STRINGSTRING
NRAS NRAS GRB2 GRB2 PTPN11 PTPN11 PIK3R1 PIK3R1 CBL CBL SHC1 SHC1 FGF17 FGF17 ENSBMUP00000017506 ENSBMUP00000017506 MKNK2 MKNK2 UBB UBB FGF2 FGF2 CSDE1 CSDE1 ERAS ERAS MAPK1 MAPK1 FGF8 FGF8 PPP2CA PPP2CA FNDC3A FNDC3A GAB1 GAB1 SRC SRC FNDC3B FNDC3B HRAS HRAS SOS1 SOS1 MAPK3 MAPK3 ENSBMUP00000034660 ENSBMUP00000034660 M91_10940 M91_10940 FGF20 FGF20 FRS3 FRS3 FGFR3 FGFR3 KRAS KRAS FGF9 FGF9 FGF1 FGF1 MKNK1 MKNK1 FGF5 FGF5 FRS2 FRS2 UBC UBC FGF16 FGF16 LOC102280173 LOC102280173 ENSBMUP00000022382 ENSBMUP00000022382 PPP2CB PPP2CB SPRY2 SPRY2 PIK3CA PIK3CA RPS27A RPS27A GALNT3 GALNT3 UBA52 UBA52 BRAF BRAF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRASGTPase NRas. (189 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (593 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
CBLE3 ubiquitin-protein ligase CBL. (906 aa)
SHC1SHC-transforming protein 1. (501 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ENSBMUP00000017506annotation not available (141 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2; Belongs to the protein kinase superfamily. (464 aa)
UBBPolyubiquitin-C. (191 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
CSDE1Cold shock domain containing E1. (839 aa)
ERASGTPase ERas. (234 aa)
MAPK1Mitogen-activated protein kinase. (332 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
FNDC3AFibronectin type-III domain-containing protein 3A. (1198 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
SRCTyrosine-protein kinase. (559 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1207 aa)
HRASHRas proto-oncogene, GTPase. (182 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
ENSBMUP00000034660annotation not available (127 aa)
M91_10940Tyrosine-protein phosphatase non-receptor type 11. (618 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FRS3Fibroblast growth factor receptor substrate 3. (489 aa)
FGFR3Fibroblast growth factor receptor 3. (788 aa)
KRASGTPase KRas. (189 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (195 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (426 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (125 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
UBCPolyubiquitin-C. (305 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC102280173Fibronectin type III domain containing protein 3C1-like. (1297 aa)
ENSBMUP00000022382Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like. (273 aa)
PPP2CBSerine/threonine-protein phosphatase. (283 aa)
SPRY2Protein sprouty-like protein 2. (315 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
RPS27AUbiquitin-small subunit ribosomal protein S27Ae. (156 aa)
GALNT3Polypeptide N-acetylgalactosaminyltransferase. (633 aa)
UBA52Ubiquitin-60S ribosomal protein L40. (128 aa)
BRAFSerine/threonine-protein kinase B-raf. (790 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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