STRINGSTRING
CTU2_ANOGA CTU2_ANOGA A7UVL3_ANOGA A7UVL3_ANOGA A8B1J8_ANOGA A8B1J8_ANOGA F5HLZ2_ANOGA F5HLZ2_ANOGA RpL5 RpL5 RpS3A RpS3A Act5C Act5C nkd nkd Gnpda1 Gnpda1 Q5TP19_ANOGA Q5TP19_ANOGA Q5TPI0_ANOGA Q5TPI0_ANOGA ASNA_ANOGA ASNA_ANOGA Q5TSL8_ANOGA Q5TSL8_ANOGA Mocs2 Mocs2 Q5TTI6_ANOGA Q5TTI6_ANOGA Q5TTR3_ANOGA Q5TTR3_ANOGA Q5TUI7_ANOGA Q5TUI7_ANOGA Q5TX32_ANOGA Q5TX32_ANOGA Q7PFA8_ANOGA Q7PFA8_ANOGA eIF3-S10 eIF3-S10 Q7PGM0_ANOGA Q7PGM0_ANOGA Q7PGM1_ANOGA Q7PGM1_ANOGA unc-104 unc-104 Q7PJK1_ANOGA Q7PJK1_ANOGA Q7PKL9_ANOGA Q7PKL9_ANOGA Q7PKM9_ANOGA Q7PKM9_ANOGA AGAP001589 AGAP001589 Q7PLX5_ANOGA Q7PLX5_ANOGA Q7PMD7_ANOGA Q7PMD7_ANOGA Q7PMF3_ANOGA Q7PMF3_ANOGA Q7PMK6_ANOGA Q7PMK6_ANOGA lig lig Q7PMU5_ANOGA Q7PMU5_ANOGA eIF3-S8 eIF3-S8 Q7PNH7_ANOGA Q7PNH7_ANOGA Q7PNZ3_ANOGA Q7PNZ3_ANOGA EIF3I_ANOGA EIF3I_ANOGA Q7PPI7_ANOGA Q7PPI7_ANOGA Q7PPL9_ANOGA Q7PPL9_ANOGA Q7PPM9_ANOGA Q7PPM9_ANOGA Q7PPR6_ANOGA Q7PPR6_ANOGA Q7PQ65_ANOGA Q7PQ65_ANOGA Q7PQ97_ANOGA Q7PQ97_ANOGA Q7PR73_ANOGA Q7PR73_ANOGA MTNB_ANOGA MTNB_ANOGA Moe Moe Q7PSH4_ANOGA Q7PSH4_ANOGA Q7PSI4_ANOGA Q7PSI4_ANOGA Hsp83 Hsp83 Q7PT72_ANOGA Q7PT72_ANOGA Q7PTC8_ANOGA Q7PTC8_ANOGA Q7PTD5_ANOGA Q7PTD5_ANOGA Q7PUB7_ANOGA Q7PUB7_ANOGA Q7PUE2_ANOGA Q7PUE2_ANOGA Q7PUF2_ANOGA Q7PUF2_ANOGA Q7PUU9_ANOGA Q7PUU9_ANOGA NUBP1_ANOGA NUBP1_ANOGA gammaCop gammaCop Q7PVI0_ANOGA Q7PVI0_ANOGA EIF3H_ANOGA EIF3H_ANOGA Arc-p34 Arc-p34 Q7PWI8_ANOGA Q7PWI8_ANOGA Q7PWN2_ANOGA Q7PWN2_ANOGA Q7PWP6_ANOGA Q7PWP6_ANOGA DRE2_ANOGA DRE2_ANOGA hook hook Q7PWU6_ANOGA Q7PWU6_ANOGA Q7PWV4_ANOGA Q7PWV4_ANOGA Q7PX58_ANOGA Q7PX58_ANOGA Q7PXC4_ANOGA Q7PXC4_ANOGA Q7PXF4_ANOGA Q7PXF4_ANOGA Q7PXG9_ANOGA Q7PXG9_ANOGA D1.1 D1.1 Q7PY05_ANOGA Q7PY05_ANOGA Q7PY13_ANOGA Q7PY13_ANOGA MOCS3_ANOGA MOCS3_ANOGA Q7PY59_ANOGA Q7PY59_ANOGA Q7PY77_ANOGA Q7PY77_ANOGA Q7PYH3_ANOGA Q7PYH3_ANOGA Q7PYI0_ANOGA Q7PYI0_ANOGA Cry1 Cry1 DCTN2-p50 DCTN2-p50 PrBP PrBP RSSA_ANOGA RSSA_ANOGA Q7PZD3_ANOGA Q7PZD3_ANOGA K0664_ANOGA K0664_ANOGA king-tubby king-tubby eIF3-S9 eIF3-S9 EIF3M_ANOGA EIF3M_ANOGA Q7Q0N0_ANOGA Q7Q0N0_ANOGA Q7Q0Q4_ANOGA Q7Q0Q4_ANOGA Q7Q0U7_ANOGA Q7Q0U7_ANOGA Q7Q192_ANOGA Q7Q192_ANOGA Q7Q1I2_ANOGA Q7Q1I2_ANOGA Q7Q289_ANOGA Q7Q289_ANOGA Q7Q292_ANOGA Q7Q292_ANOGA Q7Q2B0_ANOGA Q7Q2B0_ANOGA CARM1 CARM1 Q7Q306_ANOGA Q7Q306_ANOGA Q7Q320_ANOGA Q7Q320_ANOGA Q7Q467_ANOGA Q7Q467_ANOGA Q7Q477_ANOGA Q7Q477_ANOGA Q7Q4D3_ANOGA Q7Q4D3_ANOGA AGAP008374 AGAP008374 Q7Q4N4_ANOGA Q7Q4N4_ANOGA Q7Q558_ANOGA Q7Q558_ANOGA EIF3J_ANOGA EIF3J_ANOGA Q7QD16_ANOGA Q7QD16_ANOGA Q7Q5C2_ANOGA Q7Q5C2_ANOGA Q7Q5G8_ANOGA Q7Q5G8_ANOGA Q7Q5L6_ANOGA Q7Q5L6_ANOGA EIF3L_ANOGA EIF3L_ANOGA AGAP006124 AGAP006124 A0A1W5CAE5 A0A1W5CAE5 Pym Pym URM1_ANOGA URM1_ANOGA PAN3 PAN3 Q7Q6T8_ANOGA Q7Q6T8_ANOGA Q7Q6T9_ANOGA Q7Q6T9_ANOGA Q7Q6X6_ANOGA Q7Q6X6_ANOGA Q7Q703_ANOGA Q7Q703_ANOGA QTRD1_ANOGA QTRD1_ANOGA Q7Q797_ANOGA Q7Q797_ANOGA Q7Q7K5_ANOGA Q7Q7K5_ANOGA Q7Q7N8_ANOGA Q7Q7N8_ANOGA Q7Q808_ANOGA Q7Q808_ANOGA Q7Q8F6_ANOGA Q7Q8F6_ANOGA Mad Mad Q7Q8S5_ANOGA Q7Q8S5_ANOGA ENOPH_ANOGA ENOPH_ANOGA KTU_ANOGA KTU_ANOGA CTU1_ANOGA CTU1_ANOGA AGAP005129 AGAP005129 Mocs2-2 Mocs2-2 Q7QAM7_ANOGA Q7QAM7_ANOGA Q7QAU9_ANOGA Q7QAU9_ANOGA Q7QB14_ANOGA Q7QB14_ANOGA spas spas eIF3-S7 eIF3-S7 Q7QCF9_ANOGA Q7QCF9_ANOGA Q7QCH6_ANOGA Q7QCH6_ANOGA Tctp Tctp