(21 nodes) Processive synthesis on the C-strand of the telomere network (Bos mutus)

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Your Input:
	POLD4	DNA polymerase delta subunit 4. (178 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	TERF2	Telomeric repeat-binding factor 2. (540 aa)
	POLD3	DNA polymerase delta subunit 3. (464 aa)
	ACD	Adrenocortical dysplasia protein-like protein. (455 aa)
	LOC102276449	Replication protein A 32 kDa subunit. (270 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	RPA3	Replication protein A 14 kDa subunit. (121 aa)
	BLM	Bloom syndrome protein. (1430 aa)
	M91_12762	RPA_C domain-containing protein. (251 aa)
	POLD1	DNA polymerase delta 1, catalytic subunit. (1087 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	POT1	Protection of telomeres protein 1. (473 aa)
	LIG1	DNA ligase. (883 aa)
	RPA2	Replication protein A2. (270 aa)
	WRN	Werner syndrome ATP-dependent helicase. (1426 aa)
	TERF1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (438 aa)
	TERF2IP	Telomeric repeat-binding factor 2-interacting protein 1. (399 aa)
	DNA2	DNA replication ATP-dependent helicase Dna2. (1061 aa)
	TINF2	TERF1-interacting nuclear factor 2. (463 aa)
	POLD2	DNA polymerase delta subunit 2. (469 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	BLM	ENSBMUP00000004402	ENSBMUP00000009536	Adrenocortical dysplasia protein-like protein.	Bloom syndrome protein.	0.413
ACD	DNA2	ENSBMUP00000004402	ENSBMUP00000030448	Adrenocortical dysplasia protein-like protein.	DNA replication ATP-dependent helicase Dna2.	0.528
ACD	POT1	ENSBMUP00000004402	ENSBMUP00000022570	Adrenocortical dysplasia protein-like protein.	Protection of telomeres protein 1.	0.997
ACD	RPA1	ENSBMUP00000004402	ENSBMUP00000013619	Adrenocortical dysplasia protein-like protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.503
ACD	TERF1	ENSBMUP00000004402	ENSBMUP00000025319	Adrenocortical dysplasia protein-like protein.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.944
ACD	TERF2	ENSBMUP00000004402	ENSBMUP00000001761	Adrenocortical dysplasia protein-like protein.	Telomeric repeat-binding factor 2.	0.980
ACD	TERF2IP	ENSBMUP00000004402	ENSBMUP00000029199	Adrenocortical dysplasia protein-like protein.	Telomeric repeat-binding factor 2-interacting protein 1.	0.983
ACD	TINF2	ENSBMUP00000004402	ENSBMUP00000033472	Adrenocortical dysplasia protein-like protein.	TERF1-interacting nuclear factor 2.	0.997
ACD	WRN	ENSBMUP00000004402	ENSBMUP00000025020	Adrenocortical dysplasia protein-like protein.	Werner syndrome ATP-dependent helicase.	0.775
BLM	ACD	ENSBMUP00000009536	ENSBMUP00000004402	Bloom syndrome protein.	Adrenocortical dysplasia protein-like protein.	0.413
BLM	DNA2	ENSBMUP00000009536	ENSBMUP00000030448	Bloom syndrome protein.	DNA replication ATP-dependent helicase Dna2.	0.894
BLM	FEN1	ENSBMUP00000009536	ENSBMUP00000000319	Bloom syndrome protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.827
BLM	LIG1	ENSBMUP00000009536	ENSBMUP00000022708	Bloom syndrome protein.	DNA ligase.	0.481
BLM	LOC102276449	ENSBMUP00000009536	ENSBMUP00000005252	Bloom syndrome protein.	Replication protein A 32 kDa subunit.	0.966
BLM	M91_12762	ENSBMUP00000009536	ENSBMUP00000012105	Bloom syndrome protein.	RPA_C domain-containing protein.	0.680
BLM	PCNA	ENSBMUP00000009536	ENSBMUP00000006828	Bloom syndrome protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.744
BLM	POLD1	ENSBMUP00000009536	ENSBMUP00000012131	Bloom syndrome protein.	DNA polymerase delta 1, catalytic subunit.	0.709
BLM	POLD2	ENSBMUP00000009536	ENSBMUP00000035345	Bloom syndrome protein.	DNA polymerase delta subunit 2.	0.523
BLM	POLD3	ENSBMUP00000009536	ENSBMUP00000004105	Bloom syndrome protein.	DNA polymerase delta subunit 3.	0.671
BLM	POT1	ENSBMUP00000009536	ENSBMUP00000022570	Bloom syndrome protein.	Protection of telomeres protein 1.	0.592