(39 nodes) Phosphatidylinositol 3-kinase signaling network (Bos mutus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZFP36L1	Zinc finger protein 36, C3H1 type-like 1. (338 aa)
	NF1	Neurofibromin. (2848 aa)
	IGF1	Insulin-like growth factor I. (194 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
	KBTBD2	Kelch repeat and BTB domain-containing protein 2. (623 aa)
	PRR5L	Proline rich 5 like. (368 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1104 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	C1QBP	Complement component 1 Q subcomponent-binding protein, mitochondrial. (177 aa)
	ARHGAP8	Rho GTPase-activating protein 8. (306 aa)
	PRR5	Proline rich 5. (348 aa)
	RPS6KB1	Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily. (525 aa)
	PIK3C2G	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma. (230 aa)
	EDN1	Endothelin-1. (202 aa)
	PPARD	Peroxisome proliferator-activated receptor delta. (441 aa)
	ERBB2	Erb-b2 receptor tyrosine kinase 2. (1379 aa)
	PIK3CD	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta. (1044 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
	NYAP1	Uncharacterized protein. (607 aa)
	AKT1	RAC serine/threonine-protein kinase. (421 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (538 aa)
	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
	PREX2	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein. (1604 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
	CD28	T-cell-specific surface glycoprotein CD28. (265 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha. (1688 aa)
	LOC102287125	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma; Belongs to the PI3/PI4-kinase family. (585 aa)
	ENSBMUP00000024422	annotation not available (88 aa)
	PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
	LOC102284058	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2. (409 aa)
	ERBB3	Receptor tyrosine-protein kinase erbB-3. (1336 aa)
	SERPINA12	Serpin A12; Belongs to the serpin family. (412 aa)
	PIK3CA	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
	PEAR1	Platelet endothelial aggregation receptor 1. (1040 aa)
	SIRT2	NAD-dependent deacetylase sirtuin-2. (353 aa)
	PLEKHA1	Pleckstrin-like protein domain-containing family A member 1. (404 aa)
	IRS1	Insulin receptor substrate 1. (1237 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (493 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	IGF1	ENSBMUP00000035432	ENSBMUP00000013065	RAC serine/threonine-protein kinase.	Insulin-like growth factor I.	0.604
AKT1	IRS1	ENSBMUP00000035432	ENSBMUP00000017911	RAC serine/threonine-protein kinase.	Insulin receptor substrate 1.	0.680
AKT1	LOC102284058	ENSBMUP00000035432	ENSBMUP00000023668	RAC serine/threonine-protein kinase.	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2.	0.563
AKT1	PIK3CA	ENSBMUP00000035432	ENSBMUP00000022113	RAC serine/threonine-protein kinase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family.	0.974
AKT1	PIK3CB	ENSBMUP00000035432	ENSBMUP00000008705	RAC serine/threonine-protein kinase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	0.962
AKT1	PIK3CD	ENSBMUP00000035432	ENSBMUP00000002194	RAC serine/threonine-protein kinase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta.	0.532
AKT1	PIK3CG	ENSBMUP00000035432	ENSBMUP00000010412	RAC serine/threonine-protein kinase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family.	0.961
AKT1	PIK3R1	ENSBMUP00000035432	ENSBMUP00000012969	RAC serine/threonine-protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.963
AKT1	PIK3R2	ENSBMUP00000035432	ENSBMUP00000034582	RAC serine/threonine-protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.953
AKT1	PTEN	ENSBMUP00000035432	ENSBMUP00000008299	RAC serine/threonine-protein kinase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.766
AKT1	RPS6KB1	ENSBMUP00000035432	ENSBMUP00000006561	RAC serine/threonine-protein kinase.	Ribosomal protein S6 kinase beta-1; Belongs to the protein kinase superfamily.	0.958
AKT1	ZFP36L1	ENSBMUP00000035432	ENSBMUP00000016850	RAC serine/threonine-protein kinase.	Zinc finger protein 36, C3H1 type-like 1.	0.440
ARHGAP8	PRR5L	ENSBMUP00000006863	ENSBMUP00000012207	Rho GTPase-activating protein 8.	Proline rich 5 like.	0.437
CD28	PIK3CA	ENSBMUP00000025183	ENSBMUP00000022113	T-cell-specific surface glycoprotein CD28.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family.	0.943
CD28	PIK3CB	ENSBMUP00000025183	ENSBMUP00000008705	T-cell-specific surface glycoprotein CD28.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	0.926
CD28	PIK3R1	ENSBMUP00000025183	ENSBMUP00000012969	T-cell-specific surface glycoprotein CD28.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.984
CD28	PIK3R2	ENSBMUP00000025183	ENSBMUP00000034582	T-cell-specific surface glycoprotein CD28.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.965
EDN1	IGF1	ENSBMUP00000003300	ENSBMUP00000013065	Endothelin-1.	Insulin-like growth factor I.	0.467
ENSBMUP00000024422	ERBB2	ENSBMUP00000024422	ENSBMUP00000002936	annotation not available	Erb-b2 receptor tyrosine kinase 2.	0.887
ENSBMUP00000024422	PIK3CA	ENSBMUP00000024422	ENSBMUP00000022113	annotation not available	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family.	0.685