STRINGSTRING
MAP3K1 MAP3K1 LRRC31 LRRC31 MAPK11 MAPK11 RPS27A RPS27A KXD1 KXD1 UBA52 UBA52 MAPK15 MAPK15 ATF1 ATF1 MAPK7 MAPK7 LRRC14 LRRC14 IRAK1 IRAK1 NFKBIB NFKBIB ENSBMUP00000019167 ENSBMUP00000019167 RPS6KA4 RPS6KA4 UBB UBB PPP2R1B PPP2R1B DUSP7 DUSP7 TAB2 TAB2 ENSBMUP00000017506 ENSBMUP00000017506 M91_01211 M91_01211 LRRC71 LRRC71 SKP1-2 SKP1-2 HMGB1 HMGB1 MAP2K6 MAP2K6 AGER AGER USP18 USP18 TONSL TONSL ATF2 ATF2 TNIP2 TNIP2 APP APP TAB3 TAB3 MAP2K3 MAP2K3 M91_13196 M91_13196 ENSBMUP00000021670 ENSBMUP00000021670 N4BP1 N4BP1 RPS6KA1 RPS6KA1 PPP4R4 PPP4R4 NKIRAS2 NKIRAS2 MAP3K7 MAP3K7 PPP2CB PPP2CB ENSBMUP00000022382 ENSBMUP00000022382 CASP8 CASP8 PPP4R1 PPP4R1 RPS6KA3 RPS6KA3 S100B S100B FBXW11 FBXW11 CHUK CHUK RELCH RELCH DUSP6 DUSP6 LOC102274006 LOC102274006 UBC UBC ENSBMUP00000024784 ENSBMUP00000024784 DUSP3 DUSP3 CREB5 CREB5 NFKB1 NFKB1 MAPK8 MAPK8 MAPKAPK3 MAPKAPK3 PELI3 PELI3 LOC102267504 LOC102267504 LOC102267022 LOC102267022 NLRP9 NLRP9 VWC2 VWC2 NLRC5 NLRC5 TAB1 TAB1 IKBKB IKBKB MAP3K20 MAP3K20 ENSBMUP00000001281 ENSBMUP00000001281 MAPK1 MAPK1 SKP1 SKP1 PPP2CA PPP2CA NFKB2 NFKB2 RPS6KA2 RPS6KA2 ATF7 ATF7 ENSBMUP00000028583 ENSBMUP00000028583 S100A12 S100A12 NLRP6 NLRP6 MAPK10 MAPK10 LOC102276577 LOC102276577 PELI1 PELI1 USP14 USP14 PELI2 PELI2 IKBKG IKBKG FNBP4 FNBP4 LRRC45 LRRC45 MAPK3 MAPK3 ECSIT ECSIT ELK1 ELK1 MAP2K7 MAP2K7 ENSBMUP00000034660 ENSBMUP00000034660 NOD2 NOD2 LRRC74A LRRC74A MAPKAPK2 MAPKAPK2 TRAF2 TRAF2 RELA RELA LRRC34 LRRC34 MAPK14 MAPK14 PPP2R5D PPP2R5D FOSL2 FOSL2 MAP2K4 MAP2K4 ENSBMUP00000016464 ENSBMUP00000016464 NKIRAS1 NKIRAS1 MAPK9 MAPK9 RPS6KA5 RPS6KA5 TMEM189 TMEM189 IRAK2 IRAK2 LOC102278265 LOC102278265 RIPK2 RIPK2 NLRX1 NLRX1 CREB1 CREB1 MAP3K8 MAP3K8 TRAF6 TRAF6 JUN JUN KHNYN KHNYN DUSP4 DUSP4 CUL1 CUL1 FOS FOS NOD1 NOD1 UBE2N UBE2N LRRC74B LRRC74B VRK3 VRK3 NFKBIA NFKBIA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1509 aa)
LRRC31Leucine rich repeat containing 31. (555 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
RPS27AUbiquitin-small subunit ribosomal protein S27Ae. (156 aa)
KXD1KxDL domain-containing protein. (176 aa)
UBA52Ubiquitin-60S ribosomal protein L40. (128 aa)
MAPK15Mitogen-activated protein kinase 15. (575 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1. (412 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (782 aa)
LRRC14Leucine-rich repeat-containing protein 14. (493 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (640 aa)
NFKBIBNF-kappa-B inhibitor beta. (357 aa)
ENSBMUP00000019167annotation not available (102 aa)
RPS6KA4Ribosomal protein S6 kinase alpha-4. (773 aa)
UBBPolyubiquitin-C. (191 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (667 aa)
DUSP7Dual specificity protein phosphatase 7. (381 aa)
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 2. (409 aa)
ENSBMUP00000017506annotation not available (141 aa)
M91_01211TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa)
LRRC71Uncharacterized protein. (560 aa)
SKP1-2S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
HMGB1High mobility group protein B1. (215 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
AGERAdvanced glycosylation end-product specific receptor. (416 aa)
USP18Ubl carboxyl-terminal hydrolase 18. (321 aa)
TONSLNF-kappa-B inhibitor-like protein 2. (1373 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2. (505 aa)
TNIP2TNFAIP3 interacting protein 2. (256 aa)
APPAmyloid beta A4 protein. (652 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (717 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
M91_13196Uncharacterized protein. (663 aa)
ENSBMUP00000021670annotation not available (150 aa)
N4BP1NEDD4-binding protein 1. (861 aa)
RPS6KA1Ribosomal protein S6 kinase. (844 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (873 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2. (191 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PPP2CBSerine/threonine-protein phosphatase. (283 aa)
