(74 nodes) Regulation of nervous system process network (Bos mutus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSBMUP00000004838	annotation not available (75 aa)
	M91_09525	Spexin. (102 aa)
	TNR	Tenascin-R. (1229 aa)
	CHRNB4	Neuronal acetylcholine receptor subunit beta-4. (462 aa)
	SLC8A2	Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (889 aa)
	TNFRSF21	Tumor necrosis factor receptor superfamily member 21. (634 aa)
	BEGAIN	Brain-enriched guanylate kinase-associated protein. (657 aa)
	CST7	Cystatin-F. (145 aa)
	PAWR	PRKC apoptosis WT1 regulator protein. (242 aa)
	DLGAP3	Disks large-associated protein 3. (915 aa)
	ACPP	Prostatic acid phosphatase; Belongs to the histidine acid phosphatase family. (419 aa)
	TMEM108	Transmembrane protein 108. (583 aa)
	MTMR2	Myotubularin-related protein 2. (643 aa)
	MAG	Myelin-associated glycoprotein. (626 aa)
	NLGN1	Neuroligin-1. (823 aa)
	NLGN2	Neuroligin-2. (763 aa)
	ENSBMUP00000008642	annotation not available (81 aa)
	ATPSCKMT	Protein FAM173B. (233 aa)
	STX1A	Syntaxin 1A. (345 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	RELN	Reelin. (3347 aa)
	DLGAP2	Disks large-associated protein 2. (1054 aa)
	F2R	Proteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (422 aa)
	GLRA1	Glycine receptor subunit alpha-1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
	TMEM25	Transmembrane protein 25. (427 aa)
	TENM4	Teneurin-4. (2707 aa)
	EGR2	Early growth response protein 2. (450 aa)
	LOC102287625	C-C motif chemokine. (125 aa)
	GBA	Glucosylceramidase. (536 aa)
	TPPP	Tubulin polymerization-promoting protein. (208 aa)
	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B. (438 aa)
	CELF4	CUGBP Elav-like family member 4. (486 aa)
	GRM1	Glutamate metabotropic receptor 1. (1092 aa)
	NPTX2	Neuronal pentraxin-2. (431 aa)
	TMEM130	Transmembrane protein 130. (410 aa)
	MGLL	Monoglyceride lipase. (363 aa)
	HOMER3	Homer protein-like protein 3. (358 aa)
	LRRK2	Leucine-rich repeat serine/threonine-protein kinase 2. (2527 aa)
	FFAR3	Free fatty acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (365 aa)
	HCRT	Orexin. (131 aa)
	FABP5	Fatty acid-binding protein, epidermal; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
	GRIN2D	Glutamate [NMDA] receptor subunit epsilon-4. (935 aa)
	ZNF488	Zinc finger protein 488. (234 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains protein 3. (1391 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	SCN11A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1782 aa)
	FIG4	FIG4 phosphoinositide 5-phosphatase. (885 aa)
	HOMER1	Homer protein-like protein 1. (374 aa)
	NPTX1	Neuronal pentraxin 1. (410 aa)
	ADRB2	Beta-2 adrenergic receptor. (418 aa)
	TMEM100	Transmembrane protein 100. (134 aa)
	DMPK	Myotonin-protein kinase. (593 aa)
	KLK8	Kallikrein-8; Belongs to the peptidase S1 family. (259 aa)
	FMR1	Fragile X mental retardation 1 protein. (632 aa)
	SHANK1	SH3 and multiple ankyrin repeat domains protein 1. (1402 aa)
	S1PR2	Sphingosine 1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	CUX2	Homeobox protein cut-like 2. (1502 aa)
	GPR171	Putative G-protein coupled receptor 171; Belongs to the G-protein coupled receptor 1 family. (319 aa)
	RNF10	Ring finger protein 10. (807 aa)
