115 items (Bos mutus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL27RA	Interleukin-27 receptor subunit alpha. (639 aa)
	MYD88	Myeloid differentiation primary response protein MyD88. (296 aa)
	DDX58	Putative ATP-dependent RNA helicase DDX58. (942 aa)
	IFIH1	Interferon-induced helicase C domain-containing protein 1. (1019 aa)
	HGF	Hepatocyte growth factor; Belongs to the peptidase S1 family. (705 aa)
	RAB7B	Ras-related protein Rab-7b. (197 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (479 aa)
	NLRC3	Protein NLRC3. (1043 aa)
	SPHK2	Sphingosine kinase 2. (653 aa)
	ZBTB20	Zinc finger and BTB domain-containing protein 20. (788 aa)
	M91_01211	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa)
	BANK1	B-cell scaffold protein with ankyrin repeats. (754 aa)
	TLR8	Toll-like receptor 8; Belongs to the Toll-like receptor family. (1033 aa)
	TLR7	Toll-like receptor 7. (1054 aa)
	TMEM130	Transmembrane protein 130. (410 aa)
	TICAM2	Toll like receptor adaptor molecule 2. (121 aa)
	MBP	Myelin basic protein. (329 aa)
	ADORA2B	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (324 aa)
	IL1RAP	Interleukin-1 receptor accessory protein. (685 aa)
	ARHGEF2	Rho guanine nucleotide exchange factor 2. (1275 aa)
	NLRP12	NACHT, LRR and PYD domains-containing protein 12. (1047 aa)
	AIF1	Allograft inflammatory factor 1. (147 aa)
	POU2AF1	POU domain class 2-associating factor 1. (284 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	SYT11	Synaptotagmin-11. (461 aa)
	SLAMF1	Signaling lymphocytic activation molecule. (348 aa)
	CD84	SLAM family member 5. (351 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	CYBA	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (191 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	CD74	HLA class II histocompatibility antigen gamma chain. (268 aa)
	GBA	Glucosylceramidase. (536 aa)
	ENSBMUP00000015897	annotation not available (247 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (580 aa)
	IL17RC	Interleukin 17 receptor C. (749 aa)
	F2R	Proteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (422 aa)
	F2RL1	Proteinase-activated receptor 2. (388 aa)
	SETD4	SET domain containing 4. (440 aa)
	LOC102265225	Hepatitis A virus cellular receptor 2. (204 aa)
	M91_07172	Uncharacterized protein. (73 aa)
	IL6R	Interleukin-6 receptor subunit alpha. (399 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2. (539 aa)
	FOXJ1	Forkhead box protein J1. (421 aa)
	NLRX1	NLR family member X1. (973 aa)
	SYK	Non-specific protein-tyrosine kinase. (629 aa)
	HSPD1	60 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (573 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3. (780 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type 6. (597 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (801 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)
	TLR2	Toll-like receptor 2; Belongs to the Toll-like receptor family. (800 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type 11. (593 aa)
	HAVCR2	Hepatitis A virus cellular receptor 2. (242 aa)
	IL17RA	Interleukin-17 receptor A. (773 aa)
	IL36RN	Interleukin-1. (155 aa)
	LOC102288248	Interleukin-1. (208 aa)
	IL37	Interleukin-1. (216 aa)
	TLR9	Toll like receptor 9. (1006 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
	DHX9	ATP-dependent RNA helicase A. (1287 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD. (195 aa)
	MAPKAPK2	MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	IL10	Interleukin-10. (179 aa)
	APP	Amyloid beta A4 protein. (652 aa)
	INPP5D	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1. (1203 aa)
	ARID5A	AT-rich interactive domain-containing protein 5A. (630 aa)
	M91_14501	CARD_2 domain-containing protein. (75 aa)
	SELENOK	Selenoprotein K. (94 aa)
	NR1H4	Bile acid receptor. (486 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (244 aa)
	GAS6	Growth arrest specific 6. (614 aa)
	AGER	Advanced glycosylation end-product specific receptor. (416 aa)
	POU2F2	POU domain protein. (586 aa)
	NOD1	Nucleotide-binding oligomerization domain-containing protein 1. (954 aa)
	NMB	Neuromedin-B. (121 aa)
	GHRL	Appetite-regulating hormone. (116 aa)
	C1QTNF3	Complement C1q tumor necrosis factor-related protein 3. (246 aa)
	GHSR	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	MMP8	Neutrophil collagenase. (470 aa)
