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GTPBP6 GTPBP6 TYW5 TYW5 TRMT10B TRMT10B METTL8 METTL8 TARBP1 TARBP1 TSTD2 TSTD2 DUS2 DUS2 TRMO TRMO LOC102274921 LOC102274921 LOC102271688 LOC102271688 THUMPD1 THUMPD1 ENSBMUP00000004790 ENSBMUP00000004790 QTRT1 QTRT1 RPUSD4 RPUSD4 PUS10 PUS10 TRMT2A TRMT2A MTFMT MTFMT YRDC YRDC TRMT13 TRMT13 FTSJ1 FTSJ1 THUMPD2 THUMPD2 DTWD2 DTWD2 ELP5 ELP5 ENSBMUP00000008796 ENSBMUP00000008796 ENSBMUP00000008924 ENSBMUP00000008924 ANKRD16 ANKRD16 ELP1 ELP1 C9orf64 C9orf64 ADAT2 ADAT2 ELP4 ELP4 DUS4L DUS4L PUS7 PUS7 TRDMT1 TRDMT1 NAT10 NAT10 TRMT10A TRMT10A NSUN6 NSUN6 TRMT9B TRMT9B LOC102280017 LOC102280017 TRMT10C TRMT10C METTL6 METTL6 ELP3 ELP3 M91_19109 M91_19109 TRMT44 TRMT44 ENSBMUP00000014714 ENSBMUP00000014714 MOCS3 MOCS3 AARS2 AARS2 LYRM9 LYRM9 THUMPD3 THUMPD3 OSGEP OSGEP TPRKB TPRKB WDR4 WDR4 TRMT61B TRMT61B CDKAL1 CDKAL1 ELP6 ELP6 CTU2 CTU2 TRMT11 TRMT11 WDR6 WDR6 DALRD3 DALRD3 ELP2 ELP2 TRMT112 TRMT112 THG1L THG1L GON7 GON7 TRMT1 TRMT1 NSUN3 NSUN3 TRMT6 TRMT6 TYW3 TYW3 QTRT2 QTRT2 LOC102265557 LOC102265557 TRMU TRMU ALKBH1 ALKBH1 TRUB1 TRUB1 HSD17B10 HSD17B10 MTO1 MTO1 GTPBP3 GTPBP3 URM1 URM1 TRMT61A TRMT61A TRMT1L TRMT1L DPH3 DPH3 ENSBMUP00000029771 ENSBMUP00000029771 PUS1 PUS1 OSGEPL1 OSGEPL1 AARS1 AARS1 DTWD1 DTWD1 BCDIN3D BCDIN3D TRIT1 TRIT1 ENSBMUP00000032357 ENSBMUP00000032357 PUSL1 PUSL1 TRMT12 TRMT12 NSUN2 NSUN2 CDK5RAP1 CDK5RAP1 METTL2A METTL2A THADA THADA TRMT5 TRMT5 METTL1 METTL1 ENSBMUP00000034603 ENSBMUP00000034603 DUS3L DUS3L ENSBMUP00000035361 ENSBMUP00000035361 DUS1L DUS1L PUS3 PUS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GTPBP6Putative GTP-binding protein 6. (566 aa)
TYW5JmjC domain-containing protein. (315 aa)
TRMT10BRNA (Guanine-9-)-methyltransferase domain-containing protein 3. (316 aa)
METTL8Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (407 aa)
TARBP1Putative methyltransferase TARBP1. (1602 aa)
TSTD2Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2. (513 aa)
DUS2tRNA-dihydrouridine synthase 2-like protein. (493 aa)
TRMONef-associated protein 1. (435 aa)
LOC102274921tRNA wybutosine-synthesizing protein 1-like protein. (731 aa)
LOC102271688CheR domain-containing protein. (282 aa)
THUMPD1THUMP domain-containing protein 1. (356 aa)
ENSBMUP00000004790annotation not available (116 aa)
QTRT1Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (395 aa)
RPUSD4RNA pseudouridylate synthase domain-containing protein 4. (377 aa)
PUS10Putative tRNA pseudouridine synthase Pus10. (532 aa)
TRMT2AtRNA (Uracil-5-)-methyltransferase-like protein A; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (628 aa)
MTFMTMethionyl-tRNA formyltransferase, mitochondrial. (442 aa)
YRDCYrdC domain-containing protein, mitochondrial. (278 aa)
TRMT13tRNA guanosine-2'-O-methyltransferase TRM13-like protein. (481 aa)
FTSJ1Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (329 aa)
THUMPD2THUMP domain-containing protein 2. (501 aa)
DTWD2DTW domain-containing protein 2. (298 aa)
ELP5Dermal papilla-derived protein 6. (222 aa)
ENSBMUP00000008796annotation not available (123 aa)
ENSBMUP00000008924annotation not available (63 aa)
ANKRD16Ankyrin repeat domain-containing protein 16. (360 aa)
ELP1Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1332 aa)
C9orf64Queuosine salvage protein; Involved in salvaging queuosine. (341 aa)
ADAT2tRNA-specific adenosine deaminase 2. (191 aa)
ELP4Elongator complex protein 4. (475 aa)
DUS4LtRNA-dihydrouridine synthase 4-like protein. (320 aa)
PUS7Pseudouridylate synthase 7-like protein. (717 aa)
TRDMT1tRNA (Cytosine-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (391 aa)
NAT10N-acetyltransferase 10. (1026 aa)
TRMT10ARNA (Guanine-9-)-methyltransferase domain-containing protein 2. (338 aa)
NSUN6Putative methyltransferase NSUN6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (470 aa)
TRMT9BPutative methyltransferase KIAA1456-like protein. (424 aa)
