STRINGSTRING
SLF1 SLF1 CCNA2 CCNA2 TAF3 TAF3 TAF5 TAF5 KAT5 KAT5 LOC102270403 LOC102270403 CSNK2A2 CSNK2A2 TAF12 TAF12 TP53INP1 TP53INP1 RAD1 RAD1 HIPK1 HIPK1 NUAK1 NUAK1 CDK5 CDK5 TAF13 TAF13 STK11 STK11 LOC102276449 LOC102276449 MRE11 MRE11 TP53INP2 TP53INP2 BRIP1 BRIP1 TOPBP1 TOPBP1 M91_17576 M91_17576 HUS1 HUS1 RPA3 RPA3 ENSBMUP00000008263 ENSBMUP00000008263 RMI1 RMI1 BLM BLM PRKAG2 PRKAG2 HIPK3 HIPK3 TBPL1 TBPL1 TAF4 TAF4 PRKAA2 PRKAA2 PRKAB2 PRKAB2 M91_12762 M91_12762 M91_13835 M91_13835 TBPL2 TBPL2 CDK3 CDK3 CDK5R1 CDK5R1 RPA1 RPA1 NBN NBN RFC2 RFC2 TAF11 TAF11 MDM2 MDM2 TAF7L TAF7L DYRK2 DYRK2 ATRIP ATRIP RFC5 RFC5 TAF15 TAF15 ANKRD11 ANKRD11 TAF10 TAF10 EXD2 EXD2 M91_07424 M91_07424 M91_11796 M91_11796 MAPK14 MAPK14 ENSBMUP00000017506 ENSBMUP00000017506 CCNA1 CCNA1 RFC3 RFC3 ENSBMUP00000018435 ENSBMUP00000018435 UBB UBB CSNK2B CSNK2B LY6G5B LY6G5B RAD50 RAD50 RECQL4 RECQL4 EXO1 EXO1 TPX2 TPX2 UBA52 UBA52 KXD1 KXD1 TOP3A TOP3A RPS27A RPS27A MAPK11 MAPK11 HIPK4 HIPK4 CSNK2A1 CSNK2A1 TAF4B TAF4B AURKA AURKA SSRP1 SSRP1 PLK3 PLK3 TAF9B TAF9B HIPK2 HIPK2 TAF7 TAF7 RPA2 RPA2 CDK2 CDK2 RFC4 RFC4 MEIOB MEIOB RHNO1 RHNO1 UBC UBC MDM4 MDM4 ENSBMUP00000024454 ENSBMUP00000024454 SUPT16H SUPT16H WRN WRN BRCA1 BRCA1 ATR ATR RAD9B RAD9B RAD9A RAD9A TP53 TP53 PRKAB1 PRKAB1 PIN1 PIN1 RBBP8 RBBP8 AURKB AURKB BARD1 BARD1 DNA2 DNA2 LOC102266500 LOC102266500 PRKAG1 PRKAG1 M91_09432 M91_09432 LOC102279735 LOC102279735 TAF6 TAF6 RAD17 RAD17 TDRD3 TDRD3 NUAK2 NUAK2 ENSBMUP00000033156 ENSBMUP00000033156 TAF1 TAF1 DYRK3 DYRK3 MAPKAPK5 MAPKAPK5 NOC2L NOC2L DYRK4 DYRK4 PRKAG3 PRKAG3 CDK5R2 CDK5R2 TAF2 TAF2 TBP TBP PRKAA1 PRKAA1 AURKC AURKC CHEK2 CHEK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLF1Ankyrin repeat domain-containing protein 32. (1055 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (417 aa)
TAF3Transcription initiation factor TFIID subunit 3. (932 aa)
TAF5Transcription initiation factor TFIID subunit 5. (796 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
LOC102270403TATA-box-binding protein. (299 aa)
CSNK2A2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (350 aa)
TAF12Transcription initiation factor TFIID subunit 12. (204 aa)
TP53INP1Tumor protein p53-inducible nuclear protein 1. (240 aa)
RAD1Cell cycle checkpoint protein RAD1. (279 aa)
HIPK1Homeodomain-interacting protein kinase 1; Belongs to the protein kinase superfamily. (1242 aa)
NUAK1NUAK family SNF1-like kinase 1. (666 aa)
CDK5Cell division protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
TAF13Transcription initiation factor TFIID subunit 13. (124 aa)
STK11Serine/threonine-protein kinase 11; Belongs to the protein kinase superfamily. (438 aa)
LOC102276449Replication protein A 32 kDa subunit. (270 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
TP53INP2Tumor protein p53-inducible nuclear protein 2. (142 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (982 aa)
TOPBP1DNA topoisomerase 2-binding protein 1. (1521 aa)
M91_17576Protein kinase domain-containing protein. (278 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (290 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
ENSBMUP00000008263annotation not available (245 aa)
RMI1RecQ-mediated genome instability protein 1. (624 aa)
BLMBloom syndrome protein. (1430 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (317 aa)
HIPK3Homeodomain-interacting protein kinase 3. (1231 aa)
TBPL1TATA box-binding protein-like protein 1. (186 aa)
TAF4Transcription initiation factor TFIID subunit 4. (720 aa)
PRKAA2Non-specific serine/threonine protein kinase. (533 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
M91_12762RPA_C domain-containing protein. (251 aa)
M91_13835Serine-protein kinase ATM. (319 aa)
TBPL2TATA box-binding protein-like protein 2. (435 aa)
CDK3Cell division protein kinase 3; Belongs to the protein kinase superfamily. (305 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
NBNNibrin. (754 aa)
RFC2Replication factor C subunit 2. (352 aa)
TAF11Transcription initiation factor TFIID subunit 11. (210 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (492 aa)
TAF7LTranscription initiation factor TFIID subunit 7-like protein. (367 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2. (568 aa)
