(68 nodes) NIK-->noncanonical NF-kB signaling network (Bos mutus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PSMC2	26S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
	PSMC1	26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
	ENSBMUP00000017506	annotation not available (141 aa)
	UBB	Polyubiquitin-C. (191 aa)
	ENSBMUP00000019167	annotation not available (102 aa)
	PSME3	Proteasome activator subunit 3. (270 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40. (128 aa)
	KXD1	KxDL domain-containing protein. (176 aa)
	PSMC4	26S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
	RPS27A	Ubiquitin-small subunit ribosomal protein S27Ae. (156 aa)
	SKP1-2	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
	PSMD5	26S proteasome non-ATPase regulatory subunit 5. (504 aa)
	PSMF1	Proteasome inhibitor PI31 subunit. (270 aa)
	PSMA8	Proteasome subunit alpha type. (250 aa)
	PSMD14	26S proteasome non-ATPase regulatory subunit 14. (310 aa)
	FBXW11	F-box/WD repeat-containing protein 11. (531 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
	PSMD9	26S proteasome non-ATPase regulatory subunit 9. (221 aa)
	UBC	Polyubiquitin-C. (305 aa)
	PSMB11	Proteasome subunit beta. (289 aa)
	PSMB5	Proteasome subunit beta. (263 aa)
	ENSBMUP00000024784	annotation not available (153 aa)
	ENSBMUP00000025864	annotation not available (174 aa)
	PSMD2	26S proteasome non-ATPase regulatory subunit 2. (908 aa)
	RELB-2	RELB proto-oncogene, NF-kB subunit. (101 aa)
	RELB	RELB proto-oncogene, NF-kB subunit. (503 aa)
	PSMB7	Proteasome subunit beta. (277 aa)
	PSMD10	26S proteasome non-ATPase regulatory subunit 10. (269 aa)
	ENSBMUP00000028583	annotation not available (70 aa)
	PSMB2	Proteasome subunit beta. (201 aa)
	UBE2M	NEDD8-conjugating enzyme Ubc12; Belongs to the ubiquitin-conjugating enzyme family. (180 aa)
	PSMD13	26S proteasome non-ATPase regulatory subunit 13. (376 aa)
	PSME4	Proteasome activator subunit 4. (1843 aa)
	PSMA7	20S proteasome subunit alpha 4. (178 aa)
	PSMD4	26S proteasome regulatory subunit N10. (377 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
	PSMC3	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (440 aa)
	PSME1	Proteasome activator complex subunit 1. (249 aa)
	PSME2	Proteasome activator complex subunit 2. (253 aa)
	PSMA1	Proteasome subunit alpha type. (269 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1. (953 aa)
	PSMB1	Proteasome subunit beta. (241 aa)
	PSMA2	Proteasome endopeptidase complex. (234 aa)
	ENSBMUP00000001195	annotation not available (156 aa)
	PSMD8	26S proteasome non-ATPase regulatory subunit 8. (287 aa)
	PSMD7	26S proteasome regulatory subunit N8. (319 aa)
	PSMB3	Proteasome subunit beta. (205 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (953 aa)
	PSMA3	Proteasome subunit alpha type. (255 aa)
	NFKB2	Nuclear factor NF-kappa-B p100 subunit. (900 aa)
	SKP1	Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (161 aa)
	PSMB10	Proteasome subunit beta. (273 aa)
	BTRC	F-box/WD repeat-containing protein 1A. (605 aa)
	PSMD3	26S proteasome non-ATPase regulatory subunit 3. (534 aa)
	PSMA6	Proteasome subunit alpha type. (246 aa)
	PSMA5	Proteasome endopeptidase complex. (241 aa)
	PSMA4	Proteasome subunit alpha type. (261 aa)
	PSMC6	26S proteasome regulatory subunit T4. (403 aa)
	ENSBMUP00000005622	annotation not available (197 aa)
