STRINGSTRING
CSMD2 CSMD2 RACK1 RACK1 HK3 HK3 PRKACA PRKACA BACE2 BACE2 FAM3B FAM3B NOX4 NOX4 FOXA3 FOXA3 SLC8B1 SLC8B1 FOXO3 FOXO3 CCDC186 CCDC186 G6PC G6PC GPR1 GPR1 WFS1 WFS1 INS INS FOXK1 FOXK1 RBM4 RBM4 ALOX5 ALOX5 RFX6 RFX6 CSRP3 CSRP3 HNF1A HNF1A IL6 IL6 SELENOT SELENOT HKDC1 HKDC1 TRPV4 TRPV4 PDK2 PDK2 FBN1 FBN1 GPI GPI TFAP2B TFAP2B CCN4 CCN4 SIRT1 SIRT1 PDX1 PDX1 CARTPT CARTPT AGER AGER SSTR5 SSTR5 GAS6 GAS6 RBP4 RBP4 NR1H4 NR1H4 NUCKS1 NUCKS1 PCK2 PCK2 HIF1A HIF1A PIK3R2 PIK3R2 RAB11B RAB11B INSR INSR PTPRN PTPRN PRKAA1 PRKAA1 GCK GCK AKT1 AKT1 ASPSCR1 ASPSCR1 GCGR GCGR CRTC2 CRTC2 SUCNR1 SUCNR1 GCG GCG MCU MCU PCK1 PCK1 LEPR LEPR FABP5 FABP5 PIK3CA PIK3CA FFAR3 FFAR3 TCF7L2 TCF7L2 STAT3 STAT3 DUPD1 DUPD1 FOXA1 FOXA1 ZBTB20 ZBTB20 FOXK2 FOXK2 PTCH1 PTCH1 SESN3 SESN3 HK1 HK1 BHLHA15 BHLHA15 BAD BAD KLF7 KLF7 CRY2 CRY2 SLC39A14 SLC39A14 SIDT2 SIDT2 HK2 HK2 DHPS DHPS CAV3 CAV3 KCNB1 KCNB1 CYP7A1 CYP7A1 SLC37A4 SLC37A4 CSMD1 CSMD1 CYB5R4 CYB5R4 RAF1 RAF1 PRCP PRCP PTPN2 PTPN2 M91_10244 M91_10244 TRA2B TRA2B INPP5K INPP5K PIK3R1 PIK3R1 RPH3AL RPH3AL PRKAA2 PRKAA2 PTPN11 PTPN11 ERN1 ERN1 ADIPOR2 ADIPOR2 MLXIPL MLXIPL PAX6 PAX6 PDK4 PDK4 APPL2 APPL2 HECTD4 HECTD4 RMI1 RMI1 SLC2A4 SLC2A4 POMC POMC PLSCR3 PLSCR3 RAB11FIP2 RAB11FIP2 VGF VGF NCOA5 NCOA5 ADCY8 ADCY8 STXBP5L STXBP5L PYGL PYGL ADIPOR1 ADIPOR1 IGF1R IGF1R STXBP3 STXBP3 M91_11552 M91_11552 MBD5 MBD5 STK11 STK11 ANKRD26 ANKRD26 LOC102272345 LOC102272345 CRY1 CRY1 NR1D1 NR1D1 LRRC8D LRRC8D M91_09989 M91_09989 ADGRF5 ADGRF5 HNF4A HNF4A LEP LEP PTPRN2 PTPRN2 PFKM PFKM SIN3A SIN3A PARK7 PARK7 KAT5 KAT5 LRRC8A LRRC8A ADIPOQ ADIPOQ SLC12A6 SLC12A6 NEUROD1 NEUROD1 DBH DBH NGFR NGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSMD2CUB and sushi domain-containing protein 2. (3631 aa)
RACK1Guanine nucleotide-binding protein subunit beta-2-like 1 protein. (317 aa)
HK3Hexokinase-3. (924 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (349 aa)
BACE2Beta-secretase 2; Belongs to the peptidase A1 family. (514 aa)
FAM3BProtein FAM3B. (235 aa)
NOX4NADPH oxidase 4. (550 aa)
FOXA3Hepatocyte nuclear factor 3-gamma. (335 aa)
SLC8B1Sodium/potassium/calcium exchanger 6; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (584 aa)
FOXO3Forkhead box protein O3. (453 aa)
CCDC186Uncharacterized protein. (904 aa)
G6PCGlucose-6-phosphatase catalytic subunit. (356 aa)
GPR1Putative G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
WFS1Wolframin. (871 aa)
INSInsulin. (99 aa)
FOXK1Forkhead box protein K1. (597 aa)
RBM4RNA-binding protein 4. (362 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
RFX6DNA-binding protein RFX6. (927 aa)
CSRP3Cysteine and glycine-rich protein 3. (216 aa)
HNF1AHepatocyte nuclear factor 1-alpha. (633 aa)
IL6Interleukin-6. (254 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (194 aa)
HKDC1Putative hexokinase HKDC1. (917 aa)
TRPV4Transient receptor putative cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
PDK2Protein-serine/threonine kinase. (415 aa)
FBN1Fibrillin-1. (2773 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (584 aa)
TFAP2BTranscription factor AP-2-beta. (460 aa)
CCN4WNT1 inducible signaling pathway protein 1. (281 aa)
SIRT1NAD-dependent deacetylase sirtuin-1. (454 aa)
PDX1Pancreas/duodenum homeobox protein 1. (283 aa)
CARTPTCocaine-and amphetamine-regulated transcript protein. (116 aa)
AGERAdvanced glycosylation end-product specific receptor. (416 aa)
SSTR5Somatostatin receptor type 5; Belongs to the G-protein coupled receptor 1 family. (368 aa)
GAS6Growth arrest specific 6. (614 aa)
RBP4Retinol-binding protein 4. (201 aa)
NR1H4Bile acid receptor. (486 aa)
NUCKS1Nuclear ubiquitous casein and cyclin-dependent kinases substrate. (237 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
RAB11BRas-related protein Rab-11B. (218 aa)
INSRInsulin receptor. (1382 aa)
PTPRNReceptor-type tyrosine-protein phosphatase-like N. (979 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
GCKPhosphotransferase. (466 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
ASPSCR1ASPSCR1, UBX domain containing tether for SLC2A4. (612 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (479 aa)
CRTC2CREB-regulated transcription coactivator 2. (693 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (316 aa)
