STRINGSTRING
FGF18 FGF18 SHC1 SHC1 PIK3R1 PIK3R1 PTPN11 PTPN11 GRB2 GRB2 FGFR4 FGFR4 NRAS NRAS SOS1 SOS1 FGF2 FGF2 PIK3CA PIK3CA FGF16 FGF16 FRS2 FRS2 FGF1 FGF1 FGF9 FGF9 KLB KLB KRAS KRAS FRS3 FRS3 FGF20 FGF20 M91_10940 M91_10940 FGF6 FGF6 PLCG1 PLCG1 HRAS HRAS FGF3 FGF3 CSDE1 CSDE1 ERAS ERAS GAB1 GAB1 FGF8 FGF8 FGF17 FGF17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SHC1SHC-transforming protein 1. (501 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (593 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
FGFR4Fibroblast growth factor receptor. (799 aa)
NRASGTPase NRas. (189 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (195 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
KLBBeta-klotho. (1016 aa)
KRASGTPase KRas. (189 aa)
FRS3Fibroblast growth factor receptor substrate 3. (489 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
M91_10940Tyrosine-protein phosphatase non-receptor type 11. (618 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PLCG1Phosphoinositide phospholipase C. (1277 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
CSDE1Cold shock domain containing E1. (839 aa)
ERASGTPase ERas. (234 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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