-phosphomononucleotides from the 5'-end of short pieces of RNA and DNA, with no specificity toward the identity of the nucleotide base. Is more efficient at hydrolyzing RNA oligonucleotides than DNA oligonucleotides. This enzyme can also hydrolyze annealed DNA duplexes, albeit at a catalytic efficiency lower than that of the corresponding single-stranded oligonucleotides. (274 aa) |
| | sspB | Stringent starvation protein B (sspB); Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans- translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth (By similarity). (150 aa) |
| | sspA | Stringent starvation protein A (sspA); Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme. (212 aa) |
| | rpsI | Ribosomal protein S9 (rpS9); Similar to GB:S75161 SP:P31782 PID:241867 percent identity: 94.62; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uS9 family. (130 aa) |
| | rplM | Ribosomal protein L13 (rpL13); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa) |
| | HI_1468 | Ribosomal protein S15 (rpS15); Similar to GB:J02638 SP:P02371 GB:M14425 GB:X00761 GB:X01073 percent identity: 80.90; identified by sequence similarity; putative. (89 aa) |
| | argS | arginyl-tRNA synthetase (argS); Similar to SP:P11875 GB:X15320 PID:581040 GB:U00096 PID:1736522 percent identity: 71.40; identified by sequence similarity; putative. (577 aa) |
| | tyrS | Tyrosyl tRNA synthetase (tyrS); Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (401 aa) |
| | rplY | Ribosomal protein L25 (rpL25); This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. (95 aa) |
| | orn | Conserved hypothetical protein; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family. (182 aa) |
| | map | Methionine aminopeptidase (map); Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (268 aa) |
| | rnb | Exoribonuclease II (rnb); Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity). (659 aa) |
| | prfC | Peptide chain release factor 3 (prfC); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (527 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega chain (rpoZ); Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). (88 aa) |
