STRINGSTRING
mnmA mnmA glnS glnS metG metG queC queC ribF ribF leuS leuS uspA uspA nadR nadR coaD coaD argG argG HI_1701 HI_1701 citC citC tyrS tyrS argS argS hldE hldE valS valS trpS trpS tilS tilS cysS cysS gltX gltX guaA guaA ttcA ttcA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mnmAConserved hypothetical protein; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (418 aa)
glnSglutaminyl-tRNA synthetase (glnS); Similar to GB:V01575 SP:P00962 GB:J01617 GB:M10187 PID:146168 percent identity: 76.28; identified by sequence similarity; putative. (557 aa)
metGmethionyl-tRNA synthetase (metG); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (682 aa)
queCConserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (196 aa)
ribFRiboflavin kinase / FMN adenylyltransferase (ribF); Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD. (312 aa)
leuSleucyl-tRNA synthetase (leuS); Similar to SP:P07813 GB:X06331 PID:41916 GB:U00096 PID:1651269 percent identity: 72.64; identified by sequence similarity; putative; Belongs to the class-I aminoacyl-tRNA synthetase family. (861 aa)
uspAUniversal stress protein A (uspA); Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. (141 aa)
nadRTranscriptional regulator (nadR); This enzyme has two activities: nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the AMP moiety of ATP to nicotinamide ribonucleotide to form NAD(+); In the C-terminal section; belongs to the bacterial RNK family. (421 aa)
coaDLipopolysaccharide core biosynthesis protein (kdtB); Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (156 aa)
argGArgininosuccinate synthetase (argG); Similar to GB:M35236 SP:P22767 PID:145342 PID:606111 GB:U00096 percent identity: 79.04; identified by sequence similarity; putative; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (444 aa)
HI_1701Conserved hypothetical protein; Similar to PID:1652989 percent identity: 33.19; identified by sequence similarity; putative. (247 aa)
citCCitrate lyase ligase (citC); Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (335 aa)
tyrSTyrosyl tRNA synthetase (tyrS); Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (401 aa)
argSarginyl-tRNA synthetase (argS); Similar to SP:P11875 GB:X15320 PID:581040 GB:U00096 PID:1736522 percent identity: 71.40; identified by sequence similarity; putative. (577 aa)
hldEADP-heptose synthase (rfaE); Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (476 aa)
valSvalyl-tRNA synthetase (valS); Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (954 aa)
trpStryptophanyl-tRNA synthetase (trpS); Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (334 aa)
tilSCell cycle protein (mesJ); Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (430 aa)
cysScysteinyl-tRNA synthetase (cysS); Similar to GB:M59381 SP:P21888 GB:X56234 GB:X59293 PID:145692 percent identity: 75.65; identified by sequence similarity; putative; Belongs to the class-I aminoacyl-tRNA synthetase family. (459 aa)
gltXglutamyl-tRNA synthetase (gltX); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (480 aa)
guaAGMP synthase (guaA); Catalyzes the synthesis of GMP from XMP. (523 aa)
ttcAConserved hypothetical protein; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (313 aa)
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.