(57 nodes) DDX58/IFIH1-mediated induction of interferon-alpha/beta network (Bos mutus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102274006	Serum amyloid A protein-like. (123 aa)
	LOC102267022	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (181 aa)
	LOC102267504	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (131 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
	ENSBMUP00000001289	annotation not available (100 aa)
	RELA	Transcription factor p65. (549 aa)
	NFKB2	Nuclear factor NF-kappa-B p100 subunit. (900 aa)
	CREBBP	CREB-binding protein. (2203 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (224 aa)
	IRF3	Interferon regulatory factor 3. (417 aa)
	OTUD5	OTU domain-containing protein 5. (566 aa)
	SIKE1	Suppressor of IKK-epsilon. (209 aa)
	IRF7	Interferon regulatory factor 7. (481 aa)
	TOMM70	Mitochondrial import receptor subunit TOM70. (609 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3. (780 aa)
	RNF135	E3 ubiquitin-protein ligase RNF135. (431 aa)
	NLRX1	NLR family member X1. (973 aa)
	HSP90AB1	Heat shock protein HSP 90-beta. (722 aa)
	RNF125	E3 ubiquitin-protein ligase RNF125. (232 aa)
	NKIRAS1	NF-kappa-B inhibitor-interacting Ras-like protein 1. (192 aa)
	ENSBMUP00000017506	annotation not available (141 aa)
	UBB	Polyubiquitin-C. (191 aa)
	NFKBIB	NF-kappa-B inhibitor beta. (357 aa)
	LOC102279723	Heat shock protein 90 alpha family class A member 1. (119 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40. (128 aa)
	KXD1	KxDL domain-containing protein. (176 aa)
	RPS27A	Ubiquitin-small subunit ribosomal protein S27Ae. (156 aa)
	EP300	E1A binding protein p300. (2371 aa)
	DHX58	Putative ATP-dependent RNA helicase DHX58. (680 aa)
	NKIRAS2	NF-kappa-B inhibitor-interacting Ras-like protein 2. (191 aa)
	M91_10672	Heat shock protein HSP 90-beta. (124 aa)
	S100B	Protein S100; Belongs to the S-100 family. (92 aa)
	ENSBMUP00000022985	annotation not available (386 aa)
	HSP90AA1	Heat shock protein HSP 90-alpha. (664 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
	DDX58	Putative ATP-dependent RNA helicase DDX58. (942 aa)
	UBC	Polyubiquitin-C. (305 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit. (973 aa)
	UBE2L6	Ubiquitin/ISG15-conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (192 aa)
	TAX1BP1	Tax1-binding protein 1-like protein. (817 aa)
	HERC5	E3 ISG15--protein ligase HERC5. (1026 aa)
	MAVS	Mitochondrial antiviral-signaling protein. (510 aa)
	RNF216	E3 ubiquitin-protein ligase RNF216. (926 aa)
	UBA7	Ubiquitin-like modifier-activating enzyme 7. (1045 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	S100A12	Protein S100; Belongs to the S-100 family. (92 aa)
	LOC102276577	Serum amyloid A protein-like. (131 aa)
	VWC2	Brorin. (325 aa)
	HMGB1	High mobility group protein B1. (215 aa)
	AGER	Advanced glycosylation end-product specific receptor. (416 aa)
	TBK1	Serine/threonine-protein kinase TBK1. (875 aa)
	M91_14501	CARD_2 domain-containing protein. (75 aa)
	APP	Amyloid beta A4 protein. (652 aa)
	IKBKE	Inhibitor of nuclear factor kappa-B kinase subunit epsilon. (718 aa)
	ISG15	Ubiquitin-like protein ISG15. (170 aa)
	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD. (956 aa)
	IKBKG	NF-kappa-B essential modulator. (419 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	APP	ENSBMUP00000031592	ENSBMUP00000033831	Advanced glycosylation end-product specific receptor.	Amyloid beta A4 protein.	0.622
AGER	HMGB1	ENSBMUP00000031592	ENSBMUP00000030672	Advanced glycosylation end-product specific receptor.	High mobility group protein B1.	0.733
AGER	NFKB1	ENSBMUP00000031592	ENSBMUP00000026185	Advanced glycosylation end-product specific receptor.	Nuclear factor NF-kappa-B p105 subunit.	0.444
AGER	S100A12	ENSBMUP00000031592	ENSBMUP00000029016	Advanced glycosylation end-product specific receptor.	Protein S100; Belongs to the S-100 family.	0.765
AGER	S100B	ENSBMUP00000031592	ENSBMUP00000022980	Advanced glycosylation end-product specific receptor.	Protein S100; Belongs to the S-100 family.	0.948
APP	AGER	ENSBMUP00000033831	ENSBMUP00000031592	Amyloid beta A4 protein.	Advanced glycosylation end-product specific receptor.	0.622
APP	EP300	ENSBMUP00000033831	ENSBMUP00000021533	Amyloid beta A4 protein.	E1A binding protein p300.	0.416
APP	NFKB1	ENSBMUP00000033831	ENSBMUP00000026185	Amyloid beta A4 protein.	Nuclear factor NF-kappa-B p105 subunit.	0.509
APP	NFKB2	ENSBMUP00000033831	ENSBMUP00000002230	Amyloid beta A4 protein.	Nuclear factor NF-kappa-B p100 subunit.	0.443
APP	S100B	ENSBMUP00000033831	ENSBMUP00000022980	Amyloid beta A4 protein.	Protein S100; Belongs to the S-100 family.	0.515
CHUK	CREBBP	ENSBMUP00000023713	ENSBMUP00000003855	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	CREB-binding protein.	0.517
CHUK	CYLD	ENSBMUP00000023713	ENSBMUP00000034635	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Ubiquitin carboxyl-terminal hydrolase CYLD.	0.882
CHUK	ENSBMUP00000001289	ENSBMUP00000023713	ENSBMUP00000001289	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	annotation not available	0.409
CHUK	ENSBMUP00000017506	ENSBMUP00000023713	ENSBMUP00000017506	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	annotation not available	0.552
CHUK	ENSBMUP00000022985	ENSBMUP00000023713	ENSBMUP00000022985	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	annotation not available	0.403
CHUK	EP300	ENSBMUP00000023713	ENSBMUP00000021533	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	E1A binding protein p300.	0.404
CHUK	HSP90AA1	ENSBMUP00000023713	ENSBMUP00000023673	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Heat shock protein HSP 90-alpha.	0.409
CHUK	HSP90AB1	ENSBMUP00000023713	ENSBMUP00000015385	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Heat shock protein HSP 90-beta.	0.403
CHUK	IKBKB	ENSBMUP00000023713	ENSBMUP00000000951	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Inhibitor of nuclear factor kappa-B kinase subunit beta.	0.999
CHUK	IKBKE	ENSBMUP00000023713	ENSBMUP00000034106	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	0.473