STRINGSTRING
FOXA2 FOXA2 GCM2 GCM2 NKX2-1 NKX2-1 MAPK1 MAPK1 HOXA3 HOXA3 HOXA5 HOXA5 EDN1 EDN1 FGF8 FGF8 PROP1 PROP1 HNF4A HNF4A PAX4 PAX4 EDNRA EDNRA MAPK3 MAPK3 DLL1 DLL1 GLI1 GLI1 ENSBMUP00000034194 ENSBMUP00000034194 ARMC5 ARMC5 SIX1 SIX1 CRHR1 CRHR1 CDH2 CDH2 ONECUT1 ONECUT1 SMO SMO PDX1 PDX1 DUOX2 DUOX2 FGF10 FGF10 ONECUT2 ONECUT2 ENSBMUP00000029231 ENSBMUP00000029231 RFX6 RFX6 GIPR GIPR WNT11 WNT11 PITX1 PITX1 HOXB3 HOXB3 GHRH GHRH GIP GIP GATA3 GATA3 BMP5 BMP5 NEUROD1 NEUROD1 NR5A1 NR5A1 SLC6A3 SLC6A3 NR3C1 NR3C1 CRKL CRKL GDF11 GDF11 NKX2-5 NKX2-5 SHH SHH NR0B1 NR0B1 M91_00016 M91_00016 HOXD3 HOXD3 BMP2 BMP2 PDGFRA PDGFRA STRA6 STRA6 BMPR1A BMPR1A PDPK1 PDPK1 NEUROG3 NEUROG3 CRH CRH BHLHA15 BHLHA15 BRAF BRAF BMP4 BMP4 FGF2 FGF2 SIDT2 SIDT2 WNT5A WNT5A CDK6 CDK6 HESX1 HESX1 SRF SRF DRD2 DRD2 HES1 HES1 ARID5B ARID5B ENSBMUP00000014874 ENSBMUP00000014874 ANXA1 ANXA1 NF1 NF1 RAF1 RAF1 VHL VHL IL6R IL6R OTP OTP CITED2 CITED2 GHRHR GHRHR CREB1 CREB1 SALL1 SALL1 DKK3 DKK3 PAX8 PAX8 ENSBMUP00000010625 ENSBMUP00000010625 WT1 WT1 PAX6 PAX6 TGFBR1 TGFBR1 SMAD3 SMAD3 MAP2K1 MAP2K1 ISL1 ISL1 LHX3 LHX3 NKX6-1 NKX6-1 THRA THRA NKX2-2 NKX2-2 PAX1 PAX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXA2Hepatocyte nuclear factor 3-beta. (461 aa)
GCM2Chorion-specific transcription factor GCMb. (507 aa)
NKX2-1NK2 homeobox 1. (400 aa)
MAPK1Mitogen-activated protein kinase. (332 aa)
HOXA3Homeobox A3. (440 aa)
HOXA5Homeobox A5. (272 aa)
EDN1Endothelin-1. (202 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
PROP1Homeobox protein prophet of Pit-1. (223 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (464 aa)
PAX4Paired box protein Pax-4. (339 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (687 aa)
GLI1Zinc finger protein GLI1. (1064 aa)
ENSBMUP00000034194annotation not available (270 aa)
ARMC5Armadillo repeat containing 5. (927 aa)
SIX1Homeobox protein SIX1. (284 aa)
CRHR1Corticotropin releasing hormone receptor 1. (415 aa)
CDH2Cadherin-2; Cadherins are calcium-dependent cell adhesion proteins. (821 aa)
ONECUT1One cut domain family member. (465 aa)
SMOSmoothened-like protein; Belongs to the G-protein coupled receptor Fz/Smo family. (778 aa)
PDX1Pancreas/duodenum homeobox protein 1. (283 aa)
DUOX2Dual oxidase 2. (1296 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
ONECUT2One cut domain family member 2. (496 aa)
ENSBMUP00000029231annotation not available (564 aa)
RFX6DNA-binding protein RFX6. (927 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PITX1Pituitary homeobox 1. (315 aa)
HOXB3Homeobox protein Hox-B3. (422 aa)
GHRHSomatoliberin. (106 aa)
GIPGastric inhibitory polypeptide. (155 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
NR5A1Steroidogenic factor 1. (461 aa)
SLC6A3Solute carrier family 6 member 3. (620 aa)
NR3C1Glucocorticoid receptor. (781 aa)
CRKLCrk-like protein. (302 aa)
GDF11Growth/differentiation factor 11. (407 aa)
NKX2-5Homeobox protein Nkx-2.5. (323 aa)
SHHSonic hedgehog protein. (453 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (469 aa)
M91_00016Bone morphogenetic protein 6. (239 aa)
HOXD3Homeobox protein Hox-D3. (376 aa)
BMP2Bone morphogenetic protein 2. (380 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
STRA6Stimulated by retinoic acid 6 protein-like protein. (660 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (566 aa)
NEUROG3Neurogenin-3. (215 aa)
CRHCorticoliberin. (190 aa)
BHLHA15Class A basic helix-loop-helix protein 15. (186 aa)
BRAFSerine/threonine-protein kinase B-raf. (790 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
SIDT2SID1 transmembrane family member 2. (835 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
CDK6Cell division protein kinase 6; Belongs to the protein kinase superfamily. (326 aa)
HESX1Homeobox expressed in ES cells 1. (178 aa)
SRFSerum response factor. (467 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (443 aa)
HES1Transcription factor HES-1. (269 aa)
ARID5BAT-rich interactive domain-containing protein 5B. (1181 aa)
ENSBMUP00000014874annotation not available (279 aa)
ANXA1Annexin. (346 aa)
NF1Neurofibromin. (2848 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
VHLVon Hippel-Lindau disease tumor suppressor. (216 aa)
IL6RInterleukin-6 receptor subunit alpha. (399 aa)
OTPHomeobox protein orthopedia. (326 aa)
CITED2Cbp/p300-interacting transactivator 2. (275 aa)
GHRHRGrowth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
SALL1Sal-like protein 1. (1032 aa)
DKK3Dickkopf-related protein 3. (323 aa)
PAX8Paired box protein Pax-8. (457 aa)
ENSBMUP00000010625annotation not available (202 aa)
WT1WT1 transcription factor. (518 aa)
PAX6Paired box protein Pax-6. (436 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (503 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
ISL1Insulin enhancer protein ISL-1. (349 aa)
LHX3LIM homeobox 3. (391 aa)
NKX6-1Homeobox protein Nkx-6.1. (89 aa)
THRAThyroid hormone receptor alpha. (511 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
PAX1Paired box protein Pax-1. (359 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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