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| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | MUS81 | Crossover junction endonuclease MUS81. (583 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | PRIMPOL | Coiled-coil domain-containing protein 111. (93 aa) |
| | FBH1 | F-box only protein 18. (1045 aa) |
| | SLX4 | Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12). (1789 aa) |
| | CHTF8 | Chromosome transmission fidelity protein 8. (121 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | FSBP | DNA repair and recombination protein RAD54B. (907 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | RCHY1 | RING finger and CHY zinc finger domain-containing protein 1. (261 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa) |
| | XPA | DNA repair protein complementing XP-A cells. (273 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (816 aa) |
| | MSH3 | DNA mismatch repair protein MSH3. (1016 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1. (279 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1257 aa) |
| | POLD3 | DNA polymerase delta subunit 3. (464 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa) |
| | LOC102276449 | Replication protein A 32 kDa subunit. (270 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | CDC45 | Cell division control protein 45-like protein. (566 aa) |
| | MLH1 | DNA mismatch repair protein MLH1. (703 aa) |
| | ZRANB3 | Zinc finger Ran-binding domain-containing protein 3. (1080 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (982 aa) |
| | MCM6 | Minichromosome maintenance complex component 6. (820 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1. (1521 aa) |
| | XRCC2 | DNA repair protein XRCC2. (280 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (290 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (290 aa) |
| | RPA3 | Replication protein A 14 kDa subunit. (121 aa) |
| | RAD23B | UV excision repair protein RAD23-like protein B. (336 aa) |
| | RMI1 | RecQ-mediated genome instability protein 1. (624 aa) |
| | BLM | Bloom syndrome protein. (1430 aa) |
| | ERCC5 | DNA repair protein complementing XP-G cells. (1201 aa) |
| | BIVM | Basic, immunoglobulin-like variable motif containing. (502 aa) |
| | MLH3 | DNA mismatch repair protein MLH3. (1514 aa) |
| | MCMBP | Uncharacterized protein. (642 aa) |
| | RAD52 | DNA repair protein RAD52-like protein. (416 aa) |
| | ORC4 | Origin recognition complex subunit 4. (455 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | POLD1 | DNA polymerase delta 1, catalytic subunit. (1087 aa) |
| | M91_13835 | Serine-protein kinase ATM. (319 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (987 aa) |
| | WDHD1 | WD repeat and HMG-box DNA-binding protein 1. (1127 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | NBN | Nibrin. (754 aa) |
| | ATAD5 | ATPase family AAA domain-containing protein 5. (1753 aa) |
| | ESCO2 | N-acetyltransferase ESCO2. (590 aa) |
| | SLF1 | Ankyrin repeat domain-containing protein 32. (1055 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (789 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | POLK | DNA polymerase kappa. (910 aa) |
| | ATRIP | ATR interacting protein. (784 aa) |
| | POLH | DNA polymerase eta. (710 aa) |
| | RFC5 | Replication factor C subunit 5. (339 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B. (209 aa) |
| | RAD51B | DNA repair protein RAD51-like protein 2. (365 aa) |
| | ORC3 | Origin recognition complex subunit 3. (712 aa) |
| | RAD51D | RAD51 paralog D. (418 aa) |
| | CDT1 | DNA replication factor Cdt1. (548 aa) |
| | ENSBMUP00000017563 | annotation not available (440 aa) |
| | PIEZO1 | Piezo-type mechanosensitive ion channel component 1/2. (349 aa) |
| | POLE4 | DNA polymerase epsilon subunit 4. (117 aa) |
| | BRCA2 | Breast cancer 2 susceptibility protein. (3374 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | PRIM2 | DNA primase large subunit. (464 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | CDC7 | Cell division control protein 7. (576 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | PMS2 | Mismatch repair endonuclease PMS2. (863 aa) |
