STRINGSTRING
RGL1 RGL1 SOS2 SOS2 BRAP BRAP RAB35 RAB35 DNMT1 DNMT1 RASSF1 RASSF1 KRAS KRAS ZNF304 ZNF304 GNA12 GNA12 ENSBMUP00000026331 ENSBMUP00000026331 TMEM19 TMEM19 RAB21 RAB21 EPS8L1 EPS8L1 RALB RALB RASGEF1B RASGEF1B RHOV RHOV C15orf62 C15orf62 PLCE1 PLCE1 ROCK2 ROCK2 ARHGAP5 ARHGAP5 ENSBMUP00000023933 ENSBMUP00000023933 RAB15 RAB15 KITLG-2 KITLG-2 KITLG KITLG PHACTR4 PHACTR4 RASGRP3 RASGRP3 RAP2B RAP2B CDK2 CDK2 WASF1 WASF1 NCKAP1 NCKAP1 PLEKHG7 PLEKHG7 WASF2 WASF2 LOC102278780 LOC102278780 NKIRAS2 NKIRAS2 CNKSR1 CNKSR1 RHOH RHOH ARHGEF11 ARHGEF11 LOC102288172 LOC102288172 RAB12 RAB12 RAPGEFL1 RAPGEFL1 ENSBMUP00000004992 ENSBMUP00000004992 RRAS RRAS GPSM2 GPSM2 SGSM3 SGSM3 RALA RALA RALGDS RALGDS BRK1 BRK1 USP50 USP50 RAB30 RAB30 CYFIP1 CYFIP1 RAP2C RAP2C ARHGEF12 ARHGEF12 RAP1A RAP1A RHOG RHOG CCNA2 CCNA2 RRAS2 RRAS2 NGFR NGFR RASGRP1 RASGRP1 ARHGDIB ARHGDIB RERG RERG PLEKHG5 PLEKHG5 KPNB1 KPNB1 ADGRG1 ADGRG1 RAPGEF4 RAPGEF4 RB1 RB1 RASGRP2 RASGRP2 RHOA RHOA MRAS MRAS NRAS NRAS EPS8 EPS8 SOS1 SOS1 HRAS HRAS RHOU RHOU EPS8L2 EPS8L2 CDC42EP3 CDC42EP3 RAPGEF1 RAPGEF1 WAS WAS ERAS ERAS HACD3 HACD3 ARHGAP35 ARHGAP35 COL1A2 COL1A2 RFXANK RFXANK DGKI DGKI CDC42 CDC42 IQGAP3 IQGAP3 RAPGEF3 RAPGEF3 RASGRP4 RASGRP4 LAT LAT CDC42EP2 CDC42EP2 RASGRF2 RASGRF2 RAB39A RAB39A SYNGAP1 SYNGAP1 CDC42EP1 CDC42EP1 RGL2 RGL2 JUN JUN RAB9B RAB9B DOK3 DOK3 ELMO1 ELMO1 NISCH NISCH RAB39B RAB39B PRKD1 PRKD1 EPS8L3 EPS8L3 DBNL DBNL M91_05661 M91_05661 RACGAP1 RACGAP1 RAB9A RAB9A RAP2A RAP2A PDIA2 PDIA2 GDI1 GDI1 RALGPS2 RALGPS2 PDPN PDPN RASGRF1 RASGRF1 ARHGDIA ARHGDIA SHTN1 SHTN1 CDH13 CDH13 ENSBMUP00000034400 ENSBMUP00000034400 GNA13 GNA13 MAPKAPK5 MAPKAPK5 ENSBMUP00000033847 ENSBMUP00000033847 RAPGEF2 RAPGEF2 MYO9B MYO9B RAC2 RAC2 ARHGDIG ARHGDIG CSF1 CSF1 RANGRF RANGRF DOK1 DOK1 SYNJ2BP SYNJ2BP RIT1 RIT1 AIF1 AIF1 RAB33A RAB33A ENSBMUP00000018435 ENSBMUP00000018435 RHOJ RHOJ LOC102269967 LOC102269967 TP53 TP53 RAPGEF5 RAPGEF5 ENSBMUP00000014878 ENSBMUP00000014878 TRIM28 TRIM28 ROCK1 ROCK1 AGTR1 AGTR1 DOK2 DOK2 ITGA3 ITGA3 KIAA0355 KIAA0355 USP8 USP8 RAB4B RAB4B ENSBMUP00000014870 ENSBMUP00000014870 NF1 NF1 RIPOR1 RIPOR1 CDC42EP4 CDC42EP4 RABGEF1 RABGEF1 LOC102284736 LOC102284736 RAP1B RAP1B RAB33B RAB33B KSR1 KSR1 ENSBMUP00000015288 ENSBMUP00000015288 TAX1BP3 TAX1BP3 RAB4A RAB4A RASGEF1C RASGEF1C BCL6 BCL6 NKIRAS1 NKIRAS1 KSR2 KSR2 CDKN1A CDKN1A RASGEF1A RASGEF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RGL1Ral guanine nucleotide dissociation stimulator-like 1. (843 aa)
SOS2Son of sevenless-like protein 2. (1272 aa)
BRAPBRCA1-associated protein. (569 aa)
RAB35Ras-related protein Rab-35. (216 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1696 aa)
RASSF1Ras association domain-containing protein 1. (344 aa)
KRASGTPase KRas. (189 aa)
ZNF304Zinc finger protein 304. (619 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (291 aa)
ENSBMUP00000026331annotation not available (63 aa)
TMEM19Transmembrane protein 19. (336 aa)
RAB21Ras-related protein Rab-21. (215 aa)
EPS8L1Epidermal growth factor receptor kinase substrate 8-like protein 1. (677 aa)
RALBRas-related protein Ral-B. (234 aa)
RASGEF1BRas-GEF domain-containing family member 1B. (558 aa)
RHOVRho-related GTP-binding protein RhoV. (236 aa)
C15orf62Chromosome unknown open reading frame, human C15orf62. (176 aa)
PLCE1Phosphoinositide phospholipase C. (1785 aa)
ROCK2Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1297 aa)
ARHGAP5Rho GTPase activating protein 5. (1492 aa)
ENSBMUP00000023933annotation not available (93 aa)
RAB15RAB15, member RAS oncogene family. (237 aa)
