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| | lpxC | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (463 aa) |
| | AL1_00930 | Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (264 aa) |
| | AL1_01100 | Metal-dependent hydrolases of the beta-lactamase superfamily I. (259 aa) |
| | AL1_01760 | Metal-dependent hydrolases of the beta-lactamase superfamily I. (246 aa) |
| | AL1_02050 | Diaminopimelate decarboxylase. (464 aa) |
| | AL1_02460 | Uncharacterised ACR, YkgG family COG1556. (213 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (385 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (175 aa) |
| | uxaC | D-glucuronate isomerase. (470 aa) |
| | AL1_02800 | D-altronate dehydratase. (496 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (284 aa) |
| | glsA | L-glutaminase; Belongs to the glutaminase family. (327 aa) |
| | AL1_03080 | 6-phosphofructokinase. (411 aa) |
| | AL1_03110 | Predicted Fe-S oxidoreductases. (357 aa) |
| | AL1_03190 | Glutamate decarboxylase; Belongs to the group II decarboxylase family. (471 aa) |
| | AL1_03760 | Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). (521 aa) |
| | AL1_03780 | Acetyl/propionyl-CoA carboxylase, alpha subunit. (153 aa) |
| | gpmI | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (509 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (873 aa) |
| | AL1_04240 | Pyruvate dehydrogenase (cytochrome); Belongs to the TPP enzyme family. (578 aa) |
| | AL1_04570 | Glutamate formiminotransferase. (566 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (679 aa) |
| | AL1_04590 | Histidine ammonia-lyase. (493 aa) |
| | hutI | Imidazolonepropionase. (414 aa) |
| | AL1_04860 | Aspartate/tyrosine/aromatic aminotransferase. (395 aa) |
| | AL1_05010 | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa) |
| | glmS | Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (614 aa) |
| | AL1_05100 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (455 aa) |
| | AL1_05290 | Shikimate dehydrogenase. (245 aa) |
| | hisS | histidyl-tRNA synthetase. (448 aa) |
| | pheT | phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (821 aa) |
| | trpB | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (453 aa) |
| | AL1_05600 | Diaminopimelate decarboxylase. (387 aa) |
| | AL1_05620 | Long-chain acyl-CoA synthetases (AMP-forming). (635 aa) |
| | AL1_06540 | Aldo/keto reductases, related to diketogulonate reductase. (280 aa) |
| | gpmA | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa) |
| | AL1_06580 | Fructose-bisphosphate aldolase. (350 aa) |
| | AL1_06680 | Homoserine acetyltransferase. (206 aa) |
| | AL1_06700 | Homoserine dehydrogenase. (402 aa) |
| | AL1_06740 | Uncharacterized conserved protein. (255 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (357 aa) |
| | AL1_08080 | [Acyl-carrier-protein] S-malonyltransferase. (293 aa) |
| | nagB | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. (266 aa) |
| | AL1_08300 | Acetolactate synthase, small subunit. (183 aa) |
| | AL1_08310 | Acetolactate synthase, large subunit. (578 aa) |
| | ilvD | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (608 aa) |
| | AL1_08350 | Threonine synthase. (430 aa) |
| | AL1_10350 | Prephenate dehydratase. (281 aa) |
| | AL1_10360 | Chorismate mutase. (354 aa) |
| | AL1_10540 | 7-keto-8-aminopelargonate synthetase and related enzymes. (423 aa) |
| | AL1_10900 | Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (397 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (494 aa) |
| | uxuA | D-mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (392 aa) |
| | glnS | glutaminyl-tRNA synthetase. (558 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (254 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (508 aa) |
| | AL1_11850 | Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (406 aa) |
| | AL1_12410 | Long-chain acyl-CoA synthetases (AMP-forming). (566 aa) |
| | AL1_12470 | ORF6N domain. (179 aa) |
| | AL1_13010 | Uncharacterized conserved protein; Belongs to the UPF0597 family. (428 aa) |
| | AL1_13070 | Prephenate dehydrogenase. (280 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | AL1_13100 | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (415 aa) |
| | glyQS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (514 aa) |
| | AL1_13210 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (909 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (325 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (414 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (142 aa) |
| | AL1_14040 | Pyruvate kinase; Belongs to the pyruvate kinase family. (491 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (416 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (364 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (539 aa) |
| | AL1_14360 | Predicted Zn-dependent hydrolases of the beta-lactamase fold. (240 aa) |
| | ispH | (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (294 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (395 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (420 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (341 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (680 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (313 aa) |
| | AL1_16200 | Putative Phosphatase. (279 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (293 aa) |
| | AL1_16350 | Asparaginase. (342 aa) |
| | AL1_16690 | NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (460 aa) |
