STRINGSTRING
LOC106700690 LOC106700690 LOC102277470 LOC102277470 M91_18177 M91_18177 H2BC6 H2BC6 ENSBMUP00000000556 ENSBMUP00000000556 LOC102278316 LOC102278316 LOC102284726 LOC102284726 LOC102279439 LOC102279439 LOC102281510-2 LOC102281510-2 H2BC3 H2BC3 ENSBMUP00000001049 ENSBMUP00000001049 LOC102280286 LOC102280286 MUS81 MUS81 RAD51 RAD51 KAT5 KAT5 H2BC21 H2BC21 ENSBMUP00000001813 ENSBMUP00000001813 ENSBMUP00000001828 ENSBMUP00000001828 LOC102279902 LOC102279902 H2BC18 H2BC18 RCBTB2 RCBTB2 SLX4 SLX4 RCBTB1 RCBTB1 LOC102282010 LOC102282010 LOC102275563 LOC102275563 ENSBMUP00000002785 ENSBMUP00000002785 M91_04770 M91_04770 LOC106700742 LOC106700742 ENSBMUP00000003566 ENSBMUP00000003566 RAD1 RAD1 ENSBMUP00000004078 ENSBMUP00000004078 POLD3 POLD3 RNF169 RNF169 LOC106701130 LOC106701130 M91_01803 M91_01803 M91_12053 M91_12053 ENSBMUP00000005059 ENSBMUP00000005059 ENSBMUP00000005170 ENSBMUP00000005170 ENSBMUP00000005244 ENSBMUP00000005244 LOC102276449 LOC102276449 LOC102265229 LOC102265229 ABRAXAS1 ABRAXAS1 ENSBMUP00000005397 ENSBMUP00000005397 ENSBMUP00000005719 ENSBMUP00000005719 MRE11 MRE11 ENSBMUP00000005800 ENSBMUP00000005800 ENSBMUP00000006078 ENSBMUP00000006078 LOC102276058 LOC102276058 ENSBMUP00000006237 ENSBMUP00000006237 ENSBMUP00000006401 ENSBMUP00000006401 LOC106701387 LOC106701387 ENSBMUP00000006455 ENSBMUP00000006455 M91_00299 M91_00299 PCNA PCNA BRIP1 BRIP1 TOPBP1 TOPBP1 ENSBMUP00000007008 ENSBMUP00000007008 ENSBMUP00000007124 ENSBMUP00000007124 LOC102284155 LOC102284155 ENSBMUP00000007365 ENSBMUP00000007365 LOC102282737 LOC102282737 XRCC2 XRCC2 TIPIN TIPIN ENSBMUP00000007581 ENSBMUP00000007581 ABL1 ABL1 UBE2N UBE2N HUS1 HUS1 RPA3 RPA3 LOC102280785 LOC102280785 ENSBMUP00000008758 ENSBMUP00000008758 ENSBMUP00000009019 ENSBMUP00000009019 BRCC3 BRCC3 ENSBMUP00000009190 ENSBMUP00000009190 H2BC15 H2BC15 LOC102270329 LOC102270329 M91_14726 M91_14726 LOC102271941 LOC102271941 RMI1 RMI1 BLM BLM M91_19792 M91_19792 MDC1 MDC1 ENSBMUP00000009984 ENSBMUP00000009984 ENSBMUP00000010118 ENSBMUP00000010118 LOC102284118 LOC102284118 RAD52 RAD52 LOC102274943 LOC102274943 SUMO2 SUMO2 LOC102266324 LOC102266324 ENSBMUP00000011755 ENSBMUP00000011755 M91_12762 M91_12762 POLD1 POLD1 M91_13835 M91_13835 CDK3 CDK3 ENSBMUP00000013457 ENSBMUP00000013457 RPA1 RPA1 NBN NBN ENSBMUP00000013748 ENSBMUP00000013748 M91_08851 M91_08851 SLF1 SLF1 RFC2 RFC2 SPIDR SPIDR HERC2 HERC2 ENSBMUP00000015274 ENSBMUP00000015274 POLK POLK LOC102277538 LOC102277538 ATRIP ATRIP ENSBMUP00000015761 ENSBMUP00000015761 POLH POLH ENSBMUP00000015985 ENSBMUP00000015985 LOC106700675 LOC106700675 ENSBMUP00000016303 ENSBMUP00000016303 ENSBMUP00000016432 ENSBMUP00000016432 RFC5 RFC5 ENSBMUP00000016464 ENSBMUP00000016464 M91_02342 M91_02342 RAD51B RAD51B ANKRD11 ANKRD11 BABAM2 BABAM2 EXD2 EXD2 RAD51D RAD51D ENSBMUP00000017506 ENSBMUP00000017506 ENSBMUP00000017560 ENSBMUP00000017560 POLE4 POLE4 BRCA2 BRCA2 CCNA1 CCNA1 ENSBMUP00000018262 ENSBMUP00000018262 RFC3 RFC3 ENSBMUP00000018430 ENSBMUP00000018430 ENSBMUP00000018435 ENSBMUP00000018435 ENSBMUP00000018439 ENSBMUP00000018439 UBB UBB LOC102275363 LOC102275363 M91_00314 M91_00314 RAD50 RAD50 ENSBMUP00000019601 