Q7QCQ5_ANOGA Q7QCQ5_ANOGA eIF3-S5 eIF3-S5 Q7QDE6_ANOGA Q7QDE6_ANOGA Q7QDK6_ANOGA Q7QDK6_ANOGA Q7QDU2_ANOGA Q7QDU2_ANOGA Stat Stat Q7QDY2_ANOGA Q7QDY2_ANOGA spn-E spn-E Q7QE04_ANOGA Q7QE04_ANOGA Q7QE29_ANOGA Q7QE29_ANOGA Q7QEC0_ANOGA Q7QEC0_ANOGA Q7QEG0_ANOGA Q7QEG0_ANOGA STAT2 STAT2 Q7QEX4_ANOGA Q7QEX4_ANOGA KATNB1 KATNB1 Q7QFS6_ANOGA Q7QFS6_ANOGA twf twf Q7QG50_ANOGA Q7QG50_ANOGA EIF3K_ANOGA EIF3K_ANOGA NUBP2_ANOGA NUBP2_ANOGA Q7QGY6_ANOGA Q7QGY6_ANOGA Q7QH99_ANOGA Q7QH99_ANOGA Q7QHT9_ANOGA Q7QHT9_ANOGA arm arm Q7QHZ9_ANOGA Q7QHZ9_ANOGA Q7QII4_ANOGA Q7QII4_ANOGA eIF3-S6 eIF3-S6 Q7QIM5_ANOGA Q7QIM5_ANOGA Q7QJ32_ANOGA Q7QJ32_ANOGA Q7QJB5_ANOGA Q7QJB5_ANOGA Q7QJF6_ANOGA Q7QJF6_ANOGA RpL18 RpL18 eIF3-S4 eIF3-S4 Adk2 Adk2 Q7QK01_ANOGA Q7QK01_ANOGA Q7QK73_ANOGA Q7QK73_ANOGA Q7QLL8_ANOGA Q7QLL8_ANOGA Q8T0Y8_ANOGA Q8T0Y8_ANOGA RpS26 RpS26 RpL8 RpL8
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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CTU2_ANOGACytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. (417 aa)
A7UVL3_ANOGATubulin-specific chaperone A; Belongs to the TBCA family. (114 aa)
A8B1J8_ANOGAActin beta/gamma 1. (376 aa)
F5HLZ2_ANOGAFascin. (511 aa)
RpL560S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (325 aa)
RpS3A40S ribosomal protein S3a; Has an essential role in oogenesis. (269 aa)
Act5CActin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction; Belongs to the actin family. (376 aa)
nkdProtein naked cuticle homolog; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for neuroblast specification (By similarity); Belongs to the NKD family. (886 aa)
Gnpda1Glucosamine-6-phosphate isomerase. (273 aa)
Q5TP19_ANOGAProfilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (126 aa)
Q5TPI0_ANOGACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (606 aa)
ASNA_ANOGAATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...] (337 aa)
Q5TSL8_ANOGADynein light chain roadblock. (97 aa)
Mocs2Molybdopterin synthase sulfur carrier subunit; Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin; Belongs to the MoaD family. MOCS2A subfamily. (91 aa)
Q5TTI6_ANOGATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (442 aa)
Q5TTR3_ANOGATyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (643 aa)
Q5TUI7_ANOGAProteasome subunit beta. (284 aa)
Q5TX32_ANOGAATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (789 aa)
Q7PFA8_ANOGATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (505 aa)
eIF3-S10Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (1124 aa)
Q7PGM0_ANOGAT-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (542 aa)
Q7PGM1_ANOGATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (436 aa)
unc-104Kinesin-like protein unc-104; Required for presynaptic maturation, has a role in axonal transport of dense-core vesicles carrying synaptic vesicle precursors, components required for the morphological transformation of axonal growth cones to mature boutons. (1644 aa)
Q7PJK1_ANOGAUbiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. (682 aa)
Q7PKL9_ANOGABleomycin hydrolase; Belongs to the peptidase C1 family. (455 aa)
Q7PKM9_ANOGAD-aminoacyl-tRNA deacylase. (197 aa)
AGAP001589Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (351 aa)
