STRINGSTRING
GAB1 GAB1 FGF8 FGF8 FGF17 FGF17 FGF2 FGF2 FGFR2 FGFR2 PIK3CA PIK3CA FGF16 FGF16 FRS2 FRS2 FGF5 FGF5 ERAS ERAS CSDE1 CSDE1 HRAS HRAS SOS1 SOS1 NRAS NRAS GRB2 GRB2 FGF7 FGF7 KRAS KRAS FGF9 FGF9 PTPN11 PTPN11 FGF1 FGF1 PIK3R1 PIK3R1 SHC1 SHC1 FGF10 FGF10 FRS3 FRS3 FGF6 FGF6 FGF20 FGF20 M91_10940 M91_10940 FGF22 FGF22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAB1GRB2-associated-binding protein 1. (724 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (125 aa)
ERASGTPase ERas. (234 aa)
CSDE1Cold shock domain containing E1. (839 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
NRASGTPase NRas. (189 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
FGF7Fibroblast growth factor 7. (194 aa)
KRASGTPase KRas. (189 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (593 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (195 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
SHC1SHC-transforming protein 1. (501 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FRS3Fibroblast growth factor receptor substrate 3. (489 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
M91_10940Tyrosine-protein phosphatase non-receptor type 11. (618 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (310 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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