ENSBMUP00000019601 RECQL4 RECQL4 GEN1 GEN1 EXO1 EXO1 ENSBMUP00000020374 ENSBMUP00000020374 M91_12052 M91_12052 UBA52 UBA52 KXD1 KXD1 TOP3A TOP3A RPS27A RPS27A ENSBMUP00000021057 ENSBMUP00000021057 ENSBMUP00000021139 ENSBMUP00000021139 RNF8 RNF8 M91_12051 M91_12051 ENSBMUP00000022134 ENSBMUP00000022134 H2BU1 H2BU1 ENSBMUP00000022649 ENSBMUP00000022649 LOC102276664 LOC102276664 RPA2 RPA2 CDK2 CDK2 RFC4 RFC4 MEIOB MEIOB RHNO1 RHNO1 ENSBMUP00000024154 ENSBMUP00000024154 UBC UBC EME2 EME2 TIMELESS TIMELESS LOC102287406 LOC102287406 ENSBMUP00000024507 ENSBMUP00000024507 UIMC1 UIMC1 M91_20283 M91_20283 PIAS4 PIAS4 SIRT6 SIRT6 WRN WRN M91_19011 M91_19011 M91_01313 M91_01313 RFC1 RFC1 ENSBMUP00000026207 ENSBMUP00000026207 ENSBMUP00000026335 ENSBMUP00000026335 M91_08832 M91_08832 NSD2 NSD2 BRCA1 BRCA1 TP53BP1 TP53BP1 ERCC1 ERCC1 ATR ATR BABAM1 BABAM1 ENSBMUP00000027767 ENSBMUP00000027767 M91_18749 M91_18749 RAD9B RAD9B RAD51C RAD51C LOC102274007 LOC102274007 RNF168 RNF168 M91_06432 M91_06432 RAD9A RAD9A ENSBMUP00000028691 ENSBMUP00000028691 POLE2 POLE2 LOC102268935 LOC102268935 XRCC3 XRCC3 ENSBMUP00000028984 ENSBMUP00000028984 ERCC4 ERCC4 RBBP8 RBBP8 ENSBMUP00000029324 ENSBMUP00000029324 POLE POLE EME1 EME1 M91_05906 M91_05906 ENSBMUP00000029868 ENSBMUP00000029868 LOC102264829 LOC102264829 M91_19001 M91_19001 BARD1 BARD1 PALB2 PALB2 UBE2I UBE2I POLD4 POLD4 M91_01403 M91_01403 LOC102286916 LOC102286916 SIRT7 SIRT7 ENSBMUP00000035452 ENSBMUP00000035452 LOC102273005 LOC102273005 SLX1A SLX1A PPP4C PPP4C POLD2 POLD2 ENSBMUP00000034914 ENSBMUP00000034914 RAD51AP1 RAD51AP1 ENSBMUP00000033781 ENSBMUP00000033781 LOC102277056 LOC102277056 ENSBMUP00000033482 ENSBMUP00000033482 ENSBMUP00000033262 ENSBMUP00000033262 ENSBMUP00000033156 ENSBMUP00000033156 M91_15771 M91_15771 ENSBMUP00000032770 ENSBMUP00000032770 ENSBMUP00000032747 ENSBMUP00000032747 H2BC11 H2BC11 ENSBMUP00000032671 ENSBMUP00000032671 ENSBMUP00000032580 ENSBMUP00000032580 ENSBMUP00000032340 ENSBMUP00000032340 TDRD3 TDRD3 RAD17 RAD17 ENSBMUP00000032035 ENSBMUP00000032035 M91_16901 M91_16901 ENSBMUP00000031804 ENSBMUP00000031804 LOC102279735 LOC102279735 LOC102282517 LOC102282517 POLE3 POLE3 M91_15717 M91_15717 M91_01445 M91_01445 LOC102266500 LOC102266500 PPP4R2 PPP4R2 DNA2 DNA2 CCNA2 CCNA2 ENSBMUP00000000061 ENSBMUP00000000061 ENSBMUP00000000180 ENSBMUP00000000180 M91_11360 M91_11360 LOC102276351 LOC102276351 LOC102281510 LOC102281510 ENSBMUP00000000321 ENSBMUP00000000321 ENSBMUP00000000337 ENSBMUP00000000337 LOC102277188 LOC102277188 ENSBMUP00000000398 ENSBMUP00000000398
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC106700690Histone H4. (103 aa)
LOC102277470Histone H2B; Belongs to the histone H2B family. (126 aa)
M91_18177Histone domain-containing protein; Belongs to the histone H2B family. (124 aa)
H2BC6Histone H2B type 1. (126 aa)
ENSBMUP00000000556annotation not available (103 aa)
LOC102278316Histone H2B type 1. (126 aa)
LOC102284726Histone H4. (103 aa)
LOC102279439Histone H2B type 1-H; Belongs to the histone H2B family. (126 aa)
LOC102281510-2Histone H4. (103 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSBMUP00000001049annotation not available (103 aa)
