104 items (Bos mutus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NCOA4	Nuclear receptor coactivator 4. (631 aa)
	GRN	Granulin precursor. (587 aa)
	VPS16	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa)
	HGSNAT	Heparan-alpha-glucosaminide N-acetyltransferase. (631 aa)
	EHD3	EH domain-containing protein 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
	HOOK3	Protein Hook-like protein 3. (699 aa)
	UEVLD	Ubiquitin-conjugating enzyme E2 variant 3. (471 aa)
	TSG101	Tumor susceptibility 101 protein. (420 aa)
	CHMP2A	Charged multivesicular body protein 2a. (222 aa)
	VPS54	Vacuolar protein sorting-associated protein 54. (965 aa)
	PINK1	Serine/threonine-protein kinase PINK1, mitochondrial; Belongs to the protein kinase superfamily. (468 aa)
	LAMP2	Lysosome-associated membrane glycoprotein 2. (452 aa)
	ENSBMUP00000030625	annotation not available (81 aa)
	CDX2	Homeobox protein CDX-2. (138 aa)
	VCP	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (806 aa)
	AP4M1	AP-4 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (452 aa)
	SCYL2	SCY1-like protein 2. (933 aa)
	TMEM106B	Transmembrane protein 106B. (275 aa)
	SNX27	Sorting nexin-27. (552 aa)
	ENSBMUP00000033219	annotation not available (218 aa)
	CACNG7	Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
	CACNG2	Calcium voltage-gated channel auxiliary subunit gamma 2. (294 aa)
	MVB12A	Multivesicular body subunit 12A. (255 aa)
	CHMP4A	Charged multivesicular body protein 4A. (222 aa)
	BIN1	Myc box-dependent-interacting protein 1. (602 aa)
	GUSB	Beta-glucuronidase-like. (498 aa)
	GAK	Cyclin-G-associated kinase. (1239 aa)
	CACNG5	Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
	CACNG4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (266 aa)
	SNX16	Sorting nexin-16. (343 aa)
	CHMP4C	Charged multivesicular body protein 4c. (236 aa)
	HGS	Hepatocyte growth factor-regulated tyrosine kinase substrate. (710 aa)
	SNAPIN	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
	PLEKHF2	Pleckstrin-like protein domain-containing family F member 2. (249 aa)
	ZFYVE16	Zinc finger FYVE domain-containing protein 16. (1546 aa)
	VPS4B	Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (445 aa)
	IGF2R	Cation-independent mannose-6-phosphate receptor. (2493 aa)
	MTM1	Myotubularin. (603 aa)
	LOC102284805	RBR-type E3 ubiquitin transferase. (176 aa)
	VPS51	Protein fat-free-like protein. (781 aa)
	SORT1	Sortilin. (831 aa)
	M91_13158	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (279 aa)
	LOC102278697	Heat shock 70 kDa protein 1A; Belongs to the heat shock protein 70 family. (599 aa)
	LOC102278977	Heat shock 70 kDa protein 1B; Belongs to the heat shock protein 70 family. (633 aa)
	CHMP2B	Charged multivesicular body protein 2b. (213 aa)
	VPS41	Vacuolar protein sorting-associated protein 41-like protein. (854 aa)
	M6PR	Cation-dependent mannose-6-phosphate receptor. (279 aa)
	TPCN2	Two pore calcium channel protein 2. (712 aa)
	AP1G1	AP-1 complex subunit gamma-1. (825 aa)
	PLEKHF1	Pleckstrin-like protein domain-containing family F member 1. (279 aa)
	GCC2	GRIP and coiled-coil domain-containing protein 2. (1700 aa)
	GGA3	ADP-ribosylation factor-binding protein GGA3. (703 aa)
	VPS52	Vacuolar protein sorting-associated protein 52-like protein. (723 aa)
	NEDD4	E3 ubiquitin-protein ligase NEDD4. (1321 aa)
	LYST	Lysosomal trafficking regulator. (3799 aa)
	CCDC91	Coiled-coil domain-containing protein 91. (449 aa)
	EPG5	UPF0493 protein KIAA1632. (2524 aa)
	SORL1	Sortilin related receptor 1. (2123 aa)
	LOC102270304	E3 ubiquitin-protein ligase parkin. (279 aa)
	GNPTAB	N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. (1249 aa)
	ATG14	Beclin 1-associated autophagy-related key regulator. (552 aa)
	VPS53	Vacuolar protein sorting-associated protein 53-like protein. (832 aa)
	HOOK1	Protein Hook-like protein 1. (728 aa)
	VAMP7	Vesicle associated membrane protein 7. (240 aa)
	LOC102284329	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (674 aa)
	AKTIP	AKT-interacting protein. (293 aa)
	ANKFY1	Ankyrin repeat and FYVE domain-containing protein 1. (1170 aa)
	CLN3	Battenin. (438 aa)
	PLEKHM1	Pleckstrin-like protein domain-containing family M member 1. (1055 aa)
	CHMP3	Charged multivesicular body protein 3. (222 aa)
	VPS4A	Vacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (467 aa)
	HSPA8	Heat shock protein family A (Hsp70) member 8. (646 aa)
