STRINGSTRING
M91_11341 M91_11341 RNF169 RNF169 ABRAXAS1 ABRAXAS1 UBE2N UBE2N BRCC3 BRCC3 MDC1 MDC1 ENSBMUP00000009984 ENSBMUP00000009984 UBE2V2 UBE2V2 BABAM2 BABAM2 RNF8 RNF8 UIMC1 UIMC1 RIF1 RIF1 TP53BP1 TP53BP1 BABAM1 BABAM1 RNF168 RNF168 PAXIP1 PAXIP1 M91_19001 M91_19001 CHEK2 CHEK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
M91_11341Histone H2A; Belongs to the histone H2A family. (145 aa)
RNF169RING finger protein 169. (708 aa)
ABRAXAS1BRCA1-A complex subunit Abraxas. (428 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36. (291 aa)
MDC1Mediator of DNA damage checkpoint protein 1. (1065 aa)
ENSBMUP00000009984annotation not available (144 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
BABAM2BRCA1-A complex subunit BRE. (383 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa)
UIMC1Uncharacterized protein. (225 aa)
RIF1Replication timing regulatory factor 1. (2465 aa)
TP53BP1Tumor suppressor p53-binding protein 1. (1965 aa)
BABAM1BRISC and BRCA1 A complex member 1. (332 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
PAXIP1PAX-interacting protein 1. (974 aa)
M91_19001BRCA1-A complex subunit RAP80. (201 aa)
CHEK2Checkpoint kinase 2. (441 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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