LOC102280017Alkylated DNA repair protein alkB homolog 8-like. (238 aa)
TRMT10CMitochondrial ribonuclease P protein 1. (426 aa)
METTL6Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (307 aa)
ELP3Elongator complex protein 3. (547 aa)
M91_19109Alkylated DNA repair protein alkB-like protein 8. (214 aa)
TRMT44Putative tRNA (Uracil-O(2)-)-methyltransferase. (399 aa)
ENSBMUP00000014714annotation not available (154 aa)
MOCS3Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (455 aa)
AARS2Alanyl-tRNA synthetase, mitochondrial. (983 aa)
LYRM9Uncharacterized protein; Belongs to the complex I LYR family. (172 aa)
THUMPD3THUMP domain-containing protein 3. (503 aa)
OSGEPProbable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (335 aa)
TPRKBTP53RK-binding protein; Belongs to the CGI121/TPRKB family. (175 aa)
WDR4tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (453 aa)
TRMT61BPutative tRNA (Adenine-N(1)-)-methyltransferase catalytic subunit TRMT61B. (496 aa)
CDKAL1CDK5 regulatory subunit-associated protein 1-like 1. (98 aa)
ELP6Uncharacterized protein. (164 aa)
CTU2Cytosolic thiouridylase subunit 2. (526 aa)
TRMT11tRNA guanosine-2'-O-methyltransferase TRM11-like protein. (459 aa)
WDR6WD repeat domain 6. (1181 aa)
DALRD3DALR anticodon-binding domain-containing protein 3. (541 aa)
ELP2Elongator complex protein 2. (826 aa)
TRMT112tRNA methyltransferase 112-like protein. (125 aa)
THG1LtRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (298 aa)
GON7Uncharacterized protein. (99 aa)
TRMT1N(2),N(2)-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (676 aa)
NSUN3Putative methyltransferase NSUN3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (340 aa)
TRMT6tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (497 aa)
TYW3tRNA wybutosine-synthesizing protein 3-like protein. (258 aa)
QTRT2Queuine tRNA-ribosyltransferase accessory subunit 2. (415 aa)
LOC102265557TRAM domain-containing protein. (323 aa)
TRMUMitochondrial tRNA-specific 2-thiouridylase 1. (456 aa)
ALKBH1Alkylated DNA repair protein alkB-like protein 1. (389 aa)
TRUB1Putative tRNA pseudouridine synthase 1. (352 aa)
HSD17B103-hydroxyacyl-CoA dehydrogenase type-2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
MTO1Protein MTO1-like protein, mitochondrial. (692 aa)
GTPBP3GTP binding protein 3 (mitochondrial). (574 aa)
URM1Ubiquitin-related modifier 1; Belongs to the URM1 family. (101 aa)
TRMT61AtRNA (Adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A. (300 aa)
TRMT1LTRM1-like protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (737 aa)
DPH3DPH3-like protein. (128 aa)
ENSBMUP00000029771annotation not available (100 aa)
PUS1tRNA pseudouridine synthase A, mitochondrial. (433 aa)
OSGEPL1Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (414 aa)
AARS1Alanyl-tRNA synthetase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
DTWD1DTW domain-containing protein 1. (301 aa)
BCDIN3DPutative methyltransferase BCDIN3D. (393 aa)
TRIT1tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (467 aa)
ENSBMUP00000032357annotation not available (176 aa)
PUSL1tRNA pseudouridine synthase. (287 aa)
TRMT12tRNA wybutosine-synthesizing protein 2-like protein. (462 aa)
NSUN2tRNA (Cytosine-5-)-methyltransferase NSUN2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (840 aa)
CDK5RAP1CDK5 regulatory subunit-associated protein 1. (603 aa)
METTL2AMethyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (378 aa)
THADATHADA, armadillo repeat containing. (1951 aa)
TRMT5tRNA (Guanine-N(1)-)-methyltransferase. (497 aa)
METTL1tRNA (guanine(46)-N(7))-methyltransferase. (277 aa)
ENSBMUP00000034603annotation not available (82 aa)
DUS3LDihydrouridine synthase 3 like. (648 aa)
ENSBMUP00000035361annotation not available (77 aa)
DUS1LtRNA-dihydrouridine synthase 1-like protein. (475 aa)
PUS3tRNA pseudouridine synthase 3. (481 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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