| | AL1_16910 | 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (211 aa) |
| | AL1_16960 | Zn-dependent hydrolases, including glyoxylases. (222 aa) |
| | argH | Argininosuccinate lyase. (418 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (257 aa) |
| | AL1_17560 | N-acetylornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (318 aa) |
| | AL1_17570 | Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (376 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (320 aa) |
| | AL1_17590 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa) |
| | AL1_17600 | Hypothetical protein. (206 aa) |
| | leuS | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (918 aa) |
| | AL1_18090 | Acyl dehydratase. (154 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa) |
| | lysS | Lysyl-tRNA synthetase (class II); Belongs to the class-II aminoacyl-tRNA synthetase family. (572 aa) |
| | AL1_18150 | Predicted membrane protein involved in D-alanine export; Belongs to the membrane-bound acyltransferase family. (501 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (494 aa) |
| | AL1_20170 | Malic enzyme. (426 aa) |
| | AL1_20180 | 3-dehydroquinate synthetase. (233 aa) |
| | AL1_20190 | 3-dehydroquinate synthetase. (107 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (270 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (245 aa) |
| | AL1_21400 | Arginase/agmatinase/formimionoglutamate hydrolase, arginase family; Belongs to the arginase family. (346 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (366 aa) |
| | AL1_21640 | Glutamate dehydrogenase (NAD); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (444 aa) |
| | AL1_22030 | Fructose-bisphosphate aldolase. (333 aa) |
| | AL1_22080 | Malate dehydrogenase (NAD); Belongs to the LDH/MDH superfamily. (332 aa) |
| | AL1_22190 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (117 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (434 aa) |
| | thrS | threonyl-tRNA synthetase /Ser-tRNA(Thr) hydrolase; Belongs to the class-II aminoacyl-tRNA synthetase family. (604 aa) |
| | AL1_22930 | L-lysine 2,3-aminomutase. (699 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa) |
| | AL1_23160 | Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. (294 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa) |
| | AL1_23200 | Tetrahydrodipicolinate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (275 aa) |
| | AL1_23220 | Aspartate kinase; Belongs to the aspartokinase family. (418 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (330 aa) |
| | AL1_23350 | Tyrosine phenol-lyase. (460 aa) |
| | plsX | Phosphate:acyl-[acyl carrier protein] acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (307 aa) |
| | AL1_24780 | Acetyl-CoA hydrolase. (431 aa) |
| | AL1_25300 | Amidohydrolase. (370 aa) |
| | AL1_25310 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (318 aa) |
| | AL1_25320 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1204 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (584 aa) |
| | cysS | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (491 aa) |
| | AL1_25820 | seryl-tRNA synthetase. (423 aa) |
| | AL1_26000 | Hydrogenase 4 membrane component (E). (209 aa) |
| | AL1_26280 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (789 aa) |
| | AL1_26410 | Nucleotide sugar dehydrogenase. (438 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (253 aa) |
| | argS | arginyl-tRNA synthetase. (593 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (353 aa) |
| | AL1_28190 | (R)-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (506 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa) |
| | AL1_28210 | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (458 aa) |
| | AL1_28230 | L-alanine dehydrogenase; Belongs to the AlaDH/PNT family. (368 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (163 aa) |
| | AL1_28690 | Acyl-ACP thioesterase. (242 aa) |
| | AL1_29120 | ORF6N domain. (194 aa) |
| | AL1_29130 | ORF6N domain. (187 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (279 aa) |
| | panD | L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (119 aa) |
| | AL1_29680 | tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (376 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (878 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1131 aa) |
| | AL1_29880 | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (269 aa) |
| | AL1_29930 | Heterodimeric methylmalonyl-CoA mutase small subunit. (615 aa) |
| | AL1_30510 | Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (451 aa) |
| | asnS | asparaginyl-tRNA synthetase. (462 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (472 aa) |
| | AL1_30780 | Phosphoribosylformylglycinamidine synthase. (1239 aa) |
| | carA | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (363 aa) |
| | AL1_31300 | RibD C-terminal domain. (137 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (326 aa) |
| | AL1_31960 | Cysteine synthase. (301 aa) |
| | AL1_32270 | Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (552 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (283 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family. In the N-terminal section; belongs to the histidinol- phosphatase family. (375 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (198 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylidene amino] imidazole-4-carboxamide isomerase. (242 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (250 aa) |
| | hisI | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. (206 aa) |
