(14 nodes) U2-type prespliceosome network (Anopheles gambiae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	Q5TUG6_ANOGA	AGAP010349-PA. (455 aa)
	Q5TW61_ANOGA	AGAP011328-PA. (714 aa)
	Q5TWF8_ANOGA	U1 small nuclear ribonucleoprotein 70K. (434 aa)
	Q7PJ85_ANOGA	AGAP008314-PA. (297 aa)
	Q7PNE5_ANOGA	AGAP008263-PA. (863 aa)
	Q7PXB0_ANOGA	AGAP001314-PA. (257 aa)
	AGAP001584	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (152 aa)
	Q7Q400_ANOGA	U6 snRNA-associated Sm-like protein LSm7. (126 aa)
	Q7Q740_ANOGA	Small nuclear ribonucleoprotein-associated protein. (202 aa)
	Q7QCM2_ANOGA	Small nuclear ribonucleoprotein G. (76 aa)
	Q7QD20_ANOGA	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (446 aa)
	Q7QDW3_ANOGA	U1 snRNP splicing complex subunit (Luc7). (330 aa)
	Q7QEW2_ANOGA	Splicing factor 3B subunit 1. (1320 aa)
	Q7QK13_ANOGA	Splicing factor 3a. (256 aa)

Your Current Organism:

Anopheles gambiae

NCBI taxonomy Id: 7165
Other names: A. gambiae, African malaria mosquito, Anopheles gambiae S, Anopheles gambiae sensu stricto

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGAP001584	Q5TW61_ANOGA	Q7PXU6	Q5TW61	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	AGAP011328-PA.	0.814
AGAP001584	Q5TWF8_ANOGA	Q7PXU6	Q5TWF8	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	U1 small nuclear ribonucleoprotein 70K.	0.985
AGAP001584	Q7PJ85_ANOGA	Q7PXU6	Q7PJ85	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	AGAP008314-PA.	0.985
AGAP001584	Q7PNE5_ANOGA	Q7PXU6	Q7PNE5	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	AGAP008263-PA.	0.938
AGAP001584	Q7Q400_ANOGA	Q7PXU6	Q7Q400	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	U6 snRNA-associated Sm-like protein LSm7.	0.875
AGAP001584	Q7Q740_ANOGA	Q7PXU6	Q7Q740	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	Small nuclear ribonucleoprotein-associated protein.	0.995
AGAP001584	Q7QCM2_ANOGA	Q7PXU6	Q7QCM2	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	Small nuclear ribonucleoprotein G.	0.996
AGAP001584	Q7QD20_ANOGA	Q7PXU6	Q7QD20	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.865
AGAP001584	Q7QDW3_ANOGA	Q7PXU6	Q7QDW3	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	U1 snRNP splicing complex subunit (Luc7).	0.877
AGAP001584	Q7QEW2_ANOGA	Q7PXU6	Q7QEW2	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	Splicing factor 3B subunit 1.	0.986
AGAP001584	Q7QK13_ANOGA	Q7PXU6	Q7QK13	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	Splicing factor 3a.	0.961
Q5TW61_ANOGA	AGAP001584	Q5TW61	Q7PXU6	AGAP011328-PA.	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.	0.814
Q5TW61_ANOGA	Q5TWF8_ANOGA	Q5TW61	Q5TWF8	AGAP011328-PA.	U1 small nuclear ribonucleoprotein 70K.	0.745
Q5TW61_ANOGA	Q7PJ85_ANOGA	Q5TW61	Q7PJ85	AGAP011328-PA.	AGAP008314-PA.	0.760
Q5TW61_ANOGA	Q7PNE5_ANOGA	Q5TW61	Q7PNE5	AGAP011328-PA.	AGAP008263-PA.	0.853
Q5TW61_ANOGA	Q7Q400_ANOGA	Q5TW61	Q7Q400	AGAP011328-PA.	U6 snRNA-associated Sm-like protein LSm7.	0.953
Q5TW61_ANOGA	Q7Q740_ANOGA	Q5TW61	Q7Q740	AGAP011328-PA.	Small nuclear ribonucleoprotein-associated protein.	0.993
Q5TW61_ANOGA	Q7QCM2_ANOGA	Q5TW61	Q7QCM2	AGAP011328-PA.	Small nuclear ribonucleoprotein G.	0.985
Q5TW61_ANOGA	Q7QD20_ANOGA	Q5TW61	Q7QD20	AGAP011328-PA.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.832
Q5TW61_ANOGA	Q7QDW3_ANOGA	Q5TW61	Q7QDW3	AGAP011328-PA.	U1 snRNP splicing complex subunit (Luc7).	0.686