KITLG-2Kit ligand. (196 aa)
KITLGKIT ligand. (90 aa)
PHACTR4Phosphatase and actin regulator. (717 aa)
RASGRP3Ras guanyl-releasing protein 3. (692 aa)
RAP2BRas-related protein Rap-2b. (183 aa)
CDK2Cell division protein kinase 2; Belongs to the protein kinase superfamily. (346 aa)
WASF1Wiskott-Aldrich syndrome protein family member 1. (559 aa)
NCKAP1Nck-associated protein 1. (1028 aa)
PLEKHG7Pleckstrin-like protein domain-containing family G member 7. (379 aa)
WASF2Wiskott-Aldrich syndrome protein family member 2. (493 aa)
LOC102278780Cadherin EGF LAG seven-pass G-type receptor 1. (1838 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2. (191 aa)
CNKSR1Connector enhancer of kinase suppressor of ras 1. (718 aa)
RHOHRho-related GTP-binding protein RhoH. (191 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1560 aa)
LOC102288172Tumor necrosis factor receptor superfamily member 16. (241 aa)
RAB12Ras-related protein Rab-12. (243 aa)
RAPGEFL1Rap guanine nucleotide exchange factor like 1. (488 aa)
ENSBMUP00000004992annotation not available (177 aa)
RRASRas-related protein R-Ras. (218 aa)
GPSM2G-protein-signaling modulator 2. (684 aa)
SGSM3Small G protein signaling modulator 3. (745 aa)
RALARas-related protein Ral-A. (206 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (874 aa)
BRK1Uncharacterized protein. (75 aa)
USP50Putative ubiquitin carboxyl-terminal hydrolase 50; Belongs to the peptidase C19 family. (310 aa)
RAB30Ras-related protein Rab-30. (203 aa)
CYFIP1Cytoplasmic FMR1-interacting protein 1. (1253 aa)
RAP2CRas-related protein Rap-2c. (183 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1549 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
RHOGRho-related GTP-binding protein RhoG. (191 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (417 aa)
RRAS2Ras-related protein R-Ras2. (173 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (428 aa)
RASGRP1RAS guanyl-releasing protein 1. (797 aa)
ARHGDIBRho GDP-dissociation inhibitor 2. (200 aa)
RERGRas-related and estrogen-regulated growth inhibitor. (189 aa)
PLEKHG5Pleckstrin-like protein domain-containing family G member 5. (1083 aa)
KPNB1Importin subunit beta-1. (876 aa)
ADGRG1G-protein coupled receptor 56; Belongs to the G-protein coupled receptor 2 family. (695 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1007 aa)
RB1Retinoblastoma-associated protein. (880 aa)
RASGRP2RAS guanyl releasing protein 2. (608 aa)
RHOATransforming protein RhoA. (193 aa)
MRASRas-related protein M-Ras. (208 aa)
NRASGTPase NRas. (189 aa)
EPS8Epidermal growth factor receptor kinase substrate 8. (862 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
RHOURho-related GTP-binding protein RhoU. (257 aa)
EPS8L2EPS8 like 2. (561 aa)
CDC42EP3Cdc42 effector protein 3. (254 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
WASWiskott-Aldrich syndrome protein. (514 aa)
ERASGTPase ERas. (234 aa)
HACD3Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (362 aa)
ARHGAP35Glucocorticoid receptor DNA-binding factor 1. (1500 aa)
COL1A2Collagen alpha-2(I) chain. (1364 aa)
RFXANKDNA-binding protein RFXANK. (260 aa)
DGKIDiacylglycerol kinase (ATP). (1075 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1615 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
RASGRP4RAS guanyl-releasing protein 4. (673 aa)
LATLinker for activation of T-cells family member 1. (280 aa)
CDC42EP2Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (210 aa)
RASGRF2Ras-specific guanine nucleotide-releasing factor 2. (1239 aa)