| | MCMDC2 | Uncharacterized protein. (681 aa) |
| | RAD50 | DNA repair protein RAD50. (1311 aa) |
| | MSH5 | MutS protein-like protein 5. (832 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4. (1210 aa) |
| | GEN1 | Flap endonuclease GEN-like protein 1. (906 aa) |
| | EXO1 | Exonuclease 1. (833 aa) |
| | RAD23A | UV excision repair protein RAD23-like protein A. (362 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa) |
| | MCM8 | DNA replication licensing factor MCM8; Belongs to the MCM family. (832 aa) |
| | MSH4 | MutS protein-like protein 4. (867 aa) |
| | POLA1 | DNA polymerase. (1468 aa) |
| | MCM10 | Protein MCM10-like protein. (871 aa) |
| | REV3L | DNA polymerase zeta catalytic subunit. (3055 aa) |
| | LIG1 | DNA ligase. (883 aa) |
| | XPC | DNA repair protein complementing XP-C cells. (923 aa) |
| | ORC1 | Origin recognition complex subunit 1. (834 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1207 aa) |
| | MCM2 | Minichromosome maintenance complex component 2. (840 aa) |
| | DDX11 | Putative ATP-dependent RNA helicase DDX11. (901 aa) |
| | RFC4 | Replication factor C subunit 4. (364 aa) |
| | MEIOB | Uncharacterized protein. (472 aa) |
| | RHNO1 | Uncharacterized protein. (241 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (379 aa) |
| | TIMELESS | Protein timeless-like protein. (1218 aa) |
| | RAD54L | DNA repair and recombination protein RAD54-like protein. (749 aa) |
| | WRN | Werner syndrome ATP-dependent helicase. (1426 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa) |
| | POLI | DNA polymerase iota. (635 aa) |
| | RFC1 | Replication factor C subunit 1. (1147 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1828 aa) |
| | ERCC1 | DNA excision repair protein ERCC-1. (304 aa) |
| | ATR | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (328 aa) |
| | CETN2 | Centrin 2. (172 aa) |
| | RAD51C | DNA repair protein RAD51-like protein 3. (441 aa) |
| | MCM3 | Minichromosome maintenance complex component 3. (808 aa) |
| | POLD4 | DNA polymerase delta subunit 4. (178 aa) |
| | RAD9A | RAD9 checkpoint clamp component A. (395 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | XRCC3 | DNA repair protein XRCC3. (136 aa) |
| | ENSBMUP00000028984 | annotation not available (309 aa) |
| | CLSPN | Claspin. (1334 aa) |
| | ENSBMUP00000029030 | annotation not available (99 aa) |
| | ERCC4 | DNA repair endonuclease XPF. (916 aa) |
| | RBBP8 | DNA endonuclease RBBP8. (859 aa) |
| | DBF4 | Protein DBF4-like protein A. (674 aa) |
| | POLE | DNA polymerase epsilon, catalytic subunit. (2285 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (574 aa) |
| | PMS1 | PMS1 homolog 1, mismatch repair system component. (871 aa) |
| | BARD1 | BRCA1-associated RING domain protein 1. (773 aa) |
| | PALB2 | PALB2_WD40 domain-containing protein. (1195 aa) |
| | DNA2 | DNA replication ATP-dependent helicase Dna2. (1061 aa) |
| | POLE3 | DNA polymerase epsilon subunit 3. (145 aa) |
| | LOC102279735 | Serine/threonine-protein kinase Chk1. (227 aa) |
| | CHD1L | Chromodomain-helicase-DNA-binding protein 1-like protein. (895 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | CHTF18 | Chromosome transmission fidelity protein 18-like protein. (970 aa) |
| | M91_12513 | Methylated-DNA--protein-cysteine methyltransferase. (143 aa) |
| | GINS1 | DNA replication complex GINS protein PSF1. (178 aa) |
| | MCM9 | DNA replication licensing factor MCM9; Belongs to the MCM family. (1139 aa) |
| | RAD17 | Cell cycle checkpoint protein RAD17. (708 aa) |
| | TDRD3 | Tudor domain-containing protein 3. (651 aa) |
| | ENSBMUP00000033156 | annotation not available (219 aa) |
| | ENSBMUP00000035179 | annotation not available (199 aa) |
| | POLD2 | DNA polymerase delta subunit 2. (469 aa) |
| | SLX1A | SLX1 homolog A, structure-specific endonuclease subunit. (156 aa) |
| | DMC1 | Meiotic recombination protein DMC1/LIM15-like protein; Belongs to the RecA family. (340 aa) |
| | ORC2 | Origin recognition complex subunit 2. (576 aa) |
