(32 nodes) Telomeric DNA binding network (Bos mutus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102269300	Heterogeneous nuclear ribonucleoproteins A2/B1. (366 aa)
	UPF1	Regulator of nonsense transcripts 1. (1130 aa)
	XRCC5	X-ray repair cross-complementing protein 5. (733 aa)
	XRCC6	X-ray repair cross-complementing protein 6. (612 aa)
	POT1	Protection of telomeres protein 1. (473 aa)
	NABP2	Nucleic acid binding protein 2. (252 aa)
	HMBOX1	Homeobox-containing protein 1. (444 aa)
	TERF1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (438 aa)
	M91_06823	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1232 aa)
	TP53BP1	Tumor suppressor p53-binding protein 1. (1965 aa)
	SMG6	Telomerase-binding protein EST1A. (1345 aa)
	SMG7	Protein SMG7. (1178 aa)
	HNRNPD	Heterogeneous nuclear ribonucleoprotein D0. (345 aa)
	TERF2IP	Telomeric repeat-binding factor 2-interacting protein 1. (399 aa)
	TELO2	Telomere length regulation protein TEL2-like protein. (822 aa)
	CTC1	CST telomere replication complex component 1. (1209 aa)
	ENSBMUP00000032108	annotation not available (138 aa)
	TINF2	TERF1-interacting nuclear factor 2. (463 aa)
	SMG1	Serine/threonine-protein kinase SMG1; Belongs to the PI3/PI4-kinase family. (3634 aa)
	ZBTB10	Zinc finger and BTB domain-containing protein 10. (871 aa)
	PIF1	ATP-dependent DNA helicase PIF1. (642 aa)
	ACD	Adrenocortical dysplasia protein-like protein. (455 aa)
	TERF2	Telomeric repeat-binding factor 2. (540 aa)
	M91_14802	Uncharacterized protein. (581 aa)
	ZBTB48	Zinc finger and BTB domain-containing protein 48. (688 aa)
	STN1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (371 aa)
	TEN1	CST complex subunit TEN1. (252 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	APEX1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
	UPF2	Regulator of nonsense transcripts 2. (1269 aa)
	SMG5	Protein SMG5. (1016 aa)
	RAD50	DNA repair protein RAD50. (1311 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	CTC1	ENSBMUP00000004402	ENSBMUP00000029975	Adrenocortical dysplasia protein-like protein.	CST telomere replication complex component 1.	0.531
ACD	M91_06823	ENSBMUP00000004402	ENSBMUP00000026528	Adrenocortical dysplasia protein-like protein.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.871
ACD	POT1	ENSBMUP00000004402	ENSBMUP00000022570	Adrenocortical dysplasia protein-like protein.	Protection of telomeres protein 1.	0.997
ACD	RPA1	ENSBMUP00000004402	ENSBMUP00000013619	Adrenocortical dysplasia protein-like protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.503
ACD	STN1	ENSBMUP00000004402	ENSBMUP00000000841	Adrenocortical dysplasia protein-like protein.	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	0.780
ACD	TEN1	ENSBMUP00000004402	ENSBMUP00000012946	Adrenocortical dysplasia protein-like protein.	CST complex subunit TEN1.	0.683
ACD	TERF1	ENSBMUP00000004402	ENSBMUP00000025319	Adrenocortical dysplasia protein-like protein.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.944
ACD	TERF2	ENSBMUP00000004402	ENSBMUP00000001761	Adrenocortical dysplasia protein-like protein.	Telomeric repeat-binding factor 2.	0.980
ACD	TERF2IP	ENSBMUP00000004402	ENSBMUP00000029199	Adrenocortical dysplasia protein-like protein.	Telomeric repeat-binding factor 2-interacting protein 1.	0.983
ACD	TINF2	ENSBMUP00000004402	ENSBMUP00000033472	Adrenocortical dysplasia protein-like protein.	TERF1-interacting nuclear factor 2.	0.997
APEX1	RPA1	ENSBMUP00000016052	ENSBMUP00000013619	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.638
APEX1	TP53BP1	ENSBMUP00000016052	ENSBMUP00000027011	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Tumor suppressor p53-binding protein 1.	0.452
APEX1	XRCC5	ENSBMUP00000016052	ENSBMUP00000021451	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	X-ray repair cross-complementing protein 5.	0.452
CTC1	ACD	ENSBMUP00000029975	ENSBMUP00000004402	CST telomere replication complex component 1.	Adrenocortical dysplasia protein-like protein.	0.531
CTC1	M91_06823	ENSBMUP00000029975	ENSBMUP00000026528	CST telomere replication complex component 1.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.508
CTC1	POT1	ENSBMUP00000029975	ENSBMUP00000022570	CST telomere replication complex component 1.	Protection of telomeres protein 1.	0.821
CTC1	STN1	ENSBMUP00000029975	ENSBMUP00000000841	CST telomere replication complex component 1.	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	0.994
CTC1	TELO2	ENSBMUP00000029975	ENSBMUP00000029520	CST telomere replication complex component 1.	Telomere length regulation protein TEL2-like protein.	0.470
CTC1	TEN1	ENSBMUP00000029975	ENSBMUP00000012946	CST telomere replication complex component 1.	CST complex subunit TEN1.	0.993
CTC1	TERF1	ENSBMUP00000029975	ENSBMUP00000025319	CST telomere replication complex component 1.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.705