(14 nodes) Telomere capping network (Bos mutus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TINF2	TERF1-interacting nuclear factor 2. (463 aa)
	TERF2	Telomeric repeat-binding factor 2. (540 aa)
	STN1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (371 aa)
	DCLRE1C	Protein artemis. (689 aa)
	TERF2IP	Telomeric repeat-binding factor 2-interacting protein 1. (399 aa)
	TERF1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (438 aa)
	POT1	Protection of telomeres protein 1. (473 aa)
	DCLRE1A	DNA cross-link repair 1A protein. (1051 aa)
	RAD50	DNA repair protein RAD50. (1311 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic polypeptide. (3851 aa)
	NBN	Nibrin. (754 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
	ACD	Adrenocortical dysplasia protein-like protein. (455 aa)
	DCLRE1B	5' exonuclease Apollo. (542 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	POT1	ENSBMUP00000004402	ENSBMUP00000022570	Adrenocortical dysplasia protein-like protein.	Protection of telomeres protein 1.	0.997
ACD	STN1	ENSBMUP00000004402	ENSBMUP00000000841	Adrenocortical dysplasia protein-like protein.	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	0.780
ACD	TERF1	ENSBMUP00000004402	ENSBMUP00000025319	Adrenocortical dysplasia protein-like protein.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.944
ACD	TERF2	ENSBMUP00000004402	ENSBMUP00000001761	Adrenocortical dysplasia protein-like protein.	Telomeric repeat-binding factor 2.	0.980
ACD	TERF2IP	ENSBMUP00000004402	ENSBMUP00000029199	Adrenocortical dysplasia protein-like protein.	Telomeric repeat-binding factor 2-interacting protein 1.	0.983
ACD	TINF2	ENSBMUP00000004402	ENSBMUP00000033472	Adrenocortical dysplasia protein-like protein.	TERF1-interacting nuclear factor 2.	0.997
DCLRE1A	DCLRE1B	ENSBMUP00000021404	ENSBMUP00000003852	DNA cross-link repair 1A protein.	5' exonuclease Apollo.	0.443
DCLRE1A	MRE11	ENSBMUP00000021404	ENSBMUP00000005750	DNA cross-link repair 1A protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.637
DCLRE1A	NBN	ENSBMUP00000021404	ENSBMUP00000013714	DNA cross-link repair 1A protein.	Nibrin.	0.548
DCLRE1A	PRKDC	ENSBMUP00000021404	ENSBMUP00000014766	DNA cross-link repair 1A protein.	Protein kinase, DNA-activated, catalytic polypeptide.	0.533
DCLRE1A	RAD50	ENSBMUP00000021404	ENSBMUP00000019216	DNA cross-link repair 1A protein.	DNA repair protein RAD50.	0.498
DCLRE1A	TERF2	ENSBMUP00000021404	ENSBMUP00000001761	DNA cross-link repair 1A protein.	Telomeric repeat-binding factor 2.	0.706
DCLRE1A	TERF2IP	ENSBMUP00000021404	ENSBMUP00000029199	DNA cross-link repair 1A protein.	Telomeric repeat-binding factor 2-interacting protein 1.	0.549
DCLRE1B	DCLRE1A	ENSBMUP00000003852	ENSBMUP00000021404	5' exonuclease Apollo.	DNA cross-link repair 1A protein.	0.443
DCLRE1B	MRE11	ENSBMUP00000003852	ENSBMUP00000005750	5' exonuclease Apollo.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.625
DCLRE1B	NBN	ENSBMUP00000003852	ENSBMUP00000013714	5' exonuclease Apollo.	Nibrin.	0.548
DCLRE1B	POT1	ENSBMUP00000003852	ENSBMUP00000022570	5' exonuclease Apollo.	Protection of telomeres protein 1.	0.458
DCLRE1B	PRKDC	ENSBMUP00000003852	ENSBMUP00000014766	5' exonuclease Apollo.	Protein kinase, DNA-activated, catalytic polypeptide.	0.550
DCLRE1B	RAD50	ENSBMUP00000003852	ENSBMUP00000019216	5' exonuclease Apollo.	DNA repair protein RAD50.	0.498
DCLRE1B	TERF1	ENSBMUP00000003852	ENSBMUP00000025319	5' exonuclease Apollo.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.503