RAB39ARas-related protein Rab-39A. (242 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1204 aa)
CDC42EP1Cdc42 effector protein 1. (361 aa)
RGL2Ral guanine nucleotide dissociation stimulator-like 2. (778 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
RAB9BRas-related protein Rab-9B. (201 aa)
DOK3Docking protein 3. (440 aa)
ELMO1Engulfment and cell motility protein 1. (727 aa)
NISCHNischarin. (1500 aa)
RAB39BRas-related protein Rab-39B. (213 aa)
PRKD1Protein kinase D1. (920 aa)
EPS8L3Epidermal growth factor receptor kinase substrate 8-like protein 3. (592 aa)
DBNLDrebrin-like protein. (435 aa)
M91_05661Uncharacterized protein. (108 aa)
RACGAP1Rac GTPase-activating protein 1. (632 aa)
RAB9ARas-related protein Rab-9A. (202 aa)
RAP2ARas-related protein Rap-2a. (179 aa)
PDIA2Protein disulfide isomerase family A member 2. (545 aa)
GDI1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (447 aa)
RALGPS2Ras-specific guanine nucleotide-releasing factor RalGPS2. (583 aa)
PDPNPodoplanin. (168 aa)
RASGRF1Ras-specific guanine nucleotide-releasing factor 1. (1257 aa)
ARHGDIARho GDP-dissociation inhibitor 1. (264 aa)
SHTN1Shootin-1. (568 aa)
CDH13Cadherin 13, H-cadherin. (660 aa)
ENSBMUP00000034400annotation not available (112 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (282 aa)
MAPKAPK5MAP kinase-activated protein kinase 5. (472 aa)
ENSBMUP00000033847annotation not available (224 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1676 aa)
MYO9BMyosin-IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1664 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
ARHGDIGRho GDP-dissociation inhibitor 3. (256 aa)
CSF1Macrophage colony-stimulating factor 1. (545 aa)
RANGRFRan guanine nucleotide release factor. (186 aa)
DOK1Docking protein 1. (483 aa)
SYNJ2BPSynaptojanin-2-binding protein. (145 aa)
RIT1GTP-binding protein Rit1. (218 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
RAB33ARas-related protein Rab-33A. (237 aa)
ENSBMUP00000018435annotation not available (151 aa)
RHOJRho-related GTP-binding protein RhoJ. (274 aa)
LOC102269967Ras-related protein Rap-1b-like. (184 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (731 aa)
ENSBMUP00000014878Protein phosphatase 1 regulatory subunit 21. (52 aa)
TRIM28Transcription intermediary factor 1-beta. (835 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (387 aa)
DOK2Docking protein 2. (413 aa)
ITGA3Integrin alpha-3; Belongs to the integrin alpha chain family. (1065 aa)
KIAA0355DUF4745 domain-containing protein. (1135 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8. (1083 aa)
RAB4BRas-related protein Rab-4B. (213 aa)
ENSBMUP00000014870annotation not available (50 aa)
NF1Neurofibromin. (2848 aa)
RIPOR1Protein FAM65A. (1330 aa)
CDC42EP4CDC42 effector protein 4. (284 aa)
RABGEF1Rab5 GDP/GTP exchange factor. (492 aa)
LOC102284736KLRAQ motif-containing protein 1. (419 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
RAB33BRas-related protein Rab-33B. (229 aa)
KSR1Kinase suppressor of Ras 1. (928 aa)
ENSBMUP00000015288annotation not available (621 aa)
TAX1BP3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
RAB4ARas-related protein Rab-4A. (218 aa)
RASGEF1CRas-GEF domain-containing family member 1C. (236 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
NKIRAS1NF-kappa-B inhibitor-interacting Ras-like protein 1. (192 aa)
KSR2Kinase suppressor of Ras 2. (950 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
RASGEF1ARas-GEF domain-containing family member 1A. (488 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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