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dapF dapF yclM yclM lysA lysA dapH dapH dapL dapL dapA dapA dapB dapB asd asd proC proC patA patA LSA_03490 LSA_03490 gpmA2 gpmA2 prs1 prs1 glnA glnA gpmA1 gpmA1 rpiA rpiA gap gap pgk pgk tpiA tpiA eno eno LSA_05560 LSA_05560 rpe rpe pyk pyk LSA_08440 LSA_08440 metK metK patA-2 patA-2 glyA glyA prs1-2 prs1-2 mtnN mtnN argG argG LSA_10690 LSA_10690 LSA_10700 LSA_10700
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (324 aa)
yclMPutative aspartokinase; Belongs to the aspartokinase family. (456 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (431 aa)
dapH2,3,4,5-tetrahydropyridine-2, 6-dicarboxylateN-ace tyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (235 aa)
dapLPutative N-acetyldiaminopimelate deacetylase; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (397 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (258 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (359 aa)
proCHypothetical protein; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa)
patAPutative aminotransferase A. (335 aa)
LSA_03490Hypothetical protein. (259 aa)
gpmA22,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (232 aa)
prs1Ribose-phosphate pyrophosphokinase 1; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (334 aa)
glnAGlutamine synthetase. (448 aa)
gpmA12,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (233 aa)
rpiARibose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (228 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (388 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (439 aa)
LSA_05560Hypothetical protein. (146 aa)
rpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (229 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (586 aa)
LSA_08440Hypothetical protein. (383 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (396 aa)
patA-2Putative aminotransferase A. (398 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa)
prs1-2Ribose-phosphate pyrophosphokinase 1. (316 aa)
mtnN5'-methylthioadenosine/S- adenosylhomocysteinenucl eosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (243 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (403 aa)
LSA_10690UPF0735 ACT domain-containing protein; Belongs to the UPF0735 family. (144 aa)
LSA_10700Hypothetical protein. (407 aa)
Your Current Organism:
Lactobacillus sanfranciscensis
NCBI taxonomy Id: 714313
Other names: L. sanfranciscensis TMW 1.1304, Lactobacillus sanfranciscensis TMW 1.1304
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