Q7PLX5_ANOGAGPN-loop GTPase; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. (312 aa)
Q7PMD7_ANOGAProteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (275 aa)
Q7PMF3_ANOGARab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (443 aa)
Q7PMK6_ANOGAElongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1326 aa)
ligProtein lingerer; Acts in the nervous system to mediate the control of copulatory organs during courtship. (1249 aa)
Q7PMU5_ANOGACoatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (952 aa)
eIF3-S8Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (955 aa)
Q7PNH7_ANOGAF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (275 aa)
Q7PNZ3_ANOGA60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (510 aa)
EIF3I_ANOGAEukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (327 aa)
Q7PPI7_ANOGAProteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (259 aa)
Q7PPL9_ANOGACOP9 signalosome complex subunit. (445 aa)
Q7PPM9_ANOGAProteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (242 aa)
Q7PPR6_ANOGATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
Q7PQ65_ANOGA5'-3' exoribonuclease 1. (1705 aa)
Q7PQ97_ANOGADipeptidyl peptidase 3; Belongs to the peptidase M49 family. (722 aa)
Q7PR73_ANOGADynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (261 aa)
MTNB_ANOGAProbable methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). (231 aa)
MoeMoesin/ezrin/radixin homolog 1; Involved in connections of major cytoskeletal structures to the plasma membrane. (581 aa)
Q7PSH4_ANOGASpectrin beta chain; Belongs to the spectrin family. (2301 aa)
Q7PSI4_ANOGATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (447 aa)
Hsp83Heat shock protein 83; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for piRNA biogenesis by facilitating loading of piRNAs into PIW [...] (720 aa)
Q7PT72_ANOGATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
Q7PTC8_ANOGARibosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (293 aa)
Q7PTD5_ANOGAAconitate hydratase 1 / homoaconitase; Belongs to the aconitase/IPM isomerase family. (901 aa)
Q7PUB7_ANOGAActin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
Q7PUE2_ANOGATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
Q7PUF2_ANOGAActin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
Q7PUU9_ANOGAMicrotubule-associated protein. (832 aa)
NUBP1_ANOGACytosolic Fe-S cluster assembly factor NUBP1 homolog; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (325 aa)
gammaCopCoatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). ECO:0000250|UniProtKB:P53620, ECO:0000250|UniProtKB:P53622. (868 aa)
Q7PVI0_ANOGAProteasome subunit beta. (229 aa)
EIF3H_ANOGAEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (334 aa)
Arc-p34Probable actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). (304 aa)
Q7PWI8_ANOGAMevalonate kinase. (412 aa)
Q7PWN2_ANOGAActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (374 aa)
Q7PWP6_ANOGAActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (156 aa)
DRE2_ANOGAAnamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...] (254 aa)
hookProtein hook; Involved in endocytic trafficking. Probably acts as a cytoskeletal linker protein that tethers endosome vesicles to the cytoskeleton; Belongs to the hook family. (690 aa)
