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LOC102267380 LOC102267380 NPR1 NPR1 KCNJ4 KCNJ4 ENSBMUP00000035353 ENSBMUP00000035353 SCN8A SCN8A CAMK2B CAMK2B KCNK18 KCNK18 KCNA5 KCNA5 CACNG4 CACNG4 CACNG5 CACNG5 MAST3 MAST3 ORAI3 ORAI3 FAHD2A FAHD2A KCNIP3 KCNIP3 CACNG7 CACNG7 ENSBMUP00000033219 ENSBMUP00000033219 CACNG6 CACNG6 KCNQ1 KCNQ1 NPR2 NPR2 KCNK16 KCNK16 KCNK17 KCNK17 KCNK5 KCNK5 FGF13 FGF13 LOC102280361 LOC102280361 KCNJ2 KCNJ2 LOC102286497 LOC102286497 MMEL1 MMEL1 M91_02303 M91_02303 ITPR2 ITPR2 RYR2 RYR2 RANGRF RANGRF ASPHD1 ASPHD1 KCNK2 KCNK2 LOC102281437 LOC102281437 ATP1B2 ATP1B2 ATP2A2 ATP2A2 CACNA2D2 CACNA2D2 ATP1B3 ATP1B3 ATP1B1 ATP1B1 TRPC1 TRPC1 PLN PLN ENSBMUP00000026846 ENSBMUP00000026846 TNNI3 TNNI3 FGF14 FGF14 ITPR3 ITPR3 DMPK DMPK LOC102284394 LOC102284394 PHEX PHEX PRKACA PRKACA KCNJ11 KCNJ11 MAST2 MAST2 ORAI1 ORAI1 CACNA2D1 CACNA2D1 SCN3B SCN3B ATP2B1 ATP2B1 SCN5A SCN5A NKX2-5 NKX2-5 SCN10A SCN10A SCN11A SCN11A M91_02713 M91_02713 LOC102267971 LOC102267971 M91_16044 M91_16044 KCNJ14 KCNJ14 LOC102287375 LOC102287375 ATP1A1 ATP1A1 RYR3 RYR3 KCNJ12 KCNJ12 ITPR1 ITPR1 M91_07106 M91_07106 LOC102286276 LOC102286276 ENSBMUP00000020727 ENSBMUP00000020727 MAST1 MAST1 KCNK4 KCNK4 KCNE5 KCNE5 SCN2A SCN2A CORIN CORIN SLC8A3 SLC8A3 CASQ1 CASQ1 ATP1A4 ATP1A4 ATP1A2 ATP1A2 FXYD4 FXYD4 RYR1 RYR1 NPPB NPPB NPPA NPPA FXYD2 FXYD2 CAMK2G CAMK2G FXYD6 FXYD6 NOS1 NOS1 SCN4B SCN4B SCN2B SCN2B CALM1 CALM1 ENSBMUP00000016200 ENSBMUP00000016200 CAMK2A CAMK2A MME MME ATP2A3 ATP2A3 CAMK2D CAMK2D CLIC2 CLIC2 LOC102273014 LOC102273014 KCNK10 KCNK10 MAST4 MAST4 SLN SLN KCND3 KCND3 CACNB2 CACNB2 KCNE2 KCNE2 SCN3A SCN3A SDR42E2 SDR42E2 CACNA1C-2 CACNA1C-2 KCNIP4 KCNIP4 ENSBMUP00000010833 ENSBMUP00000010833 KCNK3 KCNK3 ATP1A3 ATP1A3 ENSBMUP00000010141 ENSBMUP00000010141 LOC102275090 LOC102275090 SCN9A SCN9A ATP2B2 ATP2B2 SCN7A SCN7A ORAI2 ORAI2 M91_20811 M91_20811 KCNK1 KCNK1 ATP2B4 ATP2B4 SRI SRI FGF11 FGF11 SLC8A1 SLC8A1 SCN4A SCN4A STIM2 STIM2 FKBP1B FKBP1B CASQ2 CASQ2 FXYD5 FXYD5 ENSBMUP00000007588 ENSBMUP00000007588 FXYD1 FXYD1 ECEL1 ECEL1 FXYD3 FXYD3 SCN1B SCN1B M91_10145 M91_10145 ENSBMUP00000007011 ENSBMUP00000007011 CALM3 CALM3 KCNK12 KCNK12 KCNE4 KCNE4 CALM2 CALM2 LOC102285100 LOC102285100 KCND1 KCND1 ABCC9 ABCC9 KCNIP1 KCNIP1 SLC8A2 SLC8A2 ATP2B3 ATP2B3 KCNE3 KCNE3 AHCYL1 AHCYL1 KCNIP2 KCNIP2 FGF12 FGF12 CACNB1 CACNB1 M91_03796 M91_03796 ATP2A1 ATP2A1 KCNK7 KCNK7 KCNK6 KCNK6 ASPHD2 ASPHD2 KCNK9 KCNK9 NPPC NPPC STIM1 STIM1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LOC102267380Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
NPR1Guanylate cyclase. (1058 aa)
KCNJ4Inward rectifier potassium channel 4. (444 aa)
ENSBMUP00000035353annotation not available (127 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1988 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (645 aa)
KCNK18Potassium channel subfamily K member 18; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (385 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (565 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (266 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
MAST3Microtubule-associated serine/threonine-protein kinase 3. (1307 aa)
ORAI3Protein orai-3. (291 aa)
FAHD2AFumarylacetoacetate hydrolase domain-containing protein 2. (314 aa)
KCNIP3Calsenilin. (279 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
ENSBMUP00000033219annotation not available (218 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit. (260 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (676 aa)
NPR2Atrial natriuretic peptide receptor B. (1047 aa)
KCNK16Potassium channel subfamily K member 16; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (294 aa)
KCNK17Potassium channel subfamily K member. (329 aa)
KCNK5Potassium channel subfamily K member 5; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (497 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
LOC102280361Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
