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| | NOP2 | Putative ribosomal RNA methyltransferase NOP2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (823 aa) |
| | TRDMT1 | tRNA (Cytosine-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (391 aa) |
| | NSUN6 | Putative methyltransferase NSUN6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (470 aa) |
| | RNMT | mRNA cap guanine-N7 methyltransferase. (477 aa) |
| | INMT | Indolethylamine N-methyltransferase. (278 aa) |
| | TFB2M | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (394 aa) |
| | DPH1 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (475 aa) |
| | DIMT1 | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (420 aa) |
| | NSD3 | Histone-lysine N-methyltransferase NSD3. (1439 aa) |
| | SETD7 | Histone-lysine N-methyltransferase SETD7. (384 aa) |
| | KMT2A | Histone-lysine N-methyltransferase MLL. (3957 aa) |
| | PCMT1 | Protein-L-isoaspartate O-methyltransferase. (285 aa) |
| | METTL1 | tRNA (guanine(46)-N(7))-methyltransferase. (277 aa) |
| | TRMT5 | tRNA (Guanine-N(1)-)-methyltransferase. (497 aa) |
| | NSUN2 | tRNA (Cytosine-5-)-methyltransferase NSUN2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (840 aa) |
| | BMT2 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa) |
| | TRMT12 | tRNA wybutosine-synthesizing protein 2-like protein. (462 aa) |
| | M91_10035 | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (239 aa) |
| | TFB1M | rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (339 aa) |
| | BCDIN3D | Putative methyltransferase BCDIN3D. (393 aa) |
| | SUV39H2 | Histone-lysine N-methyltransferase SUV39H2. (350 aa) |
| | ASMT | Hydroxyindole O-methyltransferase. (345 aa) |
| | M91_13497 | N-acetylserotonin O-methyltransferase-like protein. (238 aa) |
| | RSAD1 | Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (436 aa) |
| | TRMT1L | TRM1-like protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (737 aa) |
| | COQ5 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (330 aa) |
| | METTL11B | Uncharacterized protein. (283 aa) |
| | TRMT61A | tRNA (Adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A. (300 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1696 aa) |
| | LIAS | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa) |
| | MRM2 | Putative ribosomal RNA methyltransferase 2. (244 aa) |
| | NSUN4 | Putative methyltransferase NSUN4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (384 aa) |
| | PRMT5 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa) |
| | PRMT8 | Protein arginine N-methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (394 aa) |
| | PRMT2 | Protein arginine N-methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (434 aa) |
| | KMT2B | Histone-lysine N-methyltransferase MLL4. (2713 aa) |
| | AMD1 | S-adenosylmethionine decarboxylase proenzyme. (334 aa) |
| | NSUN7 | Putative methyltransferase NSUN7; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (722 aa) |
| | SETD2 | Histone-lysine N-methyltransferase SETD2. (2567 aa) |
| | NSUN3 | Putative methyltransferase NSUN3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (340 aa) |
| | TRMT1 | N(2),N(2)-dimethylguanosine tRNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (676 aa) |
| | DNMT3B | DNA (Cytosine-5)-methyltransferase 3B; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (856 aa) |
| | LOC102268256 | Histone-lysine N-methyltransferase SETMAR. (306 aa) |
| | M91_21227 | Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (363 aa) |
| | DOT1L | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1533 aa) |
| | KMT5A | Histone-lysine N-methyltransferase SETD8. (352 aa) |
| | DPH5 | Diphthine synthase. (285 aa) |
| | ASH1L | Putative histone-lysine N-methyltransferase ASH1L. (2965 aa) |
| | RRP8 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (460 aa) |
| | PRMT9 | TPR_REGION domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (844 aa) |
| | COQ3 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (370 aa) |
| | NTMT1 | Uncharacterized protein. (223 aa) |
| | ICMT | Protein-S-isoprenylcysteine O-methyltransferase. (188 aa) |
| | PRMT7 | Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (695 aa) |
| | PNMT | Phenylethanolamine N-methyltransferase. (367 aa) |
| | DPH2 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. (489 aa) |
| | PRMT6 | Protein arginine N-methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa) |
| | CARM1 | Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (614 aa) |
| | GAMT | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. (236 aa) |
| | SETD3 | Protein-histidine N-methyltransferase. (601 aa) |
| | PRMT1 | Protein arginine N-methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa) |
| | TRMT2A | tRNA (Uracil-5-)-methyltransferase-like protein A; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (628 aa) |
| | KMT5B | Histone-lysine N-methyltransferase SUV420H1. (883 aa) |
| | SUV39H1 | Histone-lysine N-methyltransferase SUV39H1. (414 aa) |
| | FTSJ1 | Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (329 aa) |
| | KMT2C | Histone-lysine N-methyltransferase MLL3. (4929 aa) |
| | CMTR2 | FtsJ methyltransferase domain-containing protein 1. (764 aa) |
| | FTSJ3 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (833 aa) |
| | DNMT3A | DNA (Cytosine-5)-methyltransferase 3A; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa) |
| | NSD1 | Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific. (2698 aa) |
| | NSUN5 | Putative methyltransferase NSUN5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (462 aa) |
| | LOC102279908 | Nicotinamide N-methyltransferase. (263 aa) |