Q7PWU6_ANOGAGamma-tubulin complex component. (695 aa)
Q7PWV4_ANOGAProteasome subunit beta. (207 aa)
Q7PX58_ANOGAGamma-tubulin complex component. (1037 aa)
Q7PXC4_ANOGADynein light chain. (89 aa)
Q7PXF4_ANOGAEukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (245 aa)
Q7PXG9_ANOGACoatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (959 aa)
D1.1Actin, cytoplasmic. (376 aa)
Q7PY05_ANOGAU6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (134 aa)
Q7PY13_ANOGAProteasome subunit beta. (205 aa)
MOCS3_ANOGAAdenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (441 aa)
Q7PY59_ANOGAProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (772 aa)
Q7PY77_ANOGAKatanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (573 aa)
Q7PYH3_ANOGASignal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP72 family. (696 aa)
Q7PYI0_ANOGASuppressor of fused homolog. (465 aa)
Cry1Cryptochrome-1; Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry (By similarity); Belongs to the DNA ph [...] (545 aa)
DCTN2-p50Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. (387 aa)
PrBPProbable cGMP 3',5'-cyclic phosphodiesterase subunit delta; Belongs to the PDE6D/unc-119 family. (151 aa)
RSSA_ANOGA40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (285 aa)
Q7PZD3_ANOGAAGAP011849-PA. (398 aa)
K0664_ANOGAClustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria; Belongs to the CLU family. (1463 aa)
king-tubbyProtein king tubby. (447 aa)
eIF3-S9Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (683 aa)
EIF3M_ANOGAEukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (385 aa)
Q7Q0N0_ANOGACoatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1231 aa)
Q7Q0Q4_ANOGAProtein-lysine N-methyltransferase AgaP_AGAP010213; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family. (231 aa)
Q7Q0U7_ANOGAATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1082 aa)
Q7Q192_ANOGALeukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (646 aa)
Q7Q1I2_ANOGAMothers against decapentaplegic homolog. (506 aa)
Q7Q289_ANOGAPutative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (307 aa)
Q7Q292_ANOGAUMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (253 aa)
Q7Q2B0_ANOGAProteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (246 aa)
CARM1Histone-arginine methyltransferase CARMER; Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in proteins. May methylate histone H3 at 'Arg-17' and activate transcription via chromatin remodeling. (622 aa)
Q7Q306_ANOGAProteasome subunit beta. (279 aa)
Q7Q320_ANOGAProteasome subunit beta; Belongs to the peptidase T1B family. (271 aa)
Q7Q467_ANOGAChaperonin containing TCP1 subunit 5. (540 aa)
Q7Q477_ANOGAProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (388 aa)
Q7Q4D3_ANOGAMethionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (505 aa)
AGAP008374Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (188 aa)
Q7Q4N4_ANOGACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (389 aa)
Q7Q558_ANOGACoatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family. (304 aa)
EIF3J_ANOGAEukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (240 aa)
Q7QD16_ANOGAMothers against decapentaplegic homolog. (784 aa)
Q7Q5C2_ANOGACoatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (177 aa)
