STRINGSTRING
CCB66608.1 CCB66608.1 dapE dapE dapD dapD lysA lysA CCB63401.1 CCB63401.1 CCB63479.1 CCB63479.1 CCB63538.1 CCB63538.1 aroA aroA folC folC gltD gltD gltB gltB CCB64253.1 CCB64253.1 CCB64338.1 CCB64338.1 CCB64368.1 CCB64368.1 dapA dapA CCB64676.1 CCB64676.1 folK folK CCB65157.1 CCB65157.1 CCB65413.1 CCB65413.1 CCB65490.1 CCB65490.1 aroC aroC nadA nadA aroQ aroQ CCB66596.1 CCB66596.1 CCB66660.1 CCB66660.1 CCB66753.1 CCB66753.1 fumC fumC CCB67479.1 CCB67479.1 mgsB mgsB mgsC mgsC CCB67601.1 CCB67601.1 aroK aroK aroE aroE dapF dapF asdB asdB dapB dapB tme tme ask ask
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCB66608.1Beta-lactamase domain protein. (374 aa)
dapEN-succinyl-diaminopimelate deacylase (dapE); Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (390 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the transferase hexapeptide repeat family. (280 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (426 aa)
CCB63401.1Putative dihydrodipicolinate synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the DapA family. (307 aa)
CCB63479.1FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (447 aa)
CCB63538.1L-carnitine dehydratase/bile acid-inducible protein F; Belongs to the CoA-transferase III family. (398 aa)
aroA3-enolpyruvylshikimate-5-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (446 aa)
folCBifunctional folylpolyglutamate synthase and dihydrofolate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (467 aa)
gltDGlutamate synthase, small subunit, nucleotide-binding, 4Fe-4S protein; Function of strongly homologous gene; enzyme. (479 aa)
gltBGlutamate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1575 aa)
CCB64253.1Dihydropteroate synthase. (385 aa)
CCB64338.1Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1060 aa)
CCB64368.1Chorismate mutase, type II. (116 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa)
CCB64676.1CDGSH iron-sulfur domain-containing protein 3, mitochondrial (fragment). (80 aa)
folK2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (174 aa)
CCB65157.1Homologs of previously reported genes of unknown function. (115 aa)
CCB65413.1Phosphopantetheine-binding protein. (89 aa)
CCB65490.1Putative imidazolonepropionase HutI; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (436 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (362 aa)
nadAPutative quinolinate synthetase A (nadA-like); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (352 aa)
aroQ3-dehydroquinate dehydratase (3-dehydroquinase) (Type II DHQase); Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa)
CCB66596.1Putative dihydrodipicolinate synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the DapA family. (307 aa)
CCB66660.1L-carnitine dehydratase/bile acid-inducible protein F; Belongs to the CoA-transferase III family. (397 aa)
CCB66753.1Acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase. (425 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (481 aa)
CCB67479.1Conserved protein (Orf20) involved in biosynthesis of tetrahydromethanopterin; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (469 aa)
mgsBN-methyl glutamate synthase subunit B; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (228 aa)
mgsCN-methylglutamate synthase subunit C; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the glutamate synthase family. (445 aa)
CCB67601.1Putative phosphoenolpyruvate carboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the PEPCase type 1 family. (950 aa)
aroKBifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (588 aa)
aroEPutative shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (276 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (289 aa)
asdBAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (267 aa)
tmeNADP-dependent malic enzyme. (757 aa)
askAspartate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartokinase family. (420 aa)
Your Current Organism:
Hyphomicrobium sp. MC1
NCBI taxonomy Id: 717785
Other names: H. sp. MC1
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