43 items (Bos mutus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VAV3	Guanine nucleotide exchange factor VAV3. (874 aa)
	GRAP2	GRB2-related adapter protein 2. (316 aa)
	ERAS	GTPase ERas. (234 aa)
	KLRG1	Killer cell lectin-like receptor subfamily G member 1. (190 aa)
	CSDE1	Cold shock domain containing E1. (839 aa)
	HRAS	HRas proto-oncogene, GTPase. (182 aa)
	SOS1	Son of sevenless-like protein 1. (1333 aa)
	NRAS	GTPase NRas. (189 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	LOC102276456	Killer cell lectin-like receptor subfamily D member 1. (175 aa)
	SIGLEC15	Sialic acid-binding Ig-like lectin 15. (175 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
	SYK	Non-specific protein-tyrosine kinase. (629 aa)
	ENSBMUP00000013283	annotation not available (116 aa)
	LOC102284891	Natural killer cells antigen CD94. (186 aa)
	SPNS3	Protein spinster-like protein 3. (543 aa)
	KLRK1	NKG2-D type II integral membrane protein. (215 aa)
	LOC102286014	C-type lectin domain-containing protein. (235 aa)
	M91_01485	C-type lectin domain-containing protein. (176 aa)
	LCP2	Lymphocyte cytosolic protein 2. (530 aa)
	SHC1	SHC-transforming protein 1. (501 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	RAC1	Ras-related C3 botulinum toxin substrate 1. (204 aa)
	LOC102276352	NKG2-A/NKG2-B type II integral membrane protein-like. (245 aa)
	PIK3CA	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	TYROBP	TYRO protein tyrosine kinase-binding protein. (158 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
	KRAS	GTPase KRas. (189 aa)
	PLCG2	Phosphoinositide phospholipase C. (1240 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (244 aa)
	TREM1	Triggering receptor expressed on myeloid cells 1. (232 aa)
	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
	RAC3	Rac family small GTPase 3. (208 aa)
	PLCG1	Phosphoinositide phospholipase C. (1277 aa)
	LCK	LCK proto-oncogene, Src family tyrosine kinase. (539 aa)
	VAV2	Guanine nucleotide exchange factor VAV2. (839 aa)
	LOC102272026	C-type lectin domain-containing protein. (227 aa)
	LOC102272599	C-type lectin domain-containing protein. (198 aa)
	SPNS1	Protein spinster-like protein 1. (526 aa)
	LAT	Linker for activation of T-cells family member 1. (280 aa)
	LOC102279719	NKG2-A/NKG2-B type II integral membrane protein. (243 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	LOC102276456	ENSBMUP00000025063	ENSBMUP00000012031	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Killer cell lectin-like receptor subfamily D member 1.	0.443
B2M	LOC102284891	ENSBMUP00000025063	ENSBMUP00000013653	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Natural killer cells antigen CD94.	0.453
BTK	FYN	ENSBMUP00000015075	ENSBMUP00000022504	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.509
BTK	GRAP2	ENSBMUP00000015075	ENSBMUP00000005209	Tyrosine-protein kinase.	GRB2-related adapter protein 2.	0.710
BTK	GRB2	ENSBMUP00000015075	ENSBMUP00000011430	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2.	0.795
BTK	LAT	ENSBMUP00000015075	ENSBMUP00000002309	Tyrosine-protein kinase.	Linker for activation of T-cells family member 1.	0.513
BTK	LCK	ENSBMUP00000015075	ENSBMUP00000011545	Tyrosine-protein kinase.	LCK proto-oncogene, Src family tyrosine kinase.	0.527
BTK	LCP2	ENSBMUP00000015075	ENSBMUP00000014746	Tyrosine-protein kinase.	Lymphocyte cytosolic protein 2.	0.980
BTK	PIK3CA	ENSBMUP00000015075	ENSBMUP00000022113	Tyrosine-protein kinase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family.	0.948
BTK	PIK3CB	ENSBMUP00000015075	ENSBMUP00000008705	Tyrosine-protein kinase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	0.939
BTK	PIK3R1	ENSBMUP00000015075	ENSBMUP00000012969	Tyrosine-protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.938
BTK	PIK3R2	ENSBMUP00000015075	ENSBMUP00000034582	Tyrosine-protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.932
BTK	PLCG1	ENSBMUP00000015075	ENSBMUP00000035654	Tyrosine-protein kinase.	Phosphoinositide phospholipase C.	0.970
BTK	PLCG2	ENSBMUP00000015075	ENSBMUP00000027485	Tyrosine-protein kinase.	Phosphoinositide phospholipase C.	0.992
BTK	SHC1	ENSBMUP00000015075	ENSBMUP00000014795	Tyrosine-protein kinase.	SHC-transforming protein 1.	0.612
BTK	SOS1	ENSBMUP00000015075	ENSBMUP00000007852	Tyrosine-protein kinase.	Son of sevenless-like protein 1.	0.483
BTK	SYK	ENSBMUP00000015075	ENSBMUP00000013152	Tyrosine-protein kinase.	Non-specific protein-tyrosine kinase.	0.975
BTK	TYROBP	ENSBMUP00000015075	ENSBMUP00000023612	Tyrosine-protein kinase.	TYRO protein tyrosine kinase-binding protein.	0.505
BTK	VAV2	ENSBMUP00000015075	ENSBMUP00000000931	Tyrosine-protein kinase.	Guanine nucleotide exchange factor VAV2.	0.709
BTK	VAV3	ENSBMUP00000015075	ENSBMUP00000003878	Tyrosine-protein kinase.	Guanine nucleotide exchange factor VAV3.	0.676