(37 nodes) Phosphatidylinositol phosphate phosphatase activity network (Bos mutus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MTMR12	Myotubularin-related protein 12. (747 aa)
	PIP4P1	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
	PIP4P2	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
	MTMR14	Myotubularin-related protein 14. (649 aa)
	INPP5K	Inositol polyphosphate 5-phosphatase K. (489 aa)
	LOC102264329	Myotubularin-related protein 9. (543 aa)
	SYNJ1	Synaptojanin-1. (1563 aa)
	SACM1L	Phosphatidylinositide phosphatase SAC1. (587 aa)
	MTMR1	Myotubularin-related protein 1. (672 aa)
	MTM1	Myotubularin. (603 aa)
	INPP5E	72 kDa inositol polyphosphate 5-phosphatase. (656 aa)
	INPP5B	Inositol polyphosphate 5-phosphatase INPP5B/F. (912 aa)
	MTMR2	Myotubularin-related protein 2. (643 aa)
	INPP5F	Phosphatidylinositide phosphatase SAC2. (1133 aa)
	MTMR3	Myotubularin-related protein 3/4. (1195 aa)
	INPP4A	Type I inositol-3,4-bisphosphate 4-phosphatase. (976 aa)
	PTPMT1	Protein-tyrosine phosphatase mitochondrial 1. (295 aa)
	INPP5J	Inositol polyphosphate 5-phosphatase INPP5J/K. (943 aa)
	MTMR7	Myotubularin-related protein 7. (621 aa)
	MTMR11	Myotubularin-related protein 11. (665 aa)
	M91_03459	Uncharacterized protein. (124 aa)
	MTMR9	Myotubularin-related protein 9. (549 aa)
	SYNJ2	Synaptojanin-2. (1280 aa)
	PSORS1C2	Uncharacterized protein. (136 aa)
	CCDC180	Uncharacterized protein. (1708 aa)
	ENSBMUP00000003364	annotation not available (53 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	OCRL	Inositol polyphosphate 5-phosphatase OCRL-1. (901 aa)
	MTMR8	Myotubularin-related protein 8. (689 aa)
	SH2D1A	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (131 aa)
	MTMR10	Myotubularin-related protein 10. (764 aa)
	MTMR4	Myotubularin-related protein 4. (1197 aa)
	MTMR6	Myotubularin-related protein 6. (613 aa)
	LOC102284058	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2. (409 aa)
	FIG4	FIG4 phosphoinositide 5-phosphatase. (885 aa)
	DIPK2A	PIP49_C domain-containing protein. (409 aa)
	INPP4B	Type II inositol-3,4-bisphosphate 4-phosphatase. (759 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FIG4	MTM1	ENSBMUP00000023135	ENSBMUP00000003920	FIG4 phosphoinositide 5-phosphatase.	Myotubularin.	0.439
FIG4	MTMR2	ENSBMUP00000023135	ENSBMUP00000007186	FIG4 phosphoinositide 5-phosphatase.	Myotubularin-related protein 2.	0.606
INPP4A	INPP5B	ENSBMUP00000035806	ENSBMUP00000006502	Type I inositol-3,4-bisphosphate 4-phosphatase.	Inositol polyphosphate 5-phosphatase INPP5B/F.	0.932
INPP4A	INPP5E	ENSBMUP00000035806	ENSBMUP00000005243	Type I inositol-3,4-bisphosphate 4-phosphatase.	72 kDa inositol polyphosphate 5-phosphatase.	0.925
INPP4A	INPP5J	ENSBMUP00000035806	ENSBMUP00000032493	Type I inositol-3,4-bisphosphate 4-phosphatase.	Inositol polyphosphate 5-phosphatase INPP5J/K.	0.523
INPP4A	MTM1	ENSBMUP00000035806	ENSBMUP00000003920	Type I inositol-3,4-bisphosphate 4-phosphatase.	Myotubularin.	0.911
INPP4A	MTMR1	ENSBMUP00000035806	ENSBMUP00000003895	Type I inositol-3,4-bisphosphate 4-phosphatase.	Myotubularin-related protein 1.	0.923
INPP4A	MTMR14	ENSBMUP00000035806	ENSBMUP00000015455	Type I inositol-3,4-bisphosphate 4-phosphatase.	Myotubularin-related protein 14.	0.900
INPP4A	MTMR2	ENSBMUP00000035806	ENSBMUP00000007186	Type I inositol-3,4-bisphosphate 4-phosphatase.	Myotubularin-related protein 2.	0.912
INPP4A	MTMR3	ENSBMUP00000035806	ENSBMUP00000034124	Type I inositol-3,4-bisphosphate 4-phosphatase.	Myotubularin-related protein 3/4.	0.908
INPP4A	MTMR4	ENSBMUP00000035806	ENSBMUP00000027735	Type I inositol-3,4-bisphosphate 4-phosphatase.	Myotubularin-related protein 4.	0.908
INPP4A	MTMR6	ENSBMUP00000035806	ENSBMUP00000026382	Type I inositol-3,4-bisphosphate 4-phosphatase.	Myotubularin-related protein 6.	0.948
INPP4A	MTMR7	ENSBMUP00000035806	ENSBMUP00000031718	Type I inositol-3,4-bisphosphate 4-phosphatase.	Myotubularin-related protein 7.	0.932
INPP4A	MTMR8	ENSBMUP00000035806	ENSBMUP00000016286	Type I inositol-3,4-bisphosphate 4-phosphatase.	Myotubularin-related protein 8.	0.909
INPP4A	OCRL	ENSBMUP00000035806	ENSBMUP00000017695	Type I inositol-3,4-bisphosphate 4-phosphatase.	Inositol polyphosphate 5-phosphatase OCRL-1.	0.913
INPP4A	PTEN	ENSBMUP00000035806	ENSBMUP00000008299	Type I inositol-3,4-bisphosphate 4-phosphatase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.932
INPP4A	SYNJ1	ENSBMUP00000035806	ENSBMUP00000010777	Type I inositol-3,4-bisphosphate 4-phosphatase.	Synaptojanin-1.	0.947
INPP4A	SYNJ2	ENSBMUP00000035806	ENSBMUP00000002269	Type I inositol-3,4-bisphosphate 4-phosphatase.	Synaptojanin-2.	0.925
INPP4B	M91_03459	ENSBMUP00000019255	ENSBMUP00000000630	Type II inositol-3,4-bisphosphate 4-phosphatase.	Uncharacterized protein.	0.897
INPP4B	PTEN	ENSBMUP00000019255	ENSBMUP00000008299	Type II inositol-3,4-bisphosphate 4-phosphatase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.444