KCNJ2Inward rectifier potassium channel 2. (427 aa)
LOC102286497Potassium voltage-gated channel subfamily E member 1. (131 aa)
MMEL1Membrane metallo-endopeptidase-like 1. (758 aa)
M91_02303Uncharacterized protein. (93 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
RYR2Ryanodine receptor 2. (4951 aa)
RANGRFRan guanine nucleotide release factor. (186 aa)
ASPHD1Aspartate beta-hydroxylase domain-containing protein 1. (344 aa)
KCNK2Potassium channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
LOC102281437Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (285 aa)
ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2. (1037 aa)
CACNA2D2Voltage-dependent calcium channel subunit alpha-2/delta-2. (1153 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (88 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta. (303 aa)
TRPC1Short transient receptor putative channel 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
PLNPhospholamban. (52 aa)
ENSBMUP00000026846annotation not available (406 aa)
TNNI3Troponin I, cardiac muscle. (248 aa)
FGF14Fibroblast growth factor 14; Belongs to the heparin-binding growth factors family. (247 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2677 aa)
DMPKMyotonin-protein kinase. (593 aa)
LOC102284394Vomeronasal type-1 receptor. (305 aa)
PHEXPhosphate-regulating neutral endopeptidase. (749 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (349 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11. (388 aa)
MAST2Microtubule-associated serine/threonine-protein kinase 2. (1795 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (215 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1. (1103 aa)
SCN3BSodium channel subunit beta-3. (215 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2021 aa)
NKX2-5Homeobox protein Nkx-2.5. (323 aa)
SCN10ASodium voltage-gated channel alpha subunit 10. (1957 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1782 aa)
M91_02713Vomeronasal type-1 receptor. (309 aa)
LOC102267971Vomeronasal type-1 receptor. (304 aa)
M91_16044Vomeronasal type-1 receptor. (307 aa)
KCNJ14Potassium inwardly-rectifying channel subfamily J member 14. (430 aa)
LOC102287375Calmodulin. (149 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
RYR3Ryanodine receptor 3. (4877 aa)
KCNJ12ATP-sensitive inward rectifier potassium channel 12. (427 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
M91_07106Vomeronasal type-1 receptor. (327 aa)
LOC102286276Sodium channel protein type 1 subunit alpha-like. (406 aa)
ENSBMUP00000020727Sodium channel protein type 1 subunit alpha-like. (462 aa)
MAST1Microtubule associated serine/threonine kinase 1. (1561 aa)
KCNK4Potassium channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (274 aa)
KCNE5Potassium voltage-gated channel subfamily E member 1-like protein. (146 aa)
SCN2ASodium channel protein type 2 subunit alpha. (1584 aa)
CORINAtrial natriuretic peptide-converting enzyme. (1043 aa)
SLC8A3Sodium/calcium exchanger 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (395 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
FXYD4FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (88 aa)
RYR1Uncharacterized protein. (3719 aa)
NPPBUncharacterized protein. (129 aa)
NPPAAtrial natriuretic factor. (188 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (192 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (596 aa)
FXYD6FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (95 aa)
NOS1Nitric oxide synthase, brain. (1468 aa)
SCN4BSodium channel subunit beta-4. (228 aa)
SCN2BSodium channel subunit beta-2. (215 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
ENSBMUP00000016200annotation not available (98 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (489 aa)
MMENeprilysin. (750 aa)
ATP2A3Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1044 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta. (467 aa)
CLIC2Chloride intracellular channel protein 2. (247 aa)