Q7Q5G8_ANOGAAGAP006445-PA. (448 aa)
Q7Q5L6_ANOGARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (164 aa)
EIF3L_ANOGAEukaryotic translation initiation factor 3 subunit L; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (539 aa)
AGAP006124tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family. (556 aa)
A0A1W5CAE5Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (278 aa)
PymPartner of Y14 and mago; Regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. (233 aa)
URM1_ANOGAUbiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress spec [...] (109 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (737 aa)
Q7Q6T8_ANOGAProtein-lysine N-methyltransferase AgaP_AGAP005673; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family. (220 aa)
Q7Q6T9_ANOGAStaphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (919 aa)
Q7Q6X6_ANOGA1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (183 aa)
Q7Q703_ANOGAGamma-tubulin complex component. (853 aa)
QTRD1_ANOGAQueuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (432 aa)
Q7Q797_ANOGAProteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (249 aa)
Q7Q7K5_ANOGAAGAP011515-PA. (352 aa)
Q7Q7N8_ANOGASignal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
Q7Q808_ANOGATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (441 aa)
Q7Q8F6_ANOGASerine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (360 aa)
MadMothers against decapentaplegic homolog. (474 aa)
Q7Q8S5_ANOGAChaperonin containing TCP1 subunit 8. (546 aa)
ENOPH_ANOGAEnolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (295 aa)
KTU_ANOGAProtein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. Belongs to the PIH1 family. Kintoun subfamily. (862 aa)
CTU1_ANOGACytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. (342 aa)
AGAP005129S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (278 aa)
Mocs2-2Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily. (154 aa)
Q7QAM7_ANOGAQueuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (415 aa)
Q7QAU9_ANOGAO-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. (482 aa)
Q7QB14_ANOGAChaperonin containing TCP1 subunit 1. (557 aa)
spasSpastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the microtubule organizing center following nucleation; Belongs to the AAA ATPase family. Spastin subfamily. (827 aa)
eIF3-S7Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs. (584 aa)
Q7QCF9_ANOGARibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (328 aa)
Q7QCH6_ANOGAS-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (283 aa)
TctpTranslationally-controlled tumor protein homolog; Involved in calcium binding and microtubule stabilization. Belongs to the TCTP family. (171 aa)
Q7QCQ5_ANOGAT-complex protein 1 subunit gamma. (547 aa)
eIF3-S5Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (287 aa)
Q7QDE6_ANOGAChaperonin containing TCP1 subunit 6. (531 aa)
Q7QDK6_ANOGAAdenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (466 aa)
Q7QDU2_ANOGARab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (588 aa)