	WASF3	Wiskott-Aldrich syndrome protein family member 3. (499 aa)
	CARTPT	Cocaine-and amphetamine-regulated transcript protein. (116 aa)
	VIP	VIP peptide. (170 aa)
	CBLN1	Cerebellin-1. (193 aa)
	APP	Amyloid beta A4 protein. (652 aa)
	STX1B	Syntaxin-1B; Belongs to the syntaxin family. (260 aa)
	CACNG4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (266 aa)
	CTSC	Dipeptidyl peptidase 1; Belongs to the peptidase C1 family. (463 aa)
	ZFHX2	Zinc finger homeobox protein 2. (2518 aa)
	NPTXR	Neuronal pentraxin receptor. (316 aa)
	MYRF	Myelin regulatory factor. (1135 aa)
	DLGAP1	Discs, large-associated protein 1. (971 aa)
	DLGAP4	DLG associated protein 4. (978 aa)
	AKAP9	A-kinase anchoring protein 9. (3895 aa)
	NETO1	Neuropilin and tolloid-like protein 1. (533 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRB2	TMEM100	ENSBMUP00000023893	ENSBMUP00000024966	Beta-2 adrenergic receptor.	Transmembrane protein 100.	0.530
APP	FMR1	ENSBMUP00000033831	ENSBMUP00000026087	Amyloid beta A4 protein.	Fragile X mental retardation 1 protein.	0.500
APP	GRM1	ENSBMUP00000033831	ENSBMUP00000018687	Amyloid beta A4 protein.	Glutamate metabotropic receptor 1.	0.416
APP	KLK8	ENSBMUP00000033831	ENSBMUP00000025996	Amyloid beta A4 protein.	Kallikrein-8; Belongs to the peptidase S1 family.	0.563
APP	RELN	ENSBMUP00000033831	ENSBMUP00000013404	Amyloid beta A4 protein.	Reelin.	0.418
APP	TNFRSF21	ENSBMUP00000033831	ENSBMUP00000005293	Amyloid beta A4 protein.	Tumor necrosis factor receptor superfamily member 21.	0.830
BEGAIN	DLGAP2	ENSBMUP00000006095	ENSBMUP00000013886	Brain-enriched guanylate kinase-associated protein.	Disks large-associated protein 2.	0.414
BEGAIN	DLGAP3	ENSBMUP00000006095	ENSBMUP00000006909	Brain-enriched guanylate kinase-associated protein.	Disks large-associated protein 3.	0.621
BEGAIN	DLGAP4	ENSBMUP00000006095	ENSBMUP00000001666	Brain-enriched guanylate kinase-associated protein.	DLG associated protein 4.	0.599
CBLN1	GRM1	ENSBMUP00000033053	ENSBMUP00000018687	Cerebellin-1.	Glutamate metabotropic receptor 1.	0.447
CBLN1	NLGN1	ENSBMUP00000033053	ENSBMUP00000008134	Cerebellin-1.	Neuroligin-1.	0.402
CST7	CTSC	ENSBMUP00000006812	ENSBMUP00000035423	Cystatin-F.	Dipeptidyl peptidase 1; Belongs to the peptidase C1 family.	0.530
CTSC	CST7	ENSBMUP00000035423	ENSBMUP00000006812	Dipeptidyl peptidase 1; Belongs to the peptidase C1 family.	Cystatin-F.	0.530
DLGAP1	DLGAP3	ENSBMUP00000001575	ENSBMUP00000006909	Discs, large-associated protein 1.	Disks large-associated protein 3.	0.490
DLGAP1	HOMER1	ENSBMUP00000001575	ENSBMUP00000023290	Discs, large-associated protein 1.	Homer protein-like protein 1.	0.539
DLGAP1	HOMER3	ENSBMUP00000001575	ENSBMUP00000020028	Discs, large-associated protein 1.	Homer protein-like protein 3.	0.464
DLGAP1	NLGN1	ENSBMUP00000001575	ENSBMUP00000008134	Discs, large-associated protein 1.	Neuroligin-1.	0.631
DLGAP1	NLGN2	ENSBMUP00000001575	ENSBMUP00000008427	Discs, large-associated protein 1.	Neuroligin-2.	0.522
DLGAP1	SHANK1	ENSBMUP00000001575	ENSBMUP00000026650	Discs, large-associated protein 1.	SH3 and multiple ankyrin repeat domains protein 1.	0.890
DLGAP1	SHANK3	ENSBMUP00000001575	ENSBMUP00000022440	Discs, large-associated protein 1.	SH3 and multiple ankyrin repeat domains protein 3.	0.844