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LARS1 LARS1 TTI1 TTI1 C9orf72 C9orf72 SH3BP4 SH3BP4 LEP LEP M91_06276 M91_06276 LAMTOR5 LAMTOR5 PIH1D1 PIH1D1 MTM1 MTM1 GPR137C GPR137C STK11 STK11 KPTN KPTN GPAT3 GPAT3 KLHL22 KLHL22 ENSBMUP00000007163 ENSBMUP00000007163 MIOS MIOS LOC102271788 LOC102271788 SEC13 SEC13 ENSBMUP00000009162 ENSBMUP00000009162 GSK3A GSK3A UBR1 UBR1 M91_02843 M91_02843 RRAGB RRAGB LAMTOR3 LAMTOR3 PRKAA2 PRKAA2 M91_13835 M91_13835 WAC WAC RELN RELN ZMPSTE24 ZMPSTE24 TNFAIP8L1 TNFAIP8L1 ROS1 ROS1 SEH1L SEH1L CASTOR2 CASTOR2 CTNS CTNS PIP4P1 PIP4P1 USP9X USP9X ENSBMUP00000016704 ENSBMUP00000016704 GOLPH3 GOLPH3 GBA GBA PDCD6 PDCD6 UBR2 UBR2 LAMTOR2 LAMTOR2 GPR137 GPR137 TMEM130 TMEM130 RICTOR RICTOR RRAGA RRAGA SESN3 SESN3 AKT3 AKT3 FNIP1 FNIP1 SMCR8 SMCR8 MLST8 MLST8 CLEC16A CLEC16A FLCN FLCN TBCK TBCK SESN1 SESN1 SZT2 SZT2 DDIT4 DDIT4 TSC2 TSC2 SESN2 SESN2 LAMTOR1 LAMTOR1 RPTOR RPTOR GPR137B GPR137B MINAR1 MINAR1 PRKAA1 PRKAA1 DEPTOR DEPTOR ARAF ARAF CASTOR1 CASTOR1 MAPKAPK5 MAPKAPK5 DYRK3 DYRK3 TBC1D7 TBC1D7 HIF1A HIF1A TMEM127 TMEM127 C12orf66 C12orf66 DGKQ DGKQ NPRL3 NPRL3 BMT2 BMT2 TREM2 TREM2 WDR24 WDR24 LAMTOR4 LAMTOR4 DEPDC5 DEPDC5 GAS6 GAS6 SLC38A9 SLC38A9 SIRT1 SIRT1 PKHD1 PKHD1 HDAC3 HDAC3 WDR59 WDR59 TELO2 TELO2 M91_08538 M91_08538 FBXO9 FBXO9 ENDOG ENDOG RRAGD RRAGD NPRL2 NPRL2 NCKAP1L NCKAP1L GNA12 GNA12 FAM83D FAM83D ITFG2 ITFG2 TSC1 TSC1 AKT1S1 AKT1S1 RRAGC RRAGC OTUD5 OTUD5 M91_09858 M91_09858
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LARS1Leucyl-tRNA synthetase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (1176 aa)
TTI1TEL2-interacting protein 1-like protein. (1092 aa)
C9orf72Uncharacterized protein. (481 aa)
SH3BP4SH3 domain-binding protein 4. (963 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
M91_06276Uncharacterized protein. (82 aa)
LAMTOR5Hepatitis B virus X-interacting protein-like protein. (91 aa)
PIH1D1PIH1 domain-containing protein 1. (290 aa)
MTM1Myotubularin. (603 aa)
GPR137CIntegral membrane protein GPR137C. (428 aa)
STK11Serine/threonine-protein kinase 11; Belongs to the protein kinase superfamily. (438 aa)
KPTNKaptin. (500 aa)
GPAT3Glycerol-3-phosphate acyltransferase 3. (438 aa)
KLHL22Kelch-like protein 22. (634 aa)
ENSBMUP00000007163annotation not available (83 aa)
MIOSWD repeat-containing protein mio. (875 aa)
LOC102271788Somatotropin. (216 aa)
SEC13Protein SEC13-like protein; Belongs to the WD repeat SEC13 family. (325 aa)
ENSBMUP00000009162annotation not available (89 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
UBR1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1615 aa)
M91_02843GTP-binding protein Rheb. (79 aa)
RRAGBRas-related GTP-binding protein B-like. (371 aa)
LAMTOR3Mitogen-activated protein kinase scaffold protein 1. (124 aa)
PRKAA2Non-specific serine/threonine protein kinase. (533 aa)
M91_13835Serine-protein kinase ATM. (319 aa)
WACWW domain-containing adapter protein with coiled-coil. (601 aa)
RELNReelin. (3347 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
TNFAIP8L1Tumor necrosis factor alpha-induced protein 8-like protein 1. (168 aa)
ROS1Tyrosine-protein kinase receptor. (2345 aa)
SEH1LNucleoporin SEH1; Belongs to the WD repeat SEC13 family. (356 aa)
CASTOR2GATS-like protein 2. (378 aa)
CTNSCystinosin. (399 aa)
PIP4P1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