LOC102280286Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
MUS81Crossover junction endonuclease MUS81. (583 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSBMUP00000001813annotation not available (164 aa)
ENSBMUP00000001828annotation not available (156 aa)
LOC102279902Histone H4. (103 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (132 aa)
RCBTB2RCC1 and BTB domain-containing protein 2. (554 aa)
SLX4Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12). (1789 aa)
RCBTB1RCC1 and BTB domain-containing protein 1. (531 aa)
LOC102282010Histone H4. (103 aa)
LOC102275563Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSBMUP00000002785annotation not available (105 aa)
M91_04770Uncharacterized protein. (625 aa)
LOC106700742Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
ENSBMUP00000003566Histone H2B type 2-E-like. (126 aa)
RAD1Cell cycle checkpoint protein RAD1. (279 aa)
ENSBMUP00000004078annotation not available (108 aa)
POLD3DNA polymerase delta subunit 3. (464 aa)
RNF169RING finger protein 169. (708 aa)
LOC106701130Uncharacterized protein; Belongs to the histone H2B family. (128 aa)
M91_01803Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
M91_12053Uncharacterized protein. (622 aa)
ENSBMUP00000005059annotation not available (173 aa)
ENSBMUP00000005170annotation not available (424 aa)
ENSBMUP00000005244annotation not available (429 aa)
LOC102276449Replication protein A 32 kDa subunit. (270 aa)
LOC102265229Histone H4. (103 aa)
ABRAXAS1BRCA1-A complex subunit Abraxas. (428 aa)
ENSBMUP00000005397annotation not available (91 aa)
ENSBMUP00000005719annotation not available (310 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
ENSBMUP00000005800annotation not available (173 aa)
ENSBMUP00000006078annotation not available (49 aa)
LOC102276058Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSBMUP00000006237annotation not available (131 aa)
ENSBMUP00000006401annotation not available (91 aa)
LOC106701387Histone H2B type 2-E; Belongs to the histone H2B family. (126 aa)
ENSBMUP00000006455annotation not available (122 aa)
M91_00299Transposon TX1 uncharacterized 149 kDa protein. (346 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (982 aa)
TOPBP1DNA topoisomerase 2-binding protein 1. (1521 aa)
ENSBMUP00000007008annotation not available (98 aa)
ENSBMUP00000007124annotation not available (67 aa)
LOC102284155Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
ENSBMUP00000007365annotation not available (182 aa)
LOC102282737Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (106 aa)
XRCC2DNA repair protein XRCC2. (280 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (290 aa)
ENSBMUP00000007581annotation not available (372 aa)
ABL1Tyrosine-protein kinase. (1151 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (290 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
LOC102280785Histone H2B; Belongs to the histone H2B family. (125 aa)
ENSBMUP00000008758annotation not available (214 aa)
ENSBMUP00000009019annotation not available (245 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36. (291 aa)
ENSBMUP00000009190annotation not available (103 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC102270329Histone H4. (103 aa)
