(10 nodes) Histone H2B ubiquitination network (Bos mutus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	WAC	WW domain-containing adapter protein with coiled-coil. (601 aa)
	CTR9	RNA polymerase-associated protein CTR9-like protein. (1173 aa)
	DTX3L	E3 ubiquitin-protein ligase DTX3L. (226 aa)
	PAF1	RNA polymerase II-associated factor 1-like protein. (532 aa)
	RNF8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa)
	RNF20	E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
	CDC73	Parafibromin. (531 aa)
	RNF40	E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1001 aa)
	UBE2E1	Ubiquitin-conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (245 aa)
	LEO1	RNA polymerase-associated protein LEO1. (668 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC73	CTR9	ENSBMUP00000028057	ENSBMUP00000000660	Parafibromin.	RNA polymerase-associated protein CTR9-like protein.	0.999
CDC73	LEO1	ENSBMUP00000028057	ENSBMUP00000013364	Parafibromin.	RNA polymerase-associated protein LEO1.	0.999
CDC73	PAF1	ENSBMUP00000028057	ENSBMUP00000020052	Parafibromin.	RNA polymerase II-associated factor 1-like protein.	0.998
CDC73	RNF20	ENSBMUP00000028057	ENSBMUP00000024635	Parafibromin.	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	0.784
CDC73	RNF40	ENSBMUP00000028057	ENSBMUP00000028808	Parafibromin.	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	0.756
CDC73	WAC	ENSBMUP00000028057	ENSBMUP00000013143	Parafibromin.	WW domain-containing adapter protein with coiled-coil.	0.597
CTR9	CDC73	ENSBMUP00000000660	ENSBMUP00000028057	RNA polymerase-associated protein CTR9-like protein.	Parafibromin.	0.999
CTR9	LEO1	ENSBMUP00000000660	ENSBMUP00000013364	RNA polymerase-associated protein CTR9-like protein.	RNA polymerase-associated protein LEO1.	0.999
CTR9	PAF1	ENSBMUP00000000660	ENSBMUP00000020052	RNA polymerase-associated protein CTR9-like protein.	RNA polymerase II-associated factor 1-like protein.	0.998
CTR9	RNF20	ENSBMUP00000000660	ENSBMUP00000024635	RNA polymerase-associated protein CTR9-like protein.	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	0.715
CTR9	RNF40	ENSBMUP00000000660	ENSBMUP00000028808	RNA polymerase-associated protein CTR9-like protein.	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	0.698
CTR9	WAC	ENSBMUP00000000660	ENSBMUP00000013143	RNA polymerase-associated protein CTR9-like protein.	WW domain-containing adapter protein with coiled-coil.	0.586
LEO1	CDC73	ENSBMUP00000013364	ENSBMUP00000028057	RNA polymerase-associated protein LEO1.	Parafibromin.	0.999
LEO1	CTR9	ENSBMUP00000013364	ENSBMUP00000000660	RNA polymerase-associated protein LEO1.	RNA polymerase-associated protein CTR9-like protein.	0.999
LEO1	PAF1	ENSBMUP00000013364	ENSBMUP00000020052	RNA polymerase-associated protein LEO1.	RNA polymerase II-associated factor 1-like protein.	0.999
LEO1	RNF20	ENSBMUP00000013364	ENSBMUP00000024635	RNA polymerase-associated protein LEO1.	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	0.873
LEO1	RNF40	ENSBMUP00000013364	ENSBMUP00000028808	RNA polymerase-associated protein LEO1.	E3 ubiquitin protein ligase; Belongs to the BRE1 family.	0.868
LEO1	WAC	ENSBMUP00000013364	ENSBMUP00000013143	RNA polymerase-associated protein LEO1.	WW domain-containing adapter protein with coiled-coil.	0.740
PAF1	CDC73	ENSBMUP00000020052	ENSBMUP00000028057	RNA polymerase II-associated factor 1-like protein.	Parafibromin.	0.998
PAF1	CTR9	ENSBMUP00000020052	ENSBMUP00000000660	RNA polymerase II-associated factor 1-like protein.	RNA polymerase-associated protein CTR9-like protein.	0.998