(8 nodes) DNA replication initiation network (Bos mutus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POLA2	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa)
	POLE4	DNA polymerase epsilon subunit 4. (117 aa)
	PRIM2	DNA primase large subunit. (464 aa)
	POLA1	DNA polymerase. (1468 aa)
	PRIM1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	POLE	DNA polymerase epsilon, catalytic subunit. (2285 aa)
	POLE3	DNA polymerase epsilon subunit 3. (145 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
POLA1	POLA2	ENSBMUP00000021592	ENSBMUP00000003057	DNA polymerase.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.999
POLA1	POLE	ENSBMUP00000021592	ENSBMUP00000029510	DNA polymerase.	DNA polymerase epsilon, catalytic subunit.	0.982
POLA1	POLE2	ENSBMUP00000021592	ENSBMUP00000028900	DNA polymerase.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.973
POLA1	POLE3	ENSBMUP00000021592	ENSBMUP00000031297	DNA polymerase.	DNA polymerase epsilon subunit 3.	0.911
POLA1	POLE4	ENSBMUP00000021592	ENSBMUP00000017976	DNA polymerase.	DNA polymerase epsilon subunit 4.	0.888
POLA1	PRIM1	ENSBMUP00000021592	ENSBMUP00000025021	DNA polymerase.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.998
POLA1	PRIM2	ENSBMUP00000021592	ENSBMUP00000018539	DNA polymerase.	DNA primase large subunit.	0.999
POLA2	POLA1	ENSBMUP00000003057	ENSBMUP00000021592	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	DNA polymerase.	0.999
POLA2	POLE	ENSBMUP00000003057	ENSBMUP00000029510	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	DNA polymerase epsilon, catalytic subunit.	0.956
POLA2	POLE2	ENSBMUP00000003057	ENSBMUP00000028900	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.902
POLA2	POLE3	ENSBMUP00000003057	ENSBMUP00000031297	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	DNA polymerase epsilon subunit 3.	0.775
POLA2	POLE4	ENSBMUP00000003057	ENSBMUP00000017976	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	DNA polymerase epsilon subunit 4.	0.737
POLA2	PRIM1	ENSBMUP00000003057	ENSBMUP00000025021	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.998
POLA2	PRIM2	ENSBMUP00000003057	ENSBMUP00000018539	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	DNA primase large subunit.	0.998
POLE	POLA1	ENSBMUP00000029510	ENSBMUP00000021592	DNA polymerase epsilon, catalytic subunit.	DNA polymerase.	0.982
POLE	POLA2	ENSBMUP00000029510	ENSBMUP00000003057	DNA polymerase epsilon, catalytic subunit.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.956
POLE	POLE2	ENSBMUP00000029510	ENSBMUP00000028900	DNA polymerase epsilon, catalytic subunit.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.999
POLE	POLE3	ENSBMUP00000029510	ENSBMUP00000031297	DNA polymerase epsilon, catalytic subunit.	DNA polymerase epsilon subunit 3.	0.999
POLE	POLE4	ENSBMUP00000029510	ENSBMUP00000017976	DNA polymerase epsilon, catalytic subunit.	DNA polymerase epsilon subunit 4.	0.994
POLE	PRIM1	ENSBMUP00000029510	ENSBMUP00000025021	DNA polymerase epsilon, catalytic subunit.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.949