(35 nodes) Melanization defense response network (Anopheles gambiae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Q7PYC4_ANOGA	Mitogen-activated protein kinase kinase 7. (1165 aa)
	SRPN2	Serine protease inhibitor (serpin) 2; Belongs to the serpin family. (409 aa)
	SRPN1	Serine protease inhibitor (serpin) 1; Belongs to the serpin family. (421 aa)
	Q7QG32_ANOGA	Mitogen-activated protein kinase. (375 aa)
	Q7QFI4_ANOGA	AGAP000502-PA. (1026 aa)
	PPO1	Prophenoloxidase 1. (683 aa)
	PPO2	Prophenoloxidase 2. (688 aa)
	Q7Q5K7_ANOGA	AGAP006382-PA. (1069 aa)
	Q7Q5F0_ANOGA	Rho-related BTB domain-containing protein 1/2. (753 aa)
	Q7Q4Q5_ANOGA	AGAP008534-PA. (195 aa)
	Q7Q334_ANOGA	AGAP011463-PA. (417 aa)
	CASPL2	Long caspase (CASPL2); Belongs to the peptidase C14A family. (430 aa)
	Q7Q1T1_ANOGA	AGAP009643-PA. (1097 aa)
	Q7Q0S0_ANOGA	AGAP010192-PA; Belongs to the DOCK family. (2077 aa)
	Q7PZM8_ANOGA	AGAP011988-PA. (80 aa)
	Q7PS74_ANOGA	AGAP003789-PA; Belongs to the band 7/mec-2 family. Flotillin subfamily. (426 aa)
	Q7PRV9_ANOGA	AGAP000489-PA. (1021 aa)
	Q7PQM8_ANOGA	AGAP004194-PA. (1233 aa)
	Q7PPF9_ANOGA	Laminin subunit alpha. (3704 aa)
	Q7PNL6_ANOGA	AGAP005445-PA. (192 aa)
	Q7PN91_ANOGA	AGAP008533-PA. (164 aa)
	Q7PME7_ANOGA	Integrin beta; Belongs to the integrin beta chain family. (803 aa)
	Q7PLZ7_ANOGA	AGAP010292-PA. (762 aa)
	Q7PCP8_ANOGA	AGAP012547-PA; Belongs to the band 7/mec-2 family. Flotillin subfamily. (238 aa)
	Q5TXC6_ANOGA	AGAP009426-PA; Belongs to the ephrin family. (241 aa)
	Q5TUJ6_ANOGA	AGAP010737-PA. (719 aa)
	Q5TPC4_ANOGA	AGAP009628-PA. (324 aa)
	Q380U3_ANOGA	Ras-related C3 botulinum toxin substrate 1. (195 aa)
	Cdc42	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity); Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. (191 aa)
	F5HM87_ANOGA	Dynein heavy chain 1, cytosolic. (4670 aa)
	F5HKZ0_ANOGA	Ras-related C3 botulinum toxin substrate 1 precursor. (194 aa)
	F5HJW6_ANOGA	Neuronal cell adhesion molecule. (1271 aa)
	A7UU91_ANOGA	AGAP006381-PA. (751 aa)
	A7UT88_ANOGA	Ras homolog gene family, member A. (207 aa)
	A7URC8_ANOGA	AGAP007452-PA. (2737 aa)

Your Current Organism:

Anopheles gambiae

NCBI taxonomy Id: 7165
Other names: A. gambiae, African malaria mosquito, Anopheles gambiae S, Anopheles gambiae sensu stricto

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A7URC8_ANOGA	A7UT88_ANOGA	A7URC8	A7UT88	AGAP007452-PA.	Ras homolog gene family, member A.	0.705
A7UT88_ANOGA	A7URC8_ANOGA	A7UT88	A7URC8	Ras homolog gene family, member A.	AGAP007452-PA.	0.705
A7UT88_ANOGA	A7UU91_ANOGA	A7UT88	A7UU91	Ras homolog gene family, member A.	AGAP006381-PA.	0.607
A7UT88_ANOGA	Cdc42	A7UT88	Q17031	Ras homolog gene family, member A.	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity); Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.	0.616
A7UT88_ANOGA	F5HKZ0_ANOGA	A7UT88	F5HKZ0	Ras homolog gene family, member A.	Ras-related C3 botulinum toxin substrate 1 precursor.	0.621
A7UT88_ANOGA	Q380U3_ANOGA	A7UT88	Q380U3	Ras homolog gene family, member A.	Ras-related C3 botulinum toxin substrate 1.	0.617
A7UT88_ANOGA	Q7PLZ7_ANOGA	A7UT88	Q7PLZ7	Ras homolog gene family, member A.	AGAP010292-PA.	0.848
A7UT88_ANOGA	Q7PNL6_ANOGA	A7UT88	Q7PNL6	Ras homolog gene family, member A.	AGAP005445-PA.	0.617
A7UT88_ANOGA	Q7PZM8_ANOGA	A7UT88	Q7PZM8	Ras homolog gene family, member A.	AGAP011988-PA.	0.673
A7UT88_ANOGA	Q7Q0S0_ANOGA	A7UT88	Q7Q0S0	Ras homolog gene family, member A.	AGAP010192-PA; Belongs to the DOCK family.	0.519
A7UT88_ANOGA	Q7Q1T1_ANOGA	A7UT88	Q7Q1T1	Ras homolog gene family, member A.	AGAP009643-PA.	0.939
A7UT88_ANOGA	Q7Q5K7_ANOGA	A7UT88	Q7Q5K7	Ras homolog gene family, member A.	AGAP006382-PA.	0.607
A7UT88_ANOGA	Q7QG32_ANOGA	A7UT88	Q7QG32	Ras homolog gene family, member A.	Mitogen-activated protein kinase.	0.462
A7UU91_ANOGA	A7UT88_ANOGA	A7UU91	A7UT88	AGAP006381-PA.	Ras homolog gene family, member A.	0.607
A7UU91_ANOGA	Cdc42	A7UU91	Q17031	AGAP006381-PA.	Cdc42 homolog; Regulates mbt kinase activity and is also required to recruit mbt to adherens junctions. Together with mbt, regulates photoreceptor cell morphogenesis (By similarity); Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.	0.605
A7UU91_ANOGA	F5HKZ0_ANOGA	A7UU91	F5HKZ0	AGAP006381-PA.	Ras-related C3 botulinum toxin substrate 1 precursor.	0.605
A7UU91_ANOGA	Q380U3_ANOGA	A7UU91	Q380U3	AGAP006381-PA.	Ras-related C3 botulinum toxin substrate 1.	0.605
A7UU91_ANOGA	Q5TPC4_ANOGA	A7UU91	Q5TPC4	AGAP006381-PA.	AGAP009628-PA.	0.512
A7UU91_ANOGA	Q7PNL6_ANOGA	A7UU91	Q7PNL6	AGAP006381-PA.	AGAP005445-PA.	0.605
A7UU91_ANOGA	Q7Q5F0_ANOGA	A7UU91	Q7Q5F0	AGAP006381-PA.	Rho-related BTB domain-containing protein 1/2.	0.457