STRINGSTRING
SH3RF2 SH3RF2 LOC102277086 LOC102277086 ARIH1 ARIH1 IL1B IL1B GSK3A GSK3A GABARAP GABARAP PSMC5 PSMC5 PIAS1 PIAS1 HAMP HAMP FBXL5 FBXL5 DTL DTL ITCH ITCH GPC3 GPC3 RNFT1 RNFT1 PLK2 PLK2 OAZ2 OAZ2 RNF180 RNF180 SGSM3 SGSM3 LOC102278977 LOC102278977 LOC102278697 LOC102278697 DAB2IP DAB2IP COP1 COP1 PSMC6 PSMC6 NOP53 NOP53 APC2 APC2 LOC102284805 LOC102284805 APC APC DET1 DET1 TRIB2 TRIB2 ANKIB1 ANKIB1 FBXO22 FBXO22 RCHY1 RCHY1 EZR EZR ENSBMUP00000002516 ENSBMUP00000002516 SNX33 SNX33 SNX9 SNX9 NSF NSF DACT1 DACT1 LDLR LDLR OSBPL7 OSBPL7 GPLD1 GPLD1 SNF8 SNF8 ASB9 ASB9 HERPUD1 HERPUD1 ASB11 ASB11 GSK3B GSK3B SOCS5 SOCS5 TRIB1 TRIB1 RDX RDX LOC102286770 LOC102286770 NUPR1 NUPR1 AKT1 AKT1 DAB2 DAB2 DNAJB2 DNAJB2 LRP1 LRP1 NKD1 NKD1 MARCHF2 MARCHF2 AXIN2 AXIN2 RNF19A RNF19A C4BPB C4BPB CSNK1D CSNK1D RHBDD3 RHBDD3 ENSBMUP00000033165 ENSBMUP00000033165 OAZ3 OAZ3 PSMC3 PSMC3 HSPBP1 HSPBP1 CD81 CD81 AXIN1 AXIN1 DVL1 DVL1 TREM2 TREM2 RNF185 RNF185 RNF144A RNF144A VIP VIP PACSIN3 PACSIN3 STX5 STX5 VCP VCP BBS7 BBS7 TMTC3 TMTC3 CDC20B CDC20B EGLN2 EGLN2 ENSBMUP00000030625 ENSBMUP00000030625 RNF14 RNF14 PLK1 PLK1 NDFIP1 NDFIP1 CUL4B CUL4B CLUL1 CLUL1 ASB5 ASB5 MSN MSN LOC102266620 LOC102266620 ZER1 ZER1 LOC102264877 LOC102264877 PSMD10 PSMD10 SH3D19 SH3D19 DDRGK1 DDRGK1 DDA1 DDA1 PRICKLE1 PRICKLE1 TIPARP TIPARP ADAM8 ADAM8 APOE APOE LPCAT1 LPCAT1 YJEFN3 YJEFN3 SH3RF1 SH3RF1 SIRT6 SIRT6 UBQLN1 UBQLN1 RACK1 RACK1 LOC102277263 LOC102277263 FOXO1 FOXO1 RNF41 RNF41 ZYG11A ZYG11A ZYG11B ZYG11B DDB1 DDB1 ENSBMUP00000022581 ENSBMUP00000022581 PLK3 PLK3 USP13 USP13 CDC20 CDC20 NRDC NRDC AURKA AURKA CSNK2A1 CSNK2A1 PSMC4 PSMC4 TRIB3 TRIB3 LRRK2 LRRK2 RAD23A RAD23A ENSBMUP00000019589 ENSBMUP00000019589 TRIM32 TRIM32 SIRT2 SIRT2 ECSCR ECSCR RAB7A RAB7A BAG6 BAG6 BAG2 BAG2 CAV1 CAV1 FBXW7 FBXW7 TNF TNF OAZ1 OAZ1 WNT5A WNT5A SGTA SGTA SMAD7 SMAD7 M91_18991 M91_18991 RNF217 RNF217 TNFRSF1B TNFRSF1B CBFA2T3 CBFA2T3 UBQLN2 UBQLN2 RNF144B RNF144B GBA GBA GJA1 GJA1 FZR1 FZR1 NKD2 NKD2 PSMC1 PSMC1 AMER1 AMER1 FBXW9 FBXW9 SEC22B SEC22B FBXW8 FBXW8 RNFT2 RNFT2 M91_14422 M91_14422 BCAP31 BCAP31 MAPK9 MAPK9 MYLIP MYLIP IFNG IFNG TMEM259 TMEM259 VPS35 VPS35 CBLB CBLB MKRN2 MKRN2 PSMC2 PSMC2 LOC102284329 LOC102284329 SOCS4 SOCS4 TNFAIP3 TNFAIP3 PSEN1 PSEN1 LOC102270304 LOC102270304 SORL1 SORL1 USP5 USP5 CDKN1B CDKN1B RNF19B RNF19B GGA1 GGA1 KCNE2 KCNE2 NEDD4 NEDD4 GGA3 GGA3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SH3RF2Putative E3 ubiquitin-protein ligase SH3RF2. (728 aa)
LOC102277086NEDD8 ultimate buster 1. (402 aa)
ARIH1RBR-type E3 ubiquitin transferase. (539 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
PSMC526S protease regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
PIAS1E3 SUMO-protein ligase PIAS1. (651 aa)
HAMPHepcidin. (82 aa)
FBXL5F-box and leucine rich repeat protein 5. (691 aa)
DTLDenticleless protein-like protein. (730 aa)
ITCHE3 ubiquitin-protein ligase Itchy. (862 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
RNFT1RING finger and transmembrane domain-containing protein 1. (433 aa)
PLK2Serine/threonine-protein kinase PLK. (659 aa)
OAZ2Ornithine decarboxylase antizyme 2. (189 aa)
RNF180E3 ubiquitin-protein ligase RNF180. (592 aa)
SGSM3Small G protein signaling modulator 3. (745 aa)
LOC102278977Heat shock 70 kDa protein 1B; Belongs to the heat shock protein 70 family. (633 aa)
LOC102278697Heat shock 70 kDa protein 1A; Belongs to the heat shock protein 70 family. (599 aa)
DAB2IPDAB2 interacting protein. (1119 aa)
COP1E3 ubiquitin-protein ligase RFWD2. (731 aa)
PSMC626S proteasome regulatory subunit T4. (403 aa)
NOP53Glioma tumor suppressor candidate region 2 protein. (483 aa)
APC2Adenomatous polyposis coli protein 2. (2316 aa)
LOC102284805RBR-type E3 ubiquitin transferase. (176 aa)
APCAdenomatous polyposis coli protein. (2879 aa)
