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IREB2 IREB2 LEP LEP TJP2 TJP2 VDR VDR LDLR LDLR NPC1L1 NPC1L1 VIL1 VIL1 NPC1 NPC1 PLS1 PLS1 F11R F11R ACO1 ACO1 LIMA1 LIMA1 SLC26A6 SLC26A6 GCNT3 GCNT3 SCARB1 SCARB1 UGCG UGCG PNLIP PNLIP CEL CEL EZR EZR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IREB2Iron-responsive element-binding protein 2; Belongs to the aconitase/IPM isomerase family. (964 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
TJP2Tight junction protein 2. (1118 aa)
VDRVitamin D3 receptor. (425 aa)
LDLRLow-density lipoprotein receptor. (844 aa)
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1333 aa)
VIL1Villin-1. (827 aa)
NPC1Niemann-Pick C1 protein. (1277 aa)
PLS1Plastin-1. (630 aa)
F11RJunctional adhesion molecule A. (303 aa)
ACO1Cytoplasmic aconitate hydratase; Belongs to the aconitase/IPM isomerase family. (899 aa)
LIMA1LIM domain and actin-binding protein 1. (760 aa)
SLC26A6Solute carrier family 26 member 6. (767 aa)
GCNT3Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3. (438 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (513 aa)
UGCGCeramide glucosyltransferase. (394 aa)
PNLIPTriacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (465 aa)
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (599 aa)
EZREzrin. (659 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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