M91_14726Reverse transcriptase domain-containing protein. (1305 aa)
LOC102271941Histone H4. (103 aa)
RMI1RecQ-mediated genome instability protein 1. (624 aa)
BLMBloom syndrome protein. (1430 aa)
M91_19792Histone H2B; Belongs to the histone H2B family. (126 aa)
MDC1Mediator of DNA damage checkpoint protein 1. (1065 aa)
ENSBMUP00000009984annotation not available (144 aa)
ENSBMUP00000010118annotation not available (187 aa)
LOC102284118Histone H2B; Belongs to the histone H2B family. (126 aa)
RAD52DNA repair protein RAD52-like protein. (416 aa)
LOC102274943Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
SUMO2Small ubiquitin-related modifier. (88 aa)
LOC102266324Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSBMUP00000011755annotation not available (67 aa)
M91_12762RPA_C domain-containing protein. (251 aa)
POLD1DNA polymerase delta 1, catalytic subunit. (1087 aa)
M91_13835Serine-protein kinase ATM. (319 aa)
CDK3Cell division protein kinase 3; Belongs to the protein kinase superfamily. (305 aa)
ENSBMUP00000013457annotation not available (354 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
NBNNibrin. (754 aa)
ENSBMUP00000013748annotation not available (165 aa)
M91_08851Histone H2B; Belongs to the histone H2B family. (125 aa)
SLF1Ankyrin repeat domain-containing protein 32. (1055 aa)
RFC2Replication factor C subunit 2. (352 aa)
SPIDRUncharacterized protein. (940 aa)
HERC2E3 ubiquitin-protein ligase HERC2. (4825 aa)
ENSBMUP00000015274annotation not available (359 aa)
POLKDNA polymerase kappa. (910 aa)
LOC102277538Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (88 aa)
ATRIPATR interacting protein. (784 aa)
ENSBMUP00000015761annotation not available (105 aa)
POLHDNA polymerase eta. (710 aa)
ENSBMUP00000015985annotation not available (210 aa)
LOC106700675Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
ENSBMUP00000016303annotation not available (169 aa)
ENSBMUP00000016432annotation not available (274 aa)
RFC5Replication factor C subunit 5. (339 aa)
ENSBMUP00000016464annotation not available (106 aa)
M91_02342Histone H2B; Belongs to the histone H2B family. (67 aa)
RAD51BDNA repair protein RAD51-like protein 2. (365 aa)
ANKRD11Ankyrin repeat domain-containing protein 11. (2601 aa)
BABAM2BRCA1-A complex subunit BRE. (383 aa)
EXD2Exonuclease 3'-5' domain-containing protein 2. (627 aa)
RAD51DRAD51 paralog D. (418 aa)
ENSBMUP00000017506annotation not available (141 aa)
ENSBMUP00000017560annotation not available (91 aa)
POLE4DNA polymerase epsilon subunit 4. (117 aa)
BRCA2Breast cancer 2 susceptibility protein. (3374 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (421 aa)
ENSBMUP00000018262annotation not available (138 aa)
RFC3Replication factor C subunit 3. (356 aa)
ENSBMUP00000018430annotation not available (91 aa)
ENSBMUP00000018435annotation not available (151 aa)
ENSBMUP00000018439annotation not available (91 aa)
UBBPolyubiquitin-C. (191 aa)
LOC102275363Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
M91_00314Uncharacterized protein; Belongs to the histone H2B family. (110 aa)
RAD50DNA repair protein RAD50. (1311 aa)
ENSBMUP00000019601annotation not available (673 aa)
