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mxaF mxaF mxaJ mxaJ mxaG mxaG mxaI mxaI CCB63725.1 CCB63725.1 mxaC mxaC CCB63727.1 CCB63727.1 mxaL mxaL mxaD mxaD gck gck CCB64033.1 CCB64033.1 CCB64206.1 CCB64206.1 fdh2A fdh2A fdh2B fdh2B fdsG fdsG CCB64227.1 CCB64227.1 serC serC fae fae CCB64846.1 CCB64846.1 CCB64848.1 CCB64848.1 CCB64852.1 CCB64852.1 fae-2 fae-2 mch mch mtdB mtdB fhcC fhcC ffsA ffsA fhcA fhcA CCB65111.1 CCB65111.1 CCB65118.1 CCB65118.1 CCB65159.1 CCB65159.1 CCB65163.1 CCB65163.1 eno eno fae-3 fae-3 CCB65467.1 CCB65467.1 cmuB cmuB glpX glpX fdh fdh CCB65952.1 CCB65952.1 glyA glyA CCB66138.1 CCB66138.1 fdoG fdoG fdoH fdoH fdoI fdoI CCB66651.1 CCB66651.1 fbiD fbiD CCB66759.1 CCB66759.1 cofE cofE CCB66823.1 CCB66823.1 CCB66824.1 CCB66824.1 sga sga CCB67171.1 CCB67171.1 CCB67172.1 CCB67172.1 CCB67329.1 CCB67329.1 mgdA-2 mgdA-2 CCB67568.1 CCB67568.1 mgdC-2 mgdC-2 CCB67570.1 CCB67570.1 mgsA mgsA mgsB mgsB mgsC mgsC cbbF cbbF CCB67601.1 CCB67601.1 mtkB mtkB mtkA mtkA mcl mcl sga-2 sga-2 mdh mdh gpmA gpmA acs acs
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mxaFMethanol dehydrogenase, alpha subunit precursor; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (631 aa)
mxaJMethanol oxidation protein MxaJ; Function of homologous gene experimentally demonstrated in an other organism. (302 aa)
mxaGCytochrome c-L precursor; Electron acceptor for MDH. Acts in methanol oxidation. (193 aa)
mxaIMethanol dehydrogenase, beta subunit precursor; Catalyzes the oxidation of primary alcohols including methanol. (99 aa)
CCB63725.1Putative MxaA protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (324 aa)
mxaCMxaC protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (334 aa)
CCB63727.1Homologs of previously reported genes of unknown function. (193 aa)
mxaLMxaL protein precursor; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (341 aa)
mxaDMxaD protein precursor; Homologs of previously reported genes of unknown function. (178 aa)
gckGlycerate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (431 aa)
CCB64033.1Putative PQQ-linked dehydrogenase precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (606 aa)
CCB64206.1Homologs of previously reported genes of unknown function. (103 aa)
fdh2ANAD-dependent formate dehydrogenase, molybdenum containing, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (972 aa)
fdh2BNAD-dependent formate dehydrogenase, Molybdenum containing, beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (521 aa)
fdsGNAD-dependent formate dehydrogenase gamma subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (175 aa)
CCB64227.1Putative fructose-bisphosphate aldolase class 1; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (344 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (389 aa)
faeFormaldehyde activating enzyme homolog; Function of strongly homologous gene; putative enzyme. (188 aa)
CCB64846.1Conserved protein (Orf22) involved in biosynthesis of tetrahydromethanopterin; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (244 aa)
CCB64848.1Conserved protein (Orf21) involved in biosynthesis of tetrahydromethanopterin, putative kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (206 aa)
CCB64852.1Putative conserved protein (Orf9) involved in biosynthesis of tetrahydromethanopterin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (337 aa)
fae-2Formaldehyde-activating enzyme; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (170 aa)
mchN(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase (methenyl-H4MPT cyclohydrolase); Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family. (319 aa)
mtdBNAD(P)-dependent methylene tetrahydromethanopterin dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (301 aa)
fhcCFormyltransferase/hydrolase complex Fhc subunit C; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (270 aa)
ffsAFormylmethanofuran--tetrahydromethanopterin formyltransferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family. (301 aa)
fhcAFormyltransferase/hydrolase complex Fhc subunit A; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (554 aa)
CCB65111.1Formylmethanofuran dehydrogenase subunit B. (427 aa)
CCB65118.1Putative PQQ-linked dehydrogenase precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (606 aa)
CCB65159.1Putative Long-chain acyl-CoA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (513 aa)
CCB65163.1Putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the HpcH/HpaI aldolase family. (353 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
fae-3Formaldehyde activating enzyme homolog; Function of strongly homologous gene; putative enzyme. (179 aa)
CCB65467.1Homologs of previously reported genes of unknown function. (150 aa)
cmuBTetrahydromethanopterin S-methyltransferase. (311 aa)
glpXFructose 1,6-bisphosphatase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (333 aa)
fdhFormate dehydrogenase (NAD-dependent formate dehydrogenase) (FDH); Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (400 aa)
CCB65952.1Putative flavin-containing monooxygenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (454 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (434 aa)
CCB66138.1Exported protein of unknown function; No homology to any previously reported sequences. (197 aa)
fdoGFormate dehydrogenase-O major subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (821 aa)
fdoHFormate dehydrogenase-O iron-sulfur subunit. (315 aa)
fdoIFormate dehydrogenase, cytochrome b556(fdo) subunit. (223 aa)
CCB66651.1Putative formaldehyde-activating enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (177 aa)
fbiD2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. (230 aa)
CCB66759.1LPPG domain protein containing protein. (326 aa)
cofEF420-0:gamma-glutamyl ligase. (256 aa)
CCB66823.1Putative PQQ-linked dehydrogenase precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (622 aa)
CCB66824.1Extracellular solute-binding protein family 3. (269 aa)
sgaSerine-glyoxylate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (403 aa)
CCB67171.1NADH:flavin oxidoreductase/NADH oxidase. (709 aa)
CCB67172.1NADH:flavin oxidoreductase/NADH oxidase. (688 aa)
CCB67329.1Putative PQQ-linked dehydrogenase precursor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (606 aa)
mgdA-2N-methyl glutamate dehydrogenase/oxidoreductase subunit A; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (420 aa)
CCB67568.1Putative N-methyl glutamate dehydrogenase/oxidoreductase subunit B; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (98 aa)
mgdC-2N-methyl glutamate dehydrogenase/oxidoreductase subunit C; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (994 aa)
CCB67570.1Putative N-methyl glutamate dehydrogenase/oxidoreductase subunit D; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (168 aa)
mgsAN-methyl glutamate synthase subunit A; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (298 aa)
mgsBN-methyl glutamate synthase subunit B; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (228 aa)
mgsCN-methylglutamate synthase subunit C; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the glutamate synthase family. (445 aa)
cbbFFructose-1,6-bisphosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (347 aa)
CCB67601.1Putative phosphoenolpyruvate carboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the PEPCase type 1 family. (950 aa)
mtkBMalate thiokinase, small subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (299 aa)
mtkAMalate thiokinase, large subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
mclmalyl-CoA lyase/beta-methylmalyl-CoA lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the HpcH/HpaI aldolase family. (318 aa)
sga-2Serine-glyoxylate aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (406 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (323 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (224 aa)
acsacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (648 aa)
Your Current Organism:
Hyphomicrobium sp. MC1
NCBI taxonomy Id: 717785
Other names: H. sp. MC1
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