STRINGSTRING
EGR1 EGR1 RPS6KA3 RPS6KA3 PPP4R1 PPP4R1 SHC3 SHC3 ENSBMUP00000022382 ENSBMUP00000022382 PPP2CB PPP2CB PPP4R4 PPP4R4 PIK3CA PIK3CA RPS6KA1 RPS6KA1 ENSBMUP00000021670 ENSBMUP00000021670 M91_13196 M91_13196 NTRK1 NTRK1 MAPK11 MAPK11 MAPK15 MAPK15 LYL1 LYL1 ATF1 ATF1 MAPK7 MAPK7 BRAF BRAF RHOA RHOA EGR3 EGR3 RIT1 RIT1 PPP2R1B PPP2R1B DUSP6 DUSP6 FRS2 FRS2 MAP2K2 MAP2K2 DUSP3 DUSP3 RALB RALB CRKL CRKL KRAS KRAS NKPD1 NKPD1 AP2M1 AP2M1 MAPKAPK3 MAPKAPK3 FOSB FOSB RPS6KA2 RPS6KA2 SHC4 SHC4 SH3GL2 SH3GL2 NAB1 NAB1 IRS1 IRS1 DUSP7 DUSP7 MAPK14 MAPK14 PPP2R5D PPP2R5D AP2B1 AP2B1 EGR2 EGR2 RPS6KA5 RPS6KA5 SHC1 SHC1 LOC102278265 LOC102278265 CREB1 CREB1 CRK CRK PIK3R1 PIK3R1 RAP1A RAP1A CHD4 CHD4 GRB2 GRB2 SGK1 SGK1 DUSP4 DUSP4 PIK3CB PIK3CB RPS6KA4 RPS6KA4 ID3 ID3 TRIB2 TRIB2 ELK1 ELK1 RELCH RELCH MAPK1 MAPK1 PPP2CA PPP2CA YWHAB YWHAB FOSL1 FOSL1 M91_18840 M91_18840 NGF NGF SHC2 SHC2 EGR4 EGR4 KIDINS220 KIDINS220 ID2 ID2 RALA RALA AP2A1 AP2A1 RRAD RRAD CLTC CLTC RALGDS RALGDS ERAS ERAS AP2S1 AP2S1 VRK3 VRK3 RAPGEF1 RAPGEF1 AP2A2 AP2A2 CSDE1 CSDE1 MAP2K1 MAP2K1 HRAS HRAS CLTA CLTA SOS1 SOS1 MAP2K5 MAP2K5 NRAS NRAS MAPK3 MAPK3 FNBP4 FNBP4 TRIB1 TRIB1 MAPKAPK2 MAPKAPK2 ENSBMUP00000034311 ENSBMUP00000034311 PIK3R2 PIK3R2 ENSBMUP00000034660 ENSBMUP00000034660 NAB2 NAB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGR1Early growth response protein 1. (540 aa)
RPS6KA3Ribosomal protein S6 kinase alpha-3. (712 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (929 aa)
SHC3SHC-transforming protein 3. (105 aa)
ENSBMUP00000022382Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like. (273 aa)
PPP2CBSerine/threonine-protein phosphatase. (283 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (873 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
RPS6KA1Ribosomal protein S6 kinase. (844 aa)
ENSBMUP00000021670annotation not available (150 aa)
M91_13196Uncharacterized protein. (663 aa)
NTRK1Tyrosine-protein kinase receptor. (799 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
MAPK15Mitogen-activated protein kinase 15. (575 aa)
LYL1Protein lyl-1. (281 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1. (412 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (782 aa)
BRAFSerine/threonine-protein kinase B-raf. (790 aa)
RHOATransforming protein RhoA. (193 aa)
EGR3Early growth response protein 3. (349 aa)
RIT1GTP-binding protein Rit1. (218 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (667 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (117 aa)
RALBRas-related protein Ral-B. (234 aa)
CRKLCrk-like protein. (302 aa)
KRASGTPase KRas. (189 aa)
NKPD1NTPase KAP family P-loop domain-containing protein 1. (559 aa)
AP2M1AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (459 aa)
MAPKAPK3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
FOSBProtein fosB. (341 aa)
RPS6KA2Ribosomal protein S6 kinase A2. (704 aa)
SHC4SHC-transforming protein 4. (630 aa)
SH3GL2Endophilin-A1. (317 aa)
NAB1NGFI-A-binding protein 1. (487 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
DUSP7Dual specificity protein phosphatase 7. (381 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform. (604 aa)
AP2B1AP-1 complex subunit beta-1. (951 aa)
EGR2Early growth response protein 2. (450 aa)
RPS6KA5Ribosomal protein S6 kinase alpha-5. (723 aa)
SHC1SHC-transforming protein 1. (501 aa)
LOC102278265Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (589 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
CRKAdapter molecule crk. (304 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
CHD4Chromodomain-helicase-DNA-binding protein 4. (1940 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
RPS6KA4Ribosomal protein S6 kinase alpha-4. (773 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
TRIB2Tribbles-like protein 2. (343 aa)
ELK1ETS domain-containing protein Elk-1. (440 aa)
RELCHLisH domain and HEAT repeat-containing protein KIAA1468. (1205 aa)
MAPK1Mitogen-activated protein kinase. (332 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (267 aa)
M91_18840Dynein light chain. (72 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (299 aa)
SHC2SHC adaptor protein 2. (450 aa)
EGR4Early growth response protein 4. (482 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa. (1710 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
RALARas-related protein Ral-A. (206 aa)
AP2A1AP-2 complex subunit alpha-1. (980 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (371 aa)
CLTCClathrin heavy chain 1. (1682 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (874 aa)
ERASGTPase ERas. (234 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (144 aa)
VRK3Serine/threonine-protein kinase VRK3. (451 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1265 aa)
AP2A2AP-2 complex subunit alpha-2. (934 aa)
CSDE1Cold shock domain containing E1. (839 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (393 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (243 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
NRASGTPase NRas. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
FNBP4Formin-binding protein 4. (1004 aa)
TRIB1Tribbles-like protein 1. (365 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ENSBMUP00000034311annotation not available (241 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ENSBMUP00000034660annotation not available (127 aa)
NAB2NGFI-A-binding protein 2. (524 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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