RECQL4ATP-dependent DNA helicase Q4. (1210 aa)
GEN1Flap endonuclease GEN-like protein 1. (906 aa)
EXO1Exonuclease 1. (833 aa)
ENSBMUP00000020374annotation not available (159 aa)
M91_12052Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (139 aa)
UBA52Ubiquitin-60S ribosomal protein L40. (128 aa)
KXD1KxDL domain-containing protein. (176 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa)
RPS27AUbiquitin-small subunit ribosomal protein S27Ae. (156 aa)
ENSBMUP00000021057annotation not available (568 aa)
ENSBMUP00000021139annotation not available (351 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa)
M91_12051Uncharacterized protein. (690 aa)
ENSBMUP00000022134annotation not available (164 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSBMUP00000022649annotation not available (60 aa)
LOC102276664Histone H4-like. (103 aa)
RPA2Replication protein A2. (270 aa)
CDK2Cell division protein kinase 2; Belongs to the protein kinase superfamily. (346 aa)
RFC4Replication factor C subunit 4. (364 aa)
MEIOBUncharacterized protein. (472 aa)
RHNO1Uncharacterized protein. (241 aa)
ENSBMUP00000024154annotation not available (109 aa)
UBCPolyubiquitin-C. (305 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (379 aa)
TIMELESSProtein timeless-like protein. (1218 aa)
LOC102287406Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSBMUP00000024507annotation not available (137 aa)
UIMC1Uncharacterized protein. (225 aa)
M91_20283Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (513 aa)
SIRT6NAD-dependent deacetylase sirtuin-6. (359 aa)
WRNWerner syndrome ATP-dependent helicase. (1426 aa)
M91_19011Histone H2B; Belongs to the histone H2B family. (358 aa)
M91_01313Uncharacterized protein; Belongs to the histone H2B family. (125 aa)
RFC1Replication factor C subunit 1. (1147 aa)
ENSBMUP00000026207annotation not available (67 aa)
ENSBMUP00000026335annotation not available (569 aa)
M91_08832Uncharacterized protein; Belongs to the histone H2B family. (67 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1318 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1828 aa)
TP53BP1Tumor suppressor p53-binding protein 1. (1965 aa)
ERCC1DNA excision repair protein ERCC-1. (304 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa)
BABAM1BRISC and BRCA1 A complex member 1. (332 aa)
ENSBMUP00000027767annotation not available (379 aa)
M91_18749Histone H2B; Belongs to the histone H2B family. (118 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (328 aa)
RAD51CDNA repair protein RAD51-like protein 3. (441 aa)
LOC102274007Histone H4. (103 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
M91_06432Uncharacterized protein; Belongs to the histone H2B family. (125 aa)
RAD9ARAD9 checkpoint clamp component A. (395 aa)
ENSBMUP00000028691annotation not available (74 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
LOC102268935Histone H4. (103 aa)
XRCC3DNA repair protein XRCC3. (136 aa)
ENSBMUP00000028984annotation not available (309 aa)
ERCC4DNA repair endonuclease XPF. (916 aa)
RBBP8DNA endonuclease RBBP8. (859 aa)
ENSBMUP00000029324annotation not available (110 aa)
POLEDNA polymerase epsilon, catalytic subunit. (2285 aa)