	TGFBRAP1	Transforming growth factor beta receptor associated protein 1. (803 aa)
	RNF157	Ring finger protein 157. (686 aa)
	MGRN1	E3 ubiquitin-protein ligase MGRN1. (575 aa)
	VPS35	Vacuolar protein sorting-associated protein 35. (796 aa)
	CHMP1A	Charged multivesicular body protein 1a. (132 aa)
	ENSBMUP00000016419	annotation not available (132 aa)
	DENND3	DENN domain-containing protein 3. (1249 aa)
	LAMP1	Lysosome-associated membrane glycoprotein 1. (427 aa)
	FAM160A2	FTS and Hook-interacting protein. (986 aa)
	AP3B1	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1085 aa)
	AP3D1	AP-3 complex subunit delta-1. (1203 aa)
	HMGXB4	HMG domain-containing protein 4. (611 aa)
	DTX3L	E3 ubiquitin-protein ligase DTX3L. (226 aa)
	RAB7A	Ras-related protein Rab-7a. (247 aa)
	SCARB2	Lysosome membrane protein 2; Belongs to the CD36 family. (478 aa)
	HOOK2	Protein Hook-like protein 2. (696 aa)
	BECN2	Beclin-1-like protein 1. (439 aa)
	CLEC16A	Protein CLEC16A. (1050 aa)
	CHMP1B	Charged multivesicular body protein 1b. (199 aa)
	TRAK1	Trafficking kinesin-binding protein 1. (954 aa)
	CHMP5	Charged multivesicular body protein 5. (219 aa)
	PSAP	Proactivator polypeptide. (525 aa)
	VPS33A	Vacuolar protein sorting-associated protein 33A; Belongs to the STXBP/unc-18/SEC1 family. (596 aa)
	ALS2	Alsin. (1656 aa)
	RBSN	Rabenosyn-5. (783 aa)
	RAB7B	Ras-related protein Rab-7b. (197 aa)
	CHMP6	Charged multivesicular body protein 6. (201 aa)
	VIPAS39	VPS33B-interacting protein. (492 aa)
	VPS18	Vacuolar protein sorting-associated protein 18-like protein. (973 aa)
	CHMP7	Charged multivesicular body protein 7. (453 aa)
	UBXN6	UBX domain-containing protein 6. (441 aa)
	VPS39	Vam6/Vps39-like protein. (875 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKTIP	FAM160A2	ENSBMUP00000013785	ENSBMUP00000018303	AKT-interacting protein.	FTS and Hook-interacting protein.	0.868
AKTIP	HOOK1	ENSBMUP00000013785	ENSBMUP00000013026	AKT-interacting protein.	Protein Hook-like protein 1.	0.915
AKTIP	HOOK2	ENSBMUP00000013785	ENSBMUP00000019410	AKT-interacting protein.	Protein Hook-like protein 2.	0.833
AKTIP	HOOK3	ENSBMUP00000013785	ENSBMUP00000027699	AKT-interacting protein.	Protein Hook-like protein 3.	0.921
AKTIP	VPS18	ENSBMUP00000013785	ENSBMUP00000024334	AKT-interacting protein.	Vacuolar protein sorting-associated protein 18-like protein.	0.461
ALS2	AP4M1	ENSBMUP00000023462	ENSBMUP00000031740	Alsin.	AP-4 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.509
ALS2	CHMP2B	ENSBMUP00000023462	ENSBMUP00000005585	Alsin.	Charged multivesicular body protein 2b.	0.530
ALS2	VCP	ENSBMUP00000023462	ENSBMUP00000031242	Alsin.	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family.	0.470
ANKFY1	AP3B1	ENSBMUP00000013787	ENSBMUP00000018310	Ankyrin repeat and FYVE domain-containing protein 1.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.467
ANKFY1	EHD3	ENSBMUP00000013787	ENSBMUP00000027949	Ankyrin repeat and FYVE domain-containing protein 1.	EH domain-containing protein 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.476
ANKFY1	RBSN	ENSBMUP00000013787	ENSBMUP00000023574	Ankyrin repeat and FYVE domain-containing protein 1.	Rabenosyn-5.	0.635
AP1G1	AP3B1	ENSBMUP00000007819	ENSBMUP00000018310	AP-1 complex subunit gamma-1.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.833
AP1G1	AP3D1	ENSBMUP00000007819	ENSBMUP00000018415	AP-1 complex subunit gamma-1.	AP-3 complex subunit delta-1.	0.489
AP1G1	AP4M1	ENSBMUP00000007819	ENSBMUP00000031740	AP-1 complex subunit gamma-1.	AP-4 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.871
AP1G1	CHMP2A	ENSBMUP00000007819	ENSBMUP00000029123	AP-1 complex subunit gamma-1.	Charged multivesicular body protein 2a.	0.601
AP1G1	GAK	ENSBMUP00000007819	ENSBMUP00000034312	AP-1 complex subunit gamma-1.	Cyclin-G-associated kinase.	0.938
AP1G1	HGS	ENSBMUP00000007819	ENSBMUP00000035525	AP-1 complex subunit gamma-1.	Hepatocyte growth factor-regulated tyrosine kinase substrate.	0.640
AP1G1	IGF2R	ENSBMUP00000007819	ENSBMUP00000003896	AP-1 complex subunit gamma-1.	Cation-independent mannose-6-phosphate receptor.	0.536
AP1G1	M6PR	ENSBMUP00000007819	ENSBMUP00000007079	AP-1 complex subunit gamma-1.	Cation-dependent mannose-6-phosphate receptor.	0.442
AP1G1	SNAPIN	ENSBMUP00000007819	ENSBMUP00000036076	AP-1 complex subunit gamma-1.	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...]	0.533