StatSignal transducer and transcription activator; Signal transduction and activation of transcription. Plays an important role in the segmental pattern formation in the early embryo by activating specific stripes of pair rule gene expression (By similarity). The STAT pathway directly participates in immune responses in insects; Belongs to the transcription factor STAT family. (722 aa)
Q7QDY2_ANOGAAlpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (126 aa)
spn-EProbable ATP-dependent RNA helicase spindle-E; Probable ATP-binding RNA helicase which plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). (1463 aa)
Q7QE04_ANOGACoatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (537 aa)
Q7QE29_ANOGA5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (302 aa)
Q7QEC0_ANOGADynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (518 aa)
Q7QEG0_ANOGAObg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (398 aa)
STAT2Signal transducer and activator of transcription. (726 aa)
Q7QEX4_ANOGACytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1287 aa)
KATNB1Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (934 aa)
Q7QFS6_ANOGAGamma-tubulin complex component. (854 aa)
twfTwinfilin; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin (By similarity). (343 aa)
Q7QG50_ANOGAT-complex protein 1 subunit delta. (533 aa)
EIF3K_ANOGAEukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (221 aa)
NUBP2_ANOGACytosolic Fe-S cluster assembly factor NUBP2 homolog; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (259 aa)
Q7QGY6_ANOGAGamma-tubulin complex component. (1073 aa)
Q7QH99_ANOGAPolyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (634 aa)
Q7QHT9_ANOGAPhosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (254 aa)
armArmadillo segment polarity protein; May associate with CadN and participate in the transmission of developmental information. Can associate with alpha-catenin. Accumulates through wg signaling; arm function in wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis (By similarity). Belongs to the beta-catenin family. (850 aa)
Q7QHZ9_ANOGAActin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (395 aa)
Q7QII4_ANOGADynein light chain. (105 aa)
eIF3-S6Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (433 aa)
Q7QIM5_ANOGAProbable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (346 aa)
Q7QJ32_ANOGACleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (231 aa)
Q7QJB5_ANOGADIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (1209 aa)
Q7QJF6_ANOGASignal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. (77 aa)
RpL1860S ribosomal protein L18. (189 aa)
eIF3-S4Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (271 aa)
Adk2Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (240 aa)
Q7QK01_ANOGANADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family. (586 aa)
Q7QK73_ANOGASignal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP68 family. (625 aa)
Q7QLL8_ANOGAProteasome subunit beta; Belongs to the peptidase T1B family. (271 aa)
Q8T0Y8_ANOGAProteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (234 aa)
RpS2640S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
RpL860S ribosomal protein L8. (261 aa)
Your Current Organism:
Anopheles gambiae
NCBI taxonomy Id: 7165
Other names: A. gambiae, African malaria mosquito, Anopheles gambiae S, Anopheles gambiae sensu stricto
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