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| | FTSJ1 | Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (329 aa) |
| | NSD3 | Histone-lysine N-methyltransferase NSD3. (1439 aa) |
| | SETD7 | Histone-lysine N-methyltransferase SETD7. (384 aa) |
| | KMT2A | Histone-lysine N-methyltransferase MLL. (3957 aa) |
| | PCMT1 | Protein-L-isoaspartate O-methyltransferase. (285 aa) |
| | WDR4 | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (453 aa) |
| | TPMT | Thiopurine S-methyltransferase. (245 aa) |
| | TRMT61B | Putative tRNA (Adenine-N(1)-)-methyltransferase catalytic subunit TRMT61B. (496 aa) |
| | KDM1B | Lysine-specific histone demethylase 1B. (821 aa) |
| | RRP8 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (460 aa) |
| | PCMTD1 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 1. (356 aa) |
| | ASH1L | Putative histone-lysine N-methyltransferase ASH1L. (2965 aa) |
| | DNMT3L | DNA (Cytosine-5)-methyltransferase 3-like protein. (387 aa) |
| | TRMT11 | tRNA guanosine-2'-O-methyltransferase TRM11-like protein. (459 aa) |
| | KMT5A | Histone-lysine N-methyltransferase SETD8. (352 aa) |
| | DOT1L | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1533 aa) |
| | M91_21227 | Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (363 aa) |
| | LOC102268256 | Histone-lysine N-methyltransferase SETMAR. (306 aa) |
| | TRMT112 | tRNA methyltransferase 112-like protein. (125 aa) |
| | DNMT3B | DNA (Cytosine-5)-methyltransferase 3B; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (856 aa) |
| | KDM1A | Lysine-specific histone demethylase 1A. (876 aa) |
| | LOC102270564 | Methyltransferase-like protein 7A. (224 aa) |
| | TRMT1 | N(2),N(2)-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (676 aa) |
| | NSUN3 | Putative methyltransferase NSUN3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (340 aa) |
| | SETD2 | Histone-lysine N-methyltransferase SETD2. (2567 aa) |
| | SHMT1 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa) |
| | FBL | rRNA 2'-O-methyltransferase fibrillarin. (322 aa) |
| | EZH1 | Histone-lysine N-methyltransferase EZH1. (747 aa) |
| | COMTD1 | Catechol O-methyltransferase domain-containing protein 1. (262 aa) |
| | TRMT6 | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (497 aa) |
| | NSUN7 | Putative methyltransferase NSUN7; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (722 aa) |
| | M91_02516 | Histone-lysine N-methyltransferase PRDM9. (668 aa) |
| | KDM4A | Lysine-specific demethylase 4A. (1065 aa) |
| | PEMT | Phosphatidylethanolamine N-methyltransferase. (182 aa) |
| | KDM7A | Lysine-specific demethylase 7. (942 aa) |
| | KMT2B | Histone-lysine N-methyltransferase MLL4. (2713 aa) |
| | PRMT2 | Protein arginine N-methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (434 aa) |
| | MTR | Methionine synthase. (886 aa) |
| | BHMT | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. (407 aa) |
| | BHMT2 | Betaine--homocysteine S-methyltransferase 2. (357 aa) |
| | METTL3 | N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (580 aa) |
| | LOC102277953 | Transmembrane O-methyltransferase. (258 aa) |
| | KDM2B | Lysine-specific demethylase 2B. (1285 aa) |
| | PRMT8 | Protein arginine N-methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa) |
| | M91_10035 | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (239 aa) |
| | METTL7B | Methyltransferase-like protein 7B. (244 aa) |
| | PRMT5 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa) |
| | NSUN4 | Putative methyltransferase NSUN4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (384 aa) |
| | PHF8 | Histone lysine demethylase PHF8. (1060 aa) |
| | AMT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (403 aa) |
| | EEF1AKMT1 | EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family. (250 aa) |
| | MRM2 | Putative ribosomal RNA methyltransferase 2. (244 aa) |
| | HNMT | Histamine N-methyltransferase. (292 aa) |
| | KDM5C | Lysine-specific demethylase 5C. (1555 aa) |
| | LCMT2 | Leucine carboxyl methyltransferase 2. (39 aa) |
| | HEMK1 | HemK methyltransferase family member 1. (363 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1696 aa) |
| | TRMT61A | tRNA (Adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A. (300 aa) |
| | COQ5 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (330 aa) |
| | KDM2A | Lysine-specific demethylase 2A. (1219 aa) |
| | EZH2 | Histone-lysine N-methyltransferase EZH2. (646 aa) |
| | EEF1AKNMT | Methyltransferase-like protein 13. (699 aa) |
| | TRMT1L | TRM1-like protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (737 aa) |
| | M91_13497 | N-acetylserotonin O-methyltransferase-like protein. (238 aa) |
| | ASMT | Hydroxyindole O-methyltransferase. (345 aa) |
| | SUV39H2 | Histone-lysine N-methyltransferase SUV39H2. (350 aa) |
| | BCDIN3D | Putative methyltransferase BCDIN3D. (393 aa) |
| | M91_12513 | Methylated-DNA--protein-cysteine methyltransferase. (143 aa) |
| | TFB1M | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (339 aa) |
| | SETDB1 | Histone-lysine N-methyltransferase SETDB1. (1338 aa) |
| | PRMT9 | TPR_REGION domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (844 aa) |
