(21 nodes) Telomere Extension By Telomerase, and CST complex network (Bos mutus)

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Your Input:
	NOP10	H/ACA ribonucleoprotein complex subunit 3. (64 aa)
	STN1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (371 aa)
	TERF2	Telomeric repeat-binding factor 2. (540 aa)
	NOLC1	Nucleolar and coiled-body phosphoprotein 1. (700 aa)
	M91_15412	Uncharacterized protein. (64 aa)
	ACD	Adrenocortical dysplasia protein-like protein. (455 aa)
	DKC1	H/ACA ribonucleoprotein complex subunit 4. (420 aa)
	NHP2	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
	TEN1	CST complex subunit TEN1. (252 aa)
	POT1	Protection of telomeres protein 1. (473 aa)
	GAR1	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (210 aa)
	TRUB1	Putative tRNA pseudouridine synthase 1. (352 aa)
	TERF1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (438 aa)
	M91_06823	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1232 aa)
	TRUB2	Putative tRNA pseudouridine synthase 2. (331 aa)
	WRAP53	Telomerase Cajal body protein 1. (539 aa)
	TERF2IP	Telomeric repeat-binding factor 2-interacting protein 1. (399 aa)
	CTC1	CST telomere replication complex component 1. (1209 aa)
	SHQ1	Protein SHQ1-like protein. (579 aa)
	NAF1	H/ACA ribonucleoprotein complex non-core subunit NAF1. (38 aa)
	TINF2	TERF1-interacting nuclear factor 2. (463 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	CTC1	ENSBMUP00000004402	ENSBMUP00000029975	Adrenocortical dysplasia protein-like protein.	CST telomere replication complex component 1.	0.531
ACD	DKC1	ENSBMUP00000004402	ENSBMUP00000008882	Adrenocortical dysplasia protein-like protein.	H/ACA ribonucleoprotein complex subunit 4.	0.553
ACD	GAR1	ENSBMUP00000004402	ENSBMUP00000022845	Adrenocortical dysplasia protein-like protein.	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	0.538
ACD	M91_06823	ENSBMUP00000004402	ENSBMUP00000026528	Adrenocortical dysplasia protein-like protein.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.871
ACD	M91_15412	ENSBMUP00000004402	ENSBMUP00000003413	Adrenocortical dysplasia protein-like protein.	Uncharacterized protein.	0.457
ACD	NHP2	ENSBMUP00000004402	ENSBMUP00000010594	Adrenocortical dysplasia protein-like protein.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.553
ACD	NOP10	ENSBMUP00000004402	ENSBMUP00000000574	Adrenocortical dysplasia protein-like protein.	H/ACA ribonucleoprotein complex subunit 3.	0.637
ACD	POT1	ENSBMUP00000004402	ENSBMUP00000022570	Adrenocortical dysplasia protein-like protein.	Protection of telomeres protein 1.	0.997
ACD	STN1	ENSBMUP00000004402	ENSBMUP00000000841	Adrenocortical dysplasia protein-like protein.	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	0.780
ACD	TEN1	ENSBMUP00000004402	ENSBMUP00000012946	Adrenocortical dysplasia protein-like protein.	CST complex subunit TEN1.	0.683
ACD	TERF1	ENSBMUP00000004402	ENSBMUP00000025319	Adrenocortical dysplasia protein-like protein.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.944
ACD	TERF2	ENSBMUP00000004402	ENSBMUP00000001761	Adrenocortical dysplasia protein-like protein.	Telomeric repeat-binding factor 2.	0.980
ACD	TERF2IP	ENSBMUP00000004402	ENSBMUP00000029199	Adrenocortical dysplasia protein-like protein.	Telomeric repeat-binding factor 2-interacting protein 1.	0.983
ACD	TINF2	ENSBMUP00000004402	ENSBMUP00000033472	Adrenocortical dysplasia protein-like protein.	TERF1-interacting nuclear factor 2.	0.997
ACD	TRUB1	ENSBMUP00000004402	ENSBMUP00000024637	Adrenocortical dysplasia protein-like protein.	Putative tRNA pseudouridine synthase 1.	0.437
ACD	WRAP53	ENSBMUP00000004402	ENSBMUP00000028942	Adrenocortical dysplasia protein-like protein.	Telomerase Cajal body protein 1.	0.641
CTC1	ACD	ENSBMUP00000029975	ENSBMUP00000004402	CST telomere replication complex component 1.	Adrenocortical dysplasia protein-like protein.	0.531
CTC1	DKC1	ENSBMUP00000029975	ENSBMUP00000008882	CST telomere replication complex component 1.	H/ACA ribonucleoprotein complex subunit 4.	0.707
CTC1	M91_06823	ENSBMUP00000029975	ENSBMUP00000026528	CST telomere replication complex component 1.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.508
CTC1	M91_15412	ENSBMUP00000029975	ENSBMUP00000003413	CST telomere replication complex component 1.	Uncharacterized protein.	0.445