ENSBMUP00000022382Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like. (273 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (485 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (929 aa)
RPS6KA3Ribosomal protein S6 kinase alpha-3. (712 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
FBXW11F-box/WD repeat-containing protein 11. (531 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
RELCHLisH domain and HEAT repeat-containing protein KIAA1468. (1205 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
LOC102274006Serum amyloid A protein-like. (123 aa)
UBCPolyubiquitin-C. (305 aa)
ENSBMUP00000024784annotation not available (153 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (117 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (508 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAPKAPK3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
LOC102267504Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (131 aa)
LOC102267022Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (181 aa)
NLRP9NACHT, LRR and PYD domains-containing protein 9. (939 aa)
VWC2Brorin. (325 aa)
NLRC5Protein NLRC5. (1862 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (504 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase MLT. (800 aa)
ENSBMUP00000001281annotation not available (293 aa)
MAPK1Mitogen-activated protein kinase. (332 aa)
SKP1Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (161 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (900 aa)
RPS6KA2Ribosomal protein S6 kinase A2. (704 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7. (483 aa)
ENSBMUP00000028583annotation not available (70 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6. (877 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
LOC102276577Serum amyloid A protein-like. (131 aa)
PELI1Protein pellino-like protein 1. (418 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (494 aa)
PELI2Protein pellino-like protein 2. (420 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
FNBP4Formin-binding protein 4. (1004 aa)
LRRC45Leucine-rich repeat-containing protein 45. (666 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
ECSITEvolutionarily conserved signaling intermediate in Toll pathway, mitochondrial. (432 aa)
ELK1ETS domain-containing protein Elk-1. (440 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
ENSBMUP00000034660annotation not available (127 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
LRRC74AUncharacterized protein. (487 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TRAF2TNF receptor associated factor 2. (311 aa)
RELATranscription factor p65. (549 aa)
LRRC34Leucine-rich repeat-containing protein 34. (451 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform. (604 aa)
FOSL2Fos-related antigen 2. (313 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (410 aa)
ENSBMUP00000016464annotation not available (106 aa)
NKIRAS1NF-kappa-B inhibitor-interacting Ras-like protein 1. (192 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RPS6KA5Ribosomal protein S6 kinase alpha-5. (723 aa)
TMEM189Transmembrane protein 189. (193 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2. (621 aa)
LOC102278265Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (589 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (539 aa)
NLRX1NLR family member X1. (973 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (468 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
KHNYNProtein KHNYN. (676 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
CUL1Cullin-1; Belongs to the cullin family. (730 aa)
FOSProto-oncogene c-Fos. (380 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (954 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LRRC74BUncharacterized protein. (386 aa)
VRK3Serine/threonine-protein kinase VRK3. (451 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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