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gmk gmk ndk ndk der der dut dut AEG31178.1 AEG31178.1 AEG31203.1 AEG31203.1 ppnP ppnP dcd dcd pyrG pyrG AEG31485.1 AEG31485.1 surE surE pcm pcm AEG31488.1 AEG31488.1 cmk cmk tmk tmk AEG31960.1 AEG31960.1 AEG31961.1 AEG31961.1 AEG32232.1 AEG32232.1 apt apt
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (134 aa)
derGTP-binding protein engA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (475 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (153 aa)
AEG31178.1TIGRFAM: Pseudouridine synthase, RsuA and RluB/E/F; PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; RNA-binding S4; KEGG: bbe:BBR47_08490 pseudouridine synthase; SMART: RNA-binding S4; Belongs to the pseudouridine synthase RsuA family. (230 aa)
AEG31203.1KEGG: tcx:Tcr_1757 HAD family hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase-like hydrolase. (227 aa)
ppnPUPF0345 protein yaiE; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (103 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (204 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (543 aa)
AEG31485.1KEGG: tcx:Tcr_1258 Smr protein/MutS2-like; PFAM: Smr protein/MutS2 C-terminal; SMART: Smr protein/MutS2 C-terminal. (189 aa)
surEMultifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (248 aa)
pcmProtein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (237 aa)
AEG31488.1PFAM: SNARE associated Golgi protein; KEGG: tcx:Tcr_1255 hypothetical protein. (192 aa)
cmkPFAM: Cytidylate kinase region; TIGRFAM: Cytidylate kinase; HAMAP: Cytidylate kinase; KEGG: tcx:Tcr_1197 cytidylate kinase. (219 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa)
AEG31960.1Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (758 aa)
AEG31961.1PFAM: Ribonucleotide reductase; KEGG: tcx:Tcr_1763 ribonucleotide-diphosphate reductase subunit beta. (377 aa)
AEG32232.1PFAM: Conserved hypothetical protein CHP00730; KEGG: tcx:Tcr_1882 hypothetical protein. (459 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (175 aa)
Your Current Organism:
Thiomicrospira cyclica
NCBI taxonomy Id: 717773
Other names: T. cyclica ALM1, Thioalkalimicrobium cyclicum ALM1, Thiomicrospira cyclica ALM1
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