USP9XPutative ubiquitin carboxyl-terminal hydrolase FAF-X; Belongs to the peptidase C19 family. (2554 aa)
ENSBMUP00000016704annotation not available (100 aa)
GOLPH3Golgi phosphoprotein 3. (234 aa)
GBAGlucosylceramidase. (536 aa)
PDCD6Programmed cell death protein 6. (189 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1756 aa)
LAMTOR2Mitogen-activated protein-binding protein-interacting protein. (125 aa)
GPR137Integral membrane protein GPR137. (395 aa)
TMEM130Transmembrane protein 130. (410 aa)
RICTORRapamycin-insensitive companion of mTOR. (1737 aa)
RRAGARas-related GTP-binding protein A. (313 aa)
SESN3Sestrin-3. (492 aa)
AKT3RAC-gamma serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (441 aa)
FNIP1Folliculin-interacting protein 1. (1163 aa)
SMCR8Smith-Magenis syndrome chromosomal region candidate 8 protein. (934 aa)
MLST8Target of rapamycin complex subunit LST8. (326 aa)
CLEC16AProtein CLEC16A. (1050 aa)
FLCNFolliculin. (579 aa)
TBCKTBC domain-containing protein kinase-like protein. (893 aa)
SESN1Sestrin-1. (552 aa)
SZT2Protein SZT2. (3428 aa)
DDIT4DNA damage-inducible transcript 4 protein. (229 aa)
TSC2Tuberous sclerosis 2. (1812 aa)
SESN2Sestrin-2. (471 aa)
LAMTOR1Uncharacterized protein. (161 aa)
RPTORRegulatory-associated protein of mTOR. (1335 aa)
GPR137BIntegral membrane protein GPR137B. (265 aa)
MINAR1UPF0258 protein KIAA1024. (917 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
DEPTORDEP domain-containing mTOR-interacting protein. (447 aa)
ARAFSerine/threonine-protein kinase A-Raf. (611 aa)
CASTOR1GATS-like protein 3. (369 aa)
MAPKAPK5MAP kinase-activated protein kinase 5. (472 aa)
DYRK3Dual specificity tyrosine-phosphorylation-regulated kinase 3. (582 aa)
TBC1D7TBC1 domain family member 7. (292 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
TMEM127Transmembrane protein 127. (238 aa)
C12orf66Chromosome unknown open reading frame, human C12orf66. (443 aa)
DGKQDiacylglycerol kinase. (844 aa)
NPRL3Nitrogen permease regulator 3-like protein. (569 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (244 aa)
WDR24WD repeat-containing protein 24. (790 aa)
LAMTOR4Uncharacterized protein. (128 aa)
DEPDC5DEP domain-containing protein 5. (1598 aa)
GAS6Growth arrest specific 6. (614 aa)
SLC38A9Solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9. (560 aa)
SIRT1NAD-dependent deacetylase sirtuin-1. (454 aa)
PKHD1Polycystic kidney and hepatic disease 1 (autosomal recessive). (3599 aa)
HDAC3Histone deacetylase 3. (428 aa)
WDR59WD repeat-containing protein 59. (973 aa)
TELO2Telomere length regulation protein TEL2-like protein. (822 aa)
M91_08538Uncharacterized protein. (91 aa)
FBXO9F-box only protein 9. (436 aa)
ENDOGEndonuclease G. (292 aa)
RRAGDRas-related GTP-binding protein D. (397 aa)
NPRL2Nitrogen permease regulator 2-like protein. (380 aa)
NCKAP1LNck-associated protein 1-like protein. (1128 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (291 aa)
FAM83DProtein FAM83D. (417 aa)
ITFG2Integrin-alpha FG-GAP repeat-containing protein 2. (444 aa)
TSC1Hamartin. (1159 aa)
AKT1S1Proline-rich AKT1 substrate 1. (349 aa)
RRAGCRas-related GTP-binding protein C. (389 aa)
OTUD5OTU domain-containing protein 5. (566 aa)
M91_09858Uncharacterized protein. (91 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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