(37 nodes) Activation of the pre-replicative complex network (Bos mutus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
	M91_12762	RPA_C domain-containing protein. (251 aa)
	CDK3	Cell division protein kinase 3; Belongs to the protein kinase superfamily. (305 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	MCM4	DNA helicase; Belongs to the MCM family. (789 aa)
	ORC6	Origin recognition complex subunit 6. (252 aa)
	ORC3	Origin recognition complex subunit 3. (712 aa)
	CDT1	DNA replication factor Cdt1. (548 aa)
	POLE4	DNA polymerase epsilon subunit 4. (117 aa)
	PRIM2	DNA primase large subunit. (464 aa)
	CDC7	Cell division control protein 7. (576 aa)
	MCM5	DNA helicase; Belongs to the MCM family. (734 aa)
	MCM8	DNA replication licensing factor MCM8; Belongs to the MCM family. (832 aa)
	POLA1	DNA polymerase. (1468 aa)
	MCM10	Protein MCM10-like protein. (871 aa)
	ORC1	Origin recognition complex subunit 1. (834 aa)
	RPA2	Replication protein A2. (270 aa)
	CDK2	Cell division protein kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	MCM2	Minichromosome maintenance complex component 2. (840 aa)
	MEIOB	Uncharacterized protein. (472 aa)
	PRIM1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
	MCM3	Minichromosome maintenance complex component 3. (808 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	DBF4	Protein DBF4-like protein A. (674 aa)
	POLE	DNA polymerase epsilon, catalytic subunit. (2285 aa)
	POLE3	DNA polymerase epsilon subunit 3. (145 aa)
	ORC5	Origin recognition complex subunit 5. (435 aa)
	MCM9	DNA replication licensing factor MCM9; Belongs to the MCM family. (1139 aa)
	ORC2	Origin recognition complex subunit 2. (576 aa)
	GMNN	Geminin. (104 aa)
	POLA2	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa)
	CDC6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
	LOC102276449	Replication protein A 32 kDa subunit. (270 aa)
	CDC45	Cell division control protein 45-like protein. (566 aa)
	MCM6	Minichromosome maintenance complex component 6. (820 aa)
	RPA3	Replication protein A 14 kDa subunit. (121 aa)
	ORC4	Origin recognition complex subunit 4. (455 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC45	CDC6	ENSBMUP00000006477	ENSBMUP00000004966	Cell division control protein 45-like protein.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.948
CDC45	CDC7	ENSBMUP00000006477	ENSBMUP00000018739	Cell division control protein 45-like protein.	Cell division control protein 7.	0.890
CDC45	CDK2	ENSBMUP00000006477	ENSBMUP00000023254	Cell division control protein 45-like protein.	Cell division protein kinase 2; Belongs to the protein kinase superfamily.	0.810
CDC45	CDK3	ENSBMUP00000006477	ENSBMUP00000012967	Cell division control protein 45-like protein.	Cell division protein kinase 3; Belongs to the protein kinase superfamily.	0.666
CDC45	CDT1	ENSBMUP00000006477	ENSBMUP00000017478	Cell division control protein 45-like protein.	DNA replication factor Cdt1.	0.970
CDC45	DBF4	ENSBMUP00000006477	ENSBMUP00000029433	Cell division control protein 45-like protein.	Protein DBF4-like protein A.	0.938
CDC45	GMNN	ENSBMUP00000006477	ENSBMUP00000001537	Cell division control protein 45-like protein.	Geminin.	0.642
CDC45	LOC102276449	ENSBMUP00000006477	ENSBMUP00000005252	Cell division control protein 45-like protein.	Replication protein A 32 kDa subunit.	0.555
CDC45	M91_12762	ENSBMUP00000006477	ENSBMUP00000012105	Cell division control protein 45-like protein.	RPA_C domain-containing protein.	0.555
CDC45	MCM10	ENSBMUP00000006477	ENSBMUP00000022012	Cell division control protein 45-like protein.	Protein MCM10-like protein.	0.998
CDC45	MCM2	ENSBMUP00000006477	ENSBMUP00000023674	Cell division control protein 45-like protein.	Minichromosome maintenance complex component 2.	0.998
CDC45	MCM3	ENSBMUP00000006477	ENSBMUP00000028362	Cell division control protein 45-like protein.	Minichromosome maintenance complex component 3.	0.996
CDC45	MCM4	ENSBMUP00000006477	ENSBMUP00000014779	Cell division control protein 45-like protein.	DNA helicase; Belongs to the MCM family.	0.998
CDC45	MCM5	ENSBMUP00000006477	ENSBMUP00000018766	Cell division control protein 45-like protein.	DNA helicase; Belongs to the MCM family.	0.997
CDC45	MCM6	ENSBMUP00000006477	ENSBMUP00000006888	Cell division control protein 45-like protein.	Minichromosome maintenance complex component 6.	0.998
CDC45	MCM7	ENSBMUP00000006477	ENSBMUP00000031706	Cell division control protein 45-like protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.996
CDC45	MCM8	ENSBMUP00000006477	ENSBMUP00000020925	Cell division control protein 45-like protein.	DNA replication licensing factor MCM8; Belongs to the MCM family.	0.948
CDC45	MCM9	ENSBMUP00000006477	ENSBMUP00000031903	Cell division control protein 45-like protein.	DNA replication licensing factor MCM9; Belongs to the MCM family.	0.958
CDC45	MEIOB	ENSBMUP00000006477	ENSBMUP00000024082	Cell division control protein 45-like protein.	Uncharacterized protein.	0.686
CDC45	ORC1	ENSBMUP00000006477	ENSBMUP00000022922	Cell division control protein 45-like protein.	Origin recognition complex subunit 1.	0.969