LOC102273014Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (234 aa)
KCNK10Potassium channel subfamily K member 10; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (487 aa)
MAST4Microtubule-associated serine/threonine-protein kinase 4. (3024 aa)
SLNSarcolipin. (31 aa)
KCND3Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (655 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2. (658 aa)
KCNE2Potassium voltage-gated channel subfamily E member 2. (123 aa)
SCN3ASodium channel protein type 3 subunit alpha. (1978 aa)
SDR42E2Putative short-chain dehydrogenase/reductase family 42E member 2; Belongs to the 3-beta-HSD family. (413 aa)
CACNA1C-2Voltage-dependent calcium channel L type alpha-1C. (1249 aa)
KCNIP4Kv channel-interacting protein 4. (250 aa)
ENSBMUP00000010833annotation not available (119 aa)
KCNK3Potassium channel subfamily K member 3; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (398 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1014 aa)
ENSBMUP00000010141annotation not available (192 aa)
LOC102275090Sodium channel protein type 1 subunit alpha. (1125 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1986 aa)
ATP2B2Plasma membrane calcium-transporting ATPase 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1246 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1677 aa)
ORAI2Protein orai-2. (254 aa)
M91_20811Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
KCNK1Potassium channel subfamily K member 1; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (336 aa)
ATP2B4Plasma membrane calcium-transporting ATPase 4; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1207 aa)
SRISorcin. (199 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
SLC8A1Sodium/calcium exchanger 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1834 aa)
STIM2Stromal interaction molecule 2. (754 aa)
FKBP1BPeptidylprolyl isomerase. (184 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (431 aa)
FXYD5FXYD domain containing ion transport regulator 5. (173 aa)
ENSBMUP00000007588annotation not available (134 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (203 aa)
ECEL1Endothelin converting enzyme like 1. (775 aa)
FXYD3FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (88 aa)
SCN1BSodium channel subunit beta-1. (207 aa)
M91_10145Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
ENSBMUP00000007011annotation not available (107 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (159 aa)
KCNK12Potassium channel subfamily K member 12; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (381 aa)
KCNE4Potassium voltage-gated channel subfamily E member 4. (168 aa)
CALM2Calmodulin 2. (194 aa)
LOC102285100Aspartyl/asparaginyl beta-hydroxylase. (206 aa)
KCND1Potassium voltage-gated channel subfamily D member 1; Belongs to the potassium channel family. (648 aa)
ABCC9ATP-binding cassette sub-family C member 9. (1549 aa)
KCNIP1Kv channel-interacting protein 1. (207 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (889 aa)
ATP2B3Plasma membrane calcium-transporting ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1220 aa)
KCNE3Potassium voltage-gated channel subfamily E member 3. (99 aa)
AHCYL1Adenosylhomocysteinase. (530 aa)
KCNIP2Kv channel-interacting protein 2. (270 aa)
FGF12Fibroblast growth factor 11/12/13. (243 aa)
CACNB1Voltage-dependent L-type calcium channel subunit beta-1. (643 aa)
M91_03796Uncharacterized protein. (135 aa)
ATP2A1Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (997 aa)
KCNK7Potassium channel subfamily K member. (307 aa)
KCNK6Potassium channel subfamily K member. (301 aa)
ASPHD2Aspartate beta-hydroxylase domain-containing protein 2. (369 aa)
KCNK9Potassium channel subfamily K member 9; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (340 aa)
NPPCC-type natriuretic peptide. (126 aa)
STIM1Stromal interaction molecule 1. (790 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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