DET1DET1-like protein. (561 aa)
TRIB2Tribbles-like protein 2. (343 aa)
ANKIB1Ankyrin repeat and IBR domain-containing protein 1. (1089 aa)
FBXO22F-box only protein 22. (404 aa)
RCHY1RING finger and CHY zinc finger domain-containing protein 1. (261 aa)
EZREzrin. (659 aa)
ENSBMUP00000002516annotation not available (795 aa)
SNX33Sorting nexin. (571 aa)
SNX9Sorting nexin-9. (600 aa)
NSFVesicle-fusing ATPase. (770 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (836 aa)
LDLRLow-density lipoprotein receptor. (844 aa)
OSBPL7Oxysterol-binding protein; Belongs to the OSBP family. (842 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (801 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
ASB9Ankyrin repeat and SOCS box protein 9. (287 aa)
HERPUD1Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein. (395 aa)
ASB11Ankyrin repeat and SOCS box protein 11. (312 aa)
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (432 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
TRIB1Tribbles-like protein 1. (365 aa)
RDXRadixin. (604 aa)
LOC102286770Casein kinase I isoform epsilon; Belongs to the protein kinase superfamily. (416 aa)
NUPR1Nuclear protein 1. (82 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
DAB2Disabled-like protein 2. (768 aa)
DNAJB2DnaJ-like protein subfamily B member 2. (312 aa)
LRP1Low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor). (4542 aa)
NKD1Protein naked cuticle-like protein 1. (471 aa)
MARCHF2E3 ubiquitin-protein ligase MARCH2. (245 aa)
AXIN2Axin-2. (771 aa)
RNF19ARBR-type E3 ubiquitin transferase. (838 aa)
C4BPBComplement component 4 binding protein beta. (209 aa)
CSNK1DCasein kinase I isoform delta. (417 aa)
RHBDD3Rhomboid domain-containing protein 3. (386 aa)
ENSBMUP00000033165annotation not available (138 aa)
OAZ3Ornithine decarboxylase antizyme 3. (240 aa)
PSMC326S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (440 aa)
HSPBP1Hsp70-binding protein 1. (357 aa)
CD81Tetraspanin. (273 aa)
AXIN1Axin-1. (865 aa)
DVL1Segment polarity protein dishevelled-like protein DVL-1. (691 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (244 aa)
RNF185RING finger protein 185. (192 aa)
RNF144ARBR-type E3 ubiquitin transferase. (352 aa)
VIPVIP peptide. (170 aa)
PACSIN3Protein kinase C and casein kinase substrate in neurons protein 3. (421 aa)
STX5Syntaxin-5; Belongs to the syntaxin family. (355 aa)
VCPTransitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (806 aa)
BBS7Bardet-Biedl syndrome 7 protein. (715 aa)
TMTC3Transmembrane and TPR repeat-containing protein 3. (915 aa)
CDC20BCell division cycle protein 20-like protein B. (514 aa)
EGLN2Egl nine-like protein 2. (415 aa)
ENSBMUP00000030625annotation not available (81 aa)
RNF14RBR-type E3 ubiquitin transferase. (474 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
NDFIP1NEDD4 family-interacting protein 1. (210 aa)
CUL4BCullin-4B; Belongs to the cullin family. (916 aa)
CLUL1Clusterin; Belongs to the clusterin family. (469 aa)
ASB5Ankyrin repeat and SOCS box protein 5. (320 aa)
MSNMoesin. (577 aa)
LOC102266620NEDD8 ultimate buster 1-like. (241 aa)
ZER1Protein zer-1-like protein. (766 aa)
LOC102264877DET1-and DDB1-associated protein 1. (100 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10. (269 aa)
SH3D19SH3 domain-containing protein 19. (1040 aa)
DDRGK1DDRGK domain-containing protein 1. (313 aa)
DDA1DET1-and DDB1-associated protein 1. (105 aa)
PRICKLE1Prickle-like protein 1. (834 aa)
TIPARPTCDD-inducible poly [ADP-ribose] polymerase. (656 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8. (800 aa)
APOEApolipoprotein E. (326 aa)
LPCAT1Lysophosphatidylcholine acyltransferase 1. (463 aa)
YJEFN3NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (371 aa)
SH3RF1Putative E3 ubiquitin-protein ligase SH3RF1. (894 aa)
SIRT6NAD-dependent deacetylase sirtuin-6. (359 aa)
