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CLN6 CLN6 APOA2 APOA2 G6PD G6PD SQLE SQLE FDX1 FDX1 CYP27A1 CYP27A1 LDLR LDLR ABCA2 ABCA2 NFE2L1 NFE2L1 ENSBMUP00000034039 ENSBMUP00000034039 APP APP GBA2 GBA2 ABCA5 ABCA5 HMGCS1 HMGCS1 SOAT2 SOAT2 MVK MVK MT3 MT3 ANGPTL3 ANGPTL3 HNF1A HNF1A NSDHL NSDHL ARV1 ARV1 APOE APOE ABCG1 ABCG1 LSS LSS LOC102278261 LOC102278261 APOF APOF ABCA1 ABCA1 VLDLR VLDLR SREBF1 SREBF1 LEPR LEPR LOC102280195 LOC102280195 SULT2B1 SULT2B1 CDCP2 CDCP2 CYB5R3 CYB5R3 CYP11A1 CYP11A1 AKR1D1 AKR1D1 INSIG2 INSIG2 TMEM130 TMEM130 SOAT1 SOAT1 CFTR CFTR SMPD1 SMPD1 MVD MVD SCAP SCAP FDPS FDPS GBA GBA HMGCS2 HMGCS2 HSD17B7 HSD17B7 PIP4P1 PIP4P1 HMGCR HMGCR CYP7A1 CYP7A1 LOC102269605 LOC102269605 HDLBP HDLBP ENSBMUP00000015050 ENSBMUP00000015050 PMVK PMVK CLN8 CLN8 DHCR7 DHCR7 SCARB1 SCARB1 SC5D SC5D DHCR24 DHCR24 PON1 PON1 CAT CAT CUBN CUBN FDXR FDXR ENSBMUP00000010625 ENSBMUP00000010625 APOA4 APOA4 APOA5 APOA5 LOC102272939 LOC102272939 LIPE LIPE ENSBMUP00000009757 ENSBMUP00000009757 NPC2 NPC2 ERLIN2 ERLIN2 LBR LBR STAR STAR APOB APOB EBP EBP LRP5L LRP5L ENSBMUP00000006513 ENSBMUP00000006513 CYP46A1 CYP46A1 LIPC LIPC IDI1 IDI1 TM7SF2 TM7SF2 LCAT LCAT CYP51A1 CYP51A1 INSIG1 INSIG1 LEP LEP FDFT1 FDFT1 CH25H CH25H TSKU TSKU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLN6Ceroid-lipofuscinosis neuronal protein 6-like protein. (339 aa)
APOA2Apolipoprotein A-II. (100 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase. (632 aa)
SQLESqualene monooxygenase. (572 aa)
FDX1Adrenodoxin, mitochondrial. (185 aa)
CYP27A1Sterol 26-hydroxylase, mitochondrial. (538 aa)
LDLRLow-density lipoprotein receptor. (844 aa)
ABCA2ATP binding cassette subfamily A member 2. (2264 aa)
NFE2L1Nuclear factor erythroid 2-related factor 1; Belongs to the bZIP family. (774 aa)
ENSBMUP00000034039annotation not available (405 aa)
APPAmyloid beta A4 protein. (652 aa)
GBA2Non-lysosomal glucosylceramidase. (926 aa)
ABCA5ATP-binding cassette, subfamily A (ABC1), member 5. (1596 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
SOAT2O-acyltransferase. (524 aa)
MVKMevalonate kinase. (451 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
ANGPTL3Angiopoietin like 3. (447 aa)
HNF1AHepatocyte nuclear factor 1-alpha. (633 aa)
NSDHLSterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Belongs to the 3-beta-HSD family. (356 aa)
ARV1Protein ARV1. (282 aa)
APOEApolipoprotein E. (326 aa)
ABCG1ATP-binding cassette sub-family G member 1. (677 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (732 aa)
LOC102278261Apolipoprotein F. (254 aa)
APOFApolipoprotein F. (348 aa)
ABCA1ATP-binding cassette sub-family A member 1. (2120 aa)
VLDLRVery low density lipoprotein receptor. (850 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1173 aa)
LEPRLeptin receptor. (1165 aa)
LOC102280195Uncharacterized protein; Belongs to the cytochrome P450 family. (469 aa)
SULT2B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (338 aa)
CDCP2CUB domain-containing protein 2. (406 aa)
CYB5R3NADH-cytochrome b5 reductase 3. (303 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (578 aa)
AKR1D13-oxo-5-beta-steroid 4-dehydrogenase. (326 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (224 aa)
TMEM130Transmembrane protein 130. (410 aa)
SOAT1O-acyltransferase. (567 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1189 aa)
SMPD1Sphingomyelin phosphodiesterase. (625 aa)
MVDDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (400 aa)
SCAPSterol regulatory element-binding protein cleavage-activating protein. (1279 aa)
FDPSFarnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (353 aa)
GBAGlucosylceramidase. (536 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
HSD17B73-keto-steroid reductase. (334 aa)
PIP4P1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (500 aa)
LOC102269605ATP-binding cassette sub-family A member 1-like. (159 aa)
HDLBPVigilin. (1268 aa)
ENSBMUP00000015050annotation not available (117 aa)
PMVKPhosphomevalonate kinase. (192 aa)
CLN8Protein CLN8. (274 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (513 aa)
SC5DLathosterol oxidase; Belongs to the sterol desaturase family. (359 aa)
DHCR2424-dehydrocholesterol reductase. (516 aa)
PON1Serum paraoxonase/arylesterase 1. (355 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
CUBNCubilin. (3613 aa)
FDXRNADPH:adrenodoxin oxidoreductase, mitochondrial. (519 aa)
ENSBMUP00000010625annotation not available (202 aa)
APOA4Apolipoprotein A-IV. (380 aa)
APOA5Apolipoprotein A-V. (368 aa)
LOC102272939Cytochrome P450 11B1, mitochondrial; Belongs to the cytochrome P450 family. (570 aa)
LIPEHormone-sensitive lipase. (799 aa)
ENSBMUP00000009757annotation not available (317 aa)
NPC2Epididymal secretory protein E1. (158 aa)
ERLIN2Erlin-2. (424 aa)
LBRLamin-B receptor. (621 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
APOBApolipoprotein B. (4558 aa)
EBP3-beta-hydroxysteroid-Delta(8), Delta(7)-isomerase. (227 aa)
LRP5LLow-density lipoprotein receptor-related protein 5. (251 aa)
ENSBMUP00000006513annotation not available (256 aa)
CYP46A1Cholesterol 24-hydroxylase; Belongs to the cytochrome P450 family. (403 aa)
LIPCHepatic triacylglycerol lipase. (471 aa)
IDI1Isopentenyl-diphosphate Delta-isomerase 1. (227 aa)
TM7SF2Delta(14)-sterol reductase. (418 aa)
LCATPhosphatidylcholine-sterol acyltransferase. (440 aa)
CYP51A1Lanosterol 14-alpha demethylase; Belongs to the cytochrome P450 family. (510 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (276 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
FDFT1Squalene synthase. (476 aa)
CH25HCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (270 aa)
TSKUTsukushin. (358 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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