EME1Essential meiotic structure-specific endonuclease 1. (574 aa)
M91_05906Histone domain-containing protein; Belongs to the histone H2B family. (78 aa)
ENSBMUP00000029868annotation not available (303 aa)
LOC102264829Uncharacterized protein; Belongs to the histone H2B family. (126 aa)
M91_19001BRCA1-A complex subunit RAP80. (201 aa)
BARD1BRCA1-associated RING domain protein 1. (773 aa)
PALB2PALB2_WD40 domain-containing protein. (1195 aa)
UBE2ISUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (186 aa)
POLD4DNA polymerase delta subunit 4. (178 aa)
M91_01403Reverse transcriptase domain-containing protein. (704 aa)
LOC102286916Histone H2B; Belongs to the histone H2B family. (126 aa)
SIRT7NAD-dependent deacetylase sirtuin-7. (251 aa)
ENSBMUP00000035452annotation not available (91 aa)
LOC102273005Histone H2B; Belongs to the histone H2B family. (126 aa)
SLX1ASLX1 homolog A, structure-specific endonuclease subunit. (156 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
POLD2DNA polymerase delta subunit 2. (469 aa)
ENSBMUP00000034914annotation not available (193 aa)
RAD51AP1RAD51-associated protein 1. (343 aa)
ENSBMUP00000033781annotation not available (359 aa)
LOC102277056Histone H2B type 1-H; Belongs to the histone H2B family. (125 aa)
ENSBMUP00000033482Histone H2B type 2-E-like. (125 aa)
ENSBMUP00000033262annotation not available (408 aa)
ENSBMUP00000033156annotation not available (219 aa)
M91_15771Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
ENSBMUP00000032770annotation not available (67 aa)
ENSBMUP00000032747annotation not available (67 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSBMUP00000032671annotation not available (391 aa)
ENSBMUP00000032580annotation not available (197 aa)
ENSBMUP00000032340annotation not available (67 aa)
TDRD3Tudor domain-containing protein 3. (651 aa)
RAD17Cell cycle checkpoint protein RAD17. (708 aa)
ENSBMUP00000032035annotation not available (501 aa)
M91_16901Uncharacterized protein. (521 aa)
ENSBMUP00000031804annotation not available (415 aa)
LOC102279735Serine/threonine-protein kinase Chk1. (227 aa)
LOC102282517Histone H2B subacrosomal variant; Belongs to the histone H2B family. (122 aa)
POLE3DNA polymerase epsilon subunit 3. (145 aa)
M91_15717Rad60-SLD domain-containing protein. (54 aa)
M91_01445Histone domain-containing protein; Belongs to the histone H2B family. (123 aa)
LOC102266500Serine/threonine-protein kinase Chk1. (256 aa)
PPP4R2Serine/threonine-protein phosphatase 4 regulatory subunit 2. (412 aa)
DNA2DNA replication ATP-dependent helicase Dna2. (1061 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (417 aa)
ENSBMUP00000000061annotation not available (67 aa)
ENSBMUP00000000180annotation not available (181 aa)
M91_11360Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC102276351Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC102281510Histone H4. (103 aa)
ENSBMUP00000000321annotation not available (67 aa)
ENSBMUP00000000337annotation not available (99 aa)
LOC102277188Histone H4. (103 aa)
ENSBMUP00000000398Histone H2B type 1-like. (136 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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