UBQLN1Ubiquilin-1. (589 aa)
RACK1Guanine nucleotide-binding protein subunit beta-2-like 1 protein. (317 aa)
LOC102277263Clusterin. (457 aa)
FOXO1Forkhead box protein O1. (468 aa)
RNF41E3 ubiquitin-protein ligase NRDP1. (317 aa)
ZYG11AProtein zyg-11-like protein A. (760 aa)
ZYG11BZyg-11 family member B, cell cycle regulator. (742 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
ENSBMUP00000022581annotation not available (345 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (861 aa)
CDC20Cell division cycle protein 20-like protein. (499 aa)
NRDCNardilysin. (1230 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (402 aa)
CSNK2A1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
PSMC426S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
TRIB3Tribbles-like protein 3. (357 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2. (2527 aa)
RAD23AUV excision repair protein RAD23-like protein A. (362 aa)
ENSBMUP00000019589annotation not available (193 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32. (650 aa)
SIRT2NAD-dependent deacetylase sirtuin-2. (353 aa)
ECSCREndothelial cell-specific chemotaxis regulator. (232 aa)
RAB7ARas-related protein Rab-7a. (247 aa)
BAG6Large proline-rich protein BAT3. (1164 aa)
BAG2BAG family molecular chaperone regulator 2. (207 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
FBXW7F-box/WD repeat-containing protein 7. (706 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
OAZ1Ornithine decarboxylase antizyme 1. (229 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
SGTASmall glutamine-rich tetratricopeptide repeat-containing protein alpha. (312 aa)
SMAD7Mothers against decapentaplegic homolog. (424 aa)
M91_18991RBR-type E3 ubiquitin transferase. (104 aa)
RNF217E3 ubiquitin-protein ligase RNF217. (275 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B. (438 aa)
CBFA2T3Protein CBFA2T3. (638 aa)
UBQLN2Ubiquilin-2. (624 aa)
RNF144BRBR-type E3 ubiquitin transferase. (304 aa)
GBAGlucosylceramidase. (536 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (383 aa)
FZR1Fizzy-related protein-like protein. (493 aa)
NKD2Protein naked cuticle-like protein 2. (287 aa)
PSMC126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
AMER1Protein FAM123B. (1118 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
SEC22BVesicle-trafficking protein SEC22b; Belongs to the synaptobrevin family. (215 aa)
FBXW8F-box/WD repeat-containing protein 8. (598 aa)
RNFT2RING finger and transmembrane domain-containing protein 2. (449 aa)
M91_14422DDA1 domain-containing protein. (118 aa)
BCAP31B-cell receptor-associated protein 31. (245 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MYLIPE3 ubiquitin-protein ligase MYLIP. (380 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TMEM259Membralin. (406 aa)
VPS35Vacuolar protein sorting-associated protein 35. (796 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (982 aa)
MKRN2Putative E3 ubiquitin-protein ligase makorin-2. (442 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
LOC102284329Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (674 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (780 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (478 aa)
LOC102270304E3 ubiquitin-protein ligase parkin. (279 aa)
SORL1Sortilin related receptor 1. (2123 aa)
USP5Ubiquitin carboxyl-terminal hydrolase 5/13. (858 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
RNF19BRing finger protein 19B. (464 aa)
GGA1ADP-ribosylation factor-binding protein GGA1. (634 aa)
KCNE2Potassium voltage-gated channel subfamily E member 2. (123 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4. (1321 aa)
GGA3ADP-ribosylation factor-binding protein GGA3. (703 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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