	PSMB6	Proteasome subunit beta. (335 aa)
	PSMC5	26S protease regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
	CUL1	Cullin-1; Belongs to the cullin family. (730 aa)
	PSMB8	Proteasome subunit beta. (276 aa)
	PSMB9	Proteasome subunit beta. (219 aa)
	PSMD12	26S proteasome non-ATPase regulatory subunit 12. (456 aa)
	M91_07947	Proteasome endopeptidase complex. (163 aa)
	PSMD11	26S proteasome non-ATPase regulatory subunit 11. (422 aa)
	UBA3	NEDD8-activating enzyme E1 catalytic subunit. (442 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTRC	CHUK	ENSBMUP00000003782	ENSBMUP00000023713	F-box/WD repeat-containing protein 1A.	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	0.602
BTRC	CUL1	ENSBMUP00000003782	ENSBMUP00000009829	F-box/WD repeat-containing protein 1A.	Cullin-1; Belongs to the cullin family.	0.989
BTRC	ENSBMUP00000017506	ENSBMUP00000003782	ENSBMUP00000017506	F-box/WD repeat-containing protein 1A.	annotation not available	0.660
BTRC	ENSBMUP00000019167	ENSBMUP00000003782	ENSBMUP00000019167	F-box/WD repeat-containing protein 1A.	annotation not available	0.844
BTRC	ENSBMUP00000024784	ENSBMUP00000003782	ENSBMUP00000024784	F-box/WD repeat-containing protein 1A.	annotation not available	0.844
BTRC	ENSBMUP00000028583	ENSBMUP00000003782	ENSBMUP00000028583	F-box/WD repeat-containing protein 1A.	annotation not available	0.879
BTRC	FBXW11	ENSBMUP00000003782	ENSBMUP00000023621	F-box/WD repeat-containing protein 1A.	F-box/WD repeat-containing protein 11.	0.972
BTRC	NFKB2	ENSBMUP00000003782	ENSBMUP00000002230	F-box/WD repeat-containing protein 1A.	Nuclear factor NF-kappa-B p100 subunit.	0.742
BTRC	RPS27A	ENSBMUP00000003782	ENSBMUP00000020797	F-box/WD repeat-containing protein 1A.	Ubiquitin-small subunit ribosomal protein S27Ae.	0.708
BTRC	SKP1	ENSBMUP00000003782	ENSBMUP00000002792	F-box/WD repeat-containing protein 1A.	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.844
BTRC	SKP1-2	ENSBMUP00000003782	ENSBMUP00000021338	F-box/WD repeat-containing protein 1A.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.983
BTRC	UBA3	ENSBMUP00000003782	ENSBMUP00000015027	F-box/WD repeat-containing protein 1A.	NEDD8-activating enzyme E1 catalytic subunit.	0.548
BTRC	UBA52	ENSBMUP00000003782	ENSBMUP00000020581	F-box/WD repeat-containing protein 1A.	Ubiquitin-60S ribosomal protein L40.	0.723
BTRC	UBB	ENSBMUP00000003782	ENSBMUP00000018689	F-box/WD repeat-containing protein 1A.	Polyubiquitin-C.	0.658
BTRC	UBC	ENSBMUP00000003782	ENSBMUP00000024192	F-box/WD repeat-containing protein 1A.	Polyubiquitin-C.	0.658
CHUK	BTRC	ENSBMUP00000023713	ENSBMUP00000003782	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	F-box/WD repeat-containing protein 1A.	0.602
CHUK	CUL1	ENSBMUP00000023713	ENSBMUP00000009829	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	Cullin-1; Belongs to the cullin family.	0.472
CHUK	ENSBMUP00000017506	ENSBMUP00000023713	ENSBMUP00000017506	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	annotation not available	0.552
CHUK	ENSBMUP00000028583	ENSBMUP00000023713	ENSBMUP00000028583	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	annotation not available	0.455
CHUK	FBXW11	ENSBMUP00000023713	ENSBMUP00000023621	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	F-box/WD repeat-containing protein 11.	0.569