	ISL1	Insulin enhancer protein ISL-1. (349 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
	ZC3H12A	Ribonuclease ZC3H12A. (583 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	ARRB2	Arrestin beta 2. (401 aa)
	TNFSF4	Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (181 aa)
	C5AR2	C5a anaphylatoxin chemotactic receptor C5L2. (337 aa)
	CARD9	Caspase recruitment domain-containing protein 9. (539 aa)
	FOXP3	Forkhead box P3. (454 aa)
	ARRB1	Beta-arrestin-1. (429 aa)
	RABGEF1	Rab5 GDP/GTP exchange factor. (492 aa)
	PTPN22	Tyrosine-protein phosphatase non-receptor type 12/18/22. (801 aa)
	CD47	Leukocyte surface antigen CD47. (342 aa)
	IL1RL2	Interleukin-1 receptor-like 2. (523 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	EREG	Proepiregulin. (169 aa)
	TRPV4	Transient receptor putative cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
	HYAL2	Hyaluronidase. (473 aa)
	IL6	Interleukin-6. (254 aa)
	LOC102278203	Uncharacterized protein. (166 aa)
	IL17A	Interleukin-17A. (153 aa)
	IL17F	Interleukin-17F. (170 aa)
	MAVS	Mitochondrial antiviral-signaling protein. (510 aa)
	CLEC7A	C-type lectin domain family 7 member A. (247 aa)
	AKIRIN2	Akirin-2. (161 aa)
	NCKAP1L	Nck-associated protein 1-like protein. (1128 aa)
	PLCG2	Phosphoinositide phospholipase C. (1240 aa)
	NMBR	Neuromedin-B receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
	TMEM106A	Transmembrane protein 106A. (261 aa)
	BPI	Bactericidal permeability-increasing protein. (484 aa)
	LBP	Lipopolysaccharide-binding protein. (481 aa)
	LOC102265936	Uncharacterized protein. (158 aa)
	AFAP1L2	Actin filament-associated protein 1-like 2. (789 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	APP	ENSBMUP00000031592	ENSBMUP00000033831	Advanced glycosylation end-product specific receptor.	Amyloid beta A4 protein.	0.622
AGER	SYK	ENSBMUP00000031592	ENSBMUP00000013152	Advanced glycosylation end-product specific receptor.	Non-specific protein-tyrosine kinase.	0.491
AIF1	IL1B	ENSBMUP00000018266	ENSBMUP00000010285	Allograft inflammatory factor 1.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.424
AIF1	PYCARD	ENSBMUP00000018266	ENSBMUP00000034031	Allograft inflammatory factor 1.	Apoptosis-associated speck-like protein containing a CARD.	0.516
APP	AGER	ENSBMUP00000033831	ENSBMUP00000031592	Amyloid beta A4 protein.	Advanced glycosylation end-product specific receptor.	0.622
APP	CD74	ENSBMUP00000033831	ENSBMUP00000017203	Amyloid beta A4 protein.	HLA class II histocompatibility antigen gamma chain.	0.447
APP	GHSR	ENSBMUP00000033831	ENSBMUP00000007769	Amyloid beta A4 protein.	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.522
APP	HSPD1	ENSBMUP00000033831	ENSBMUP00000013078	Amyloid beta A4 protein.	60 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family.	0.401
APP	IFNG	ENSBMUP00000033831	ENSBMUP00000015309	Amyloid beta A4 protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.439
APP	IL1B	ENSBMUP00000033831	ENSBMUP00000010285	Amyloid beta A4 protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.526
APP	IL6	ENSBMUP00000033831	ENSBMUP00000028958	Amyloid beta A4 protein.	Interleukin-6.	0.651
APP	MBP	ENSBMUP00000033831	ENSBMUP00000019152	Amyloid beta A4 protein.	Myelin basic protein.	0.405
APP	SYT11	ENSBMUP00000033831	ENSBMUP00000018060	Amyloid beta A4 protein.	Synaptotagmin-11.	0.541
APP	TLR4	ENSBMUP00000033831	ENSBMUP00000012440	Amyloid beta A4 protein.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.527
APP	TNF	ENSBMUP00000033831	ENSBMUP00000018087	Amyloid beta A4 protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.553
APP	TREM2	ENSBMUP00000033831	ENSBMUP00000032471	Amyloid beta A4 protein.	Triggering receptor expressed on myeloid cells 2.	0.563
ARID5A	TNFAIP3	ENSBMUP00000033539	ENSBMUP00000012821	AT-rich interactive domain-containing protein 5A.	Tumor necrosis factor alpha-induced protein 3.	0.417
ARID5A	ZC3H12A	ENSBMUP00000033539	ENSBMUP00000006746	AT-rich interactive domain-containing protein 5A.	Ribonuclease ZC3H12A.	0.404
ARRB1	ARRB2	ENSBMUP00000004697	ENSBMUP00000006262	Beta-arrestin-1.	Arrestin beta 2.	0.937
ARRB1	F2R	ENSBMUP00000004697	ENSBMUP00000014691	Beta-arrestin-1.	Proteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.927