| | KDM3B | Lysine-specific demethylase 3B. (1599 aa) |
| | SHMT2 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa) |
| | EHMT1 | Histone-lysine N-methyltransferase, H3 lysine-9 specific 5. (1273 aa) |
| | COQ3 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (370 aa) |
| | METTL1 | tRNA (guanine(46)-N(7))-methyltransferase. (277 aa) |
| | TRMT5 | tRNA (Guanine-N(1)-)-methyltransferase. (497 aa) |
| | METTL9 | Methyltransferase-like protein 9. (283 aa) |
| | METTL2A | Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (378 aa) |
| | PCMTD2 | Protein-L-isoaspartate O-methyltransferase domain-containing protein 2. (361 aa) |
| | NSUN2 | tRNA (Cytosine-5-)-methyltransferase NSUN2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (840 aa) |
| | BMT2 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa) |
| | METTL15 | Putative S-adenosyl-L-methionine-dependent methyltransferase METT5D1. (407 aa) |
| | ICMT | Protein-S-isoprenylcysteine O-methyltransferase. (188 aa) |
| | AS3MT | Arsenite methyltransferase. (374 aa) |
| | KDM3A | Lysine-specific demethylase 3A. (1323 aa) |
| | SETDB2 | Histone-lysine N-methyltransferase SETDB2. (700 aa) |
| | METTL4 | Methyltransferase-like protein 4; Belongs to the MT-A70-like family. (470 aa) |
| | PRMT7 | Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (695 aa) |
| | PNMT | Phenylethanolamine N-methyltransferase. (367 aa) |
| | TRMT10B | RNA (Guanine-9-)-methyltransferase domain-containing protein 3. (316 aa) |
| | METTL8 | Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (407 aa) |
| | TARBP1 | Putative methyltransferase TARBP1. (1602 aa) |
| | CYP51A1 | Lanosterol 14-alpha demethylase; Belongs to the cytochrome P450 family. (510 aa) |
| | KDM4C | Lysine-specific demethylase 4C. (740 aa) |
| | FBLL1 | rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1. (333 aa) |
| | METTL5 | Methyltransferase-like protein 5. (209 aa) |
| | RNMT | mRNA cap guanine-N7 methyltransferase. (477 aa) |
| | TRMT9B | Putative methyltransferase KIAA1456-like protein. (424 aa) |
| | DMAP1 | DNA methyltransferase 1-associated protein 1. (468 aa) |
| | PRMT6 | Protein arginine N-methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa) |
| | CARM1 | Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (614 aa) |
| | GAMT | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. (236 aa) |
| | SETD3 | Protein-histidine N-methyltransferase. (601 aa) |
| | PRMT1 | Protein arginine N-methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa) |
| | METTL14 | Methyltransferase-like protein 14; Belongs to the MT-A70-like family. (456 aa) |
| | N6AMT1 | HemK methyltransferase family member 2. (214 aa) |
| | TRMT2A | tRNA (Uracil-5-)-methyltransferase-like protein A; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (628 aa) |
| | KDM6A | Lysine-specific demethylase 6A. (1430 aa) |
| | EHMT2 | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3. (1268 aa) |
| | KMT5B | Histone-lysine N-methyltransferase SUV420H1. (883 aa) |
| | TRMT13 | tRNA guanosine-2'-O-methyltransferase TRM13-like protein. (481 aa) |
| | SUV39H1 | Histone-lysine N-methyltransferase SUV39H1. (414 aa) |
| | EEF1AKMT2 | Methyltransferase-like protein 10. (234 aa) |
| | NDUFAF7 | Protein arginine methyltransferase NDUFAF7; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). (441 aa) |
| | KMT2C | Histone-lysine N-methyltransferase MLL3. (4929 aa) |
| | KDM4D | Lysine-specific demethylase 4D. (500 aa) |
| | CMTR2 | FtsJ methyltransferase domain-containing protein 1. (764 aa) |
| | ASH2L | Set1/Ash2 histone methyltransferase complex subunit ASH2. (623 aa) |
| | FTSJ3 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (833 aa) |
| | DNMT3A | DNA (Cytosine-5)-methyltransferase 3A; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa) |
| | NSD1 | Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific. (2698 aa) |
| | KDM5B | Lysine-specific demethylase 5B. (1482 aa) |
| | NSUN5 | Putative methyltransferase NSUN5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (462 aa) |
| | BUD23 | Putative methyltransferase WBSCR22. (281 aa) |
| | LOC102279908 | Nicotinamide N-methyltransferase. (263 aa) |
| | NOP2 | Putative ribosomal RNA methyltransferase NOP2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (823 aa) |
| | KMT2E | Histone-lysine N-methyltransferase MLL5. (1846 aa) |
| | TRDMT1 | tRNA (Cytosine-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (391 aa) |
| | TRMT10A | RNA (Guanine-9-)-methyltransferase domain-containing protein 2. (338 aa) |
| | NSUN6 | Putative methyltransferase NSUN6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (470 aa) |
| | MRM3 | RNA methyltransferase-like protein 1. (413 aa) |
| | INMT | Indolethylamine N-methyltransferase. (278 aa) |
| | TFB2M | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (394 aa) |
| | METTL6 | Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (307 aa) |
| | TRMT44 | Putative tRNA (Uracil-O(2)-)-methyltransferase. (399 aa) |
| | JMJD6 | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6. (414 aa) |
| | DIMT1 | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (420 aa) |