GCGGlucagon. (180 aa)
MCUCoiled-coil domain-containing protein 109A. (314 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
LEPRLeptin receptor. (1165 aa)
FABP5Fatty acid-binding protein, epidermal; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
FFAR3Free fatty acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (365 aa)
TCF7L2Transcription factor 7-like 2. (536 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
DUPD1Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (210 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (468 aa)
ZBTB20Zinc finger and BTB domain-containing protein 20. (788 aa)
FOXK2Forkhead box protein K2. (605 aa)
PTCH1Protein patched-like protein 1. (1459 aa)
SESN3Sestrin-3. (492 aa)
HK1Hexokinase 1. (839 aa)
BHLHA15Class A basic helix-loop-helix protein 15. (186 aa)
BADBcl2 antagonist of cell death. (168 aa)
KLF7Krueppel-like factor 7. (302 aa)
CRY2Cryptochrome-2. (614 aa)
SLC39A14Zinc transporter ZIP14. (490 aa)
SIDT2SID1 transmembrane family member 2. (835 aa)
HK2Hexokinase-2. (917 aa)
DHPSDeoxyhypusine synthase. (369 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (822 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (500 aa)
SLC37A4MFS domain-containing protein. (451 aa)
CSMD1CUB and sushi domain-containing protein. (3288 aa)
CYB5R4Cytochrome b5 reductase 4. (520 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (668 aa)
PRCPLysosomal Pro-X carboxypeptidase. (499 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (393 aa)
M91_10244ANK_REP_REGION domain-containing protein. (310 aa)
TRA2BTransformer 2 beta homolog (Drosophila). (288 aa)
INPP5KInositol polyphosphate 5-phosphatase K. (489 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
RPH3ALRabphilin 3A-like (without C2 domains). (317 aa)
PRKAA2Non-specific serine/threonine protein kinase. (533 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (593 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (956 aa)
ADIPOR2Adiponectin receptor protein 2. (386 aa)
MLXIPLWilliams-Beuren syndrome chromosomal region 14 protein. (856 aa)
PAX6Paired box protein Pax-6. (436 aa)
PDK4Protein-serine/threonine kinase. (407 aa)
APPL2DCC-interacting protein 13-beta. (664 aa)
HECTD4HECT domain E3 ubiquitin protein ligase 4. (4275 aa)
RMI1RecQ-mediated genome instability protein 1. (624 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
POMCPro-opiomelanocortin. (264 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (358 aa)
RAB11FIP2Rab11 family-interacting protein 2. (511 aa)
VGFNeurosecretory protein VGF. (616 aa)
NCOA5Nuclear receptor coactivator 5. (579 aa)
ADCY8Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1251 aa)
STXBP5LSyntaxin-binding protein 5-like protein. (1045 aa)
PYGLGlycogen phosphorylase L. (851 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
STXBP3Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (542 aa)
M91_11552DUF3496 domain-containing protein. (511 aa)
MBD5Methyl-CpG-binding domain protein 5. (1730 aa)
STK11Serine/threonine-protein kinase 11; Belongs to the protein kinase superfamily. (438 aa)
ANKRD26ANK_REP_REGION domain-containing protein. (270 aa)
LOC102272345Olfactory receptor. (313 aa)
CRY1Cryptochrome-1. (587 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (571 aa)
LRRC8DLeucine-rich repeat-containing protein 8D. (858 aa)
M91_09989CCDC144C domain-containing protein. (310 aa)
ADGRF5Putative G-protein coupled receptor 116; Belongs to the G-protein coupled receptor 2 family. (983 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (464 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
PTPRN2Receptor-type tyrosine-protein phosphatase N2. (595 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (850 aa)
SIN3APaired amphipathic helix protein Sin3a. (1274 aa)
PARK7Protein DJ-1. (189 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
LRRC8ALeucine-rich repeat-containing protein 8A. (810 aa)
ADIPOQAdiponectin. (246 aa)
SLC12A6Solute carrier family 12 member 6. (1150 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
DBHDopamine beta-hydroxylase. (610 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (428 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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