ATRIPATR interacting protein. (784 aa)
RFC5Replication factor C subunit 5. (339 aa)
TAF15TATA-binding protein-associated factor 2N. (611 aa)
ANKRD11Ankyrin repeat domain-containing protein 11. (2601 aa)
TAF10Transcription initiation factor TFIID subunit 10. (218 aa)
EXD2Exonuclease 3'-5' domain-containing protein 2. (627 aa)
M91_07424TAFII28 domain-containing protein. (198 aa)
M91_11796TFIID_20kDa domain-containing protein. (199 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
ENSBMUP00000017506annotation not available (141 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (421 aa)
RFC3Replication factor C subunit 3. (356 aa)
ENSBMUP00000018435annotation not available (151 aa)
UBBPolyubiquitin-C. (191 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)
LY6G5BUncharacterized protein. (202 aa)
RAD50DNA repair protein RAD50. (1311 aa)
RECQL4ATP-dependent DNA helicase Q4. (1210 aa)
EXO1Exonuclease 1. (833 aa)
TPX2Targeting protein for Xklp2. (747 aa)
UBA52Ubiquitin-60S ribosomal protein L40. (128 aa)
KXD1KxDL domain-containing protein. (176 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa)
RPS27AUbiquitin-small subunit ribosomal protein S27Ae. (156 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
HIPK4Homeodomain-interacting protein kinase 4. (616 aa)
CSNK2A1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
TAF4BTranscription initiation factor TFIID subunit 4B. (863 aa)
AURKASerine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (402 aa)
SSRP1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (863 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
TAF9BTranscription initiation factor TFIID subunit 9B. (254 aa)
HIPK2Homeodomain-interacting protein kinase 2. (1311 aa)
TAF7Transcription initiation factor TFIID subunit 7. (349 aa)
RPA2Replication protein A2. (270 aa)
CDK2Cell division protein kinase 2; Belongs to the protein kinase superfamily. (346 aa)
RFC4Replication factor C subunit 4. (364 aa)
MEIOBUncharacterized protein. (472 aa)
RHNO1Uncharacterized protein. (241 aa)
UBCPolyubiquitin-C. (305 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
ENSBMUP00000024454annotation not available (89 aa)
SUPT16HFACT complex subunit SPT16. (1047 aa)
WRNWerner syndrome ATP-dependent helicase. (1426 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1828 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (328 aa)
RAD9ARAD9 checkpoint clamp component A. (395 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (386 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (297 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
RBBP8DNA endonuclease RBBP8. (859 aa)
AURKBSerine/threonine-protein kinase 12; Belongs to the protein kinase superfamily. (344 aa)
BARD1BRCA1-associated RING domain protein 1. (773 aa)
DNA2DNA replication ATP-dependent helicase Dna2. (1061 aa)
LOC102266500Serine/threonine-protein kinase Chk1. (256 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (349 aa)
M91_09432Transcription initiation factor TFIID subunit 9. (286 aa)
LOC102279735Serine/threonine-protein kinase Chk1. (227 aa)
TAF6Transcription initiation factor TFIID subunit 6. (678 aa)
RAD17Cell cycle checkpoint protein RAD17. (708 aa)
TDRD3Tudor domain-containing protein 3. (651 aa)
NUAK2NUAK family SNF1-like kinase 2. (644 aa)
ENSBMUP00000033156annotation not available (219 aa)
TAF1Transcription initiation factor TFIID subunit 1. (1899 aa)
DYRK3Dual specificity tyrosine-phosphorylation-regulated kinase 3. (582 aa)
MAPKAPK5MAP kinase-activated protein kinase 5. (472 aa)
NOC2LNucleolar complex protein 2-like protein. (749 aa)
DYRK4Dual specificity tyrosine-phosphorylation-regulated kinase 4. (637 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (496 aa)
CDK5R2Cyclin dependent kinase 5 regulatory subunit 2. (101 aa)
TAF2Transcription initiation factor TFIID subunit 2. (1251 aa)
TBPTATA-box-binding protein. (312 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
AURKCAurora kinase C. (304 aa)
CHEK2Checkpoint kinase 2. (441 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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