STRINGSTRING
FLT3 FLT3 FGF5 FGF5 FRS2 FRS2 PIK3R4 PIK3R4 ATP6V1C2 ATP6V1C2 ATP6V0E1 ATP6V0E1 FGF16 FGF16 NRDC NRDC PIK3CA PIK3CA PTPRF PTPRF ATP6V0A1 ATP6V0A1 AKT2 AKT2 ATP6V1A ATP6V1A ATP6V1G3 ATP6V1G3 ATP6V1G1 ATP6V1G1 TRIB3 TRIB3 FGFR2 FGFR2 PDPK1 PDPK1 FGF2 FGF2 KL KL ATP6V1G2 ATP6V1G2 IRS1 IRS1 ATP6V1H ATP6V1H ATP6V0A2 ATP6V0A2 GAB1 GAB1 ATP6V1B1 ATP6V1B1 ATP6V1B2 ATP6V1B2 FGF22 FGF22 FGF8 FGF8 MAPK1 MAPK1 ATP6V0B ATP6V0B FLT3LG FLT3LG ATP6V0D1 ATP6V0D1 ENSBMUP00000006145 ENSBMUP00000006145 ATP6V0A4-2 ATP6V0A4-2 TCIRG1 TCIRG1 ATP6V1E2 ATP6V1E2 FGF3 FGF3 SOS1 SOS1 SPEM2 SPEM2 SPEM1 SPEM1 PIK3CB PIK3CB FGFR4 FGFR4 ATP6AP1L ATP6AP1L TLR9 TLR9 ENSBMUP00000011052 ENSBMUP00000011052 ATP6V1E1 ATP6V1E1 GRB2 GRB2 LIM2 LIM2 PTPN11 PTPN11 ATP6V1D ATP6V1D PIK3R1 PIK3R1 CNST CNST ATP6V0E2 ATP6V0E2 ATP6V0D2 ATP6V0D2 M91_00880 M91_00880 FGFR1 FGFR1 LOC102264736 LOC102264736 SHC1 SHC1 FGF18 FGF18 PTPN1 PTPN1 GAB2 GAB2 FGF17 FGF17 ATP6AP1 ATP6AP1 ENSBMUP00000036006 ENSBMUP00000036006 AKT1 AKT1 MAPK3 MAPK3 ATP6V1C1 ATP6V1C1 INSR INSR FGF6 FGF6 PIK3R2 PIK3R2 ATP6V0A4 ATP6V0A4 THEM4 THEM4 M91_10940 M91_10940 FGF20 FGF20 IDE IDE ATP6V1F ATP6V1F FGF10 FGF10 FGF7 FGF7 PIK3C3 PIK3C3 ATP6V0C ATP6V0C LOC102285991 LOC102285991 FGFR3 FGFR3 INS INS ENSBMUP00000026546 ENSBMUP00000026546 CTSD CTSD KLB KLB FGF9 FGF9 FGF1 FGF1 ENSBMUP00000025799 ENSBMUP00000025799
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FLT3FL cytokine receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (973 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (125 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
NRDCNardilysin. (1230 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F. (1878 aa)
ATP6V0A1V-type H+-transporting ATPase subunit a. (838 aa)
AKT2RAC-beta serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ATP6V1AV-type proton ATPase catalytic subunit A. (618 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
TRIB3Tribbles-like protein 3. (357 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (566 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
KLKlotho. (1012 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (136 aa)
IRS1Insulin receptor substrate 1. (1237 aa)
ATP6V1HV-type H+-transporting ATPase subunit H. (483 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (854 aa)
GAB1GRB2-associated-binding protein 1. (724 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (310 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
MAPK1Mitogen-activated protein kinase. (332 aa)
ATP6V0BV-type proton ATPase 21 kDa proteolipid subunit; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
FLT3LGSL cytokine. (292 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
ENSBMUP00000006145annotation not available (102 aa)
ATP6V0A4-2V-type H+-transporting ATPase subunit a. (135 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (819 aa)
ATP6V1E2V-type proton ATPase subunit E 2. (226 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
SOS1Son of sevenless-like protein 1. (1333 aa)
SPEM2Spem1 domain-containing protein. (497 aa)
SPEM1Spermatid maturation protein 1. (313 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
FGFR4Fibroblast growth factor receptor. (799 aa)
ATP6AP1LV-type proton ATPase subunit S1-like protein. (278 aa)
TLR9Toll like receptor 9. (1006 aa)
ENSBMUP00000011052annotation not available (81 aa)
ATP6V1E1V-type proton ATPase subunit E 1. (226 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
LIM2Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (173 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (593 aa)
ATP6V1DV-type proton ATPase subunit D. (247 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
CNSTConsortin. (721 aa)
ATP6V0E2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
ATP6V0D2V-type proton ATPase subunit d 2. (351 aa)
M91_00880Uncharacterized protein. (74 aa)
FGFR1Basic fibroblast growth factor receptor 1. (852 aa)
LOC102264736Growth factor receptor-bound protein 10. (562 aa)
SHC1SHC-transforming protein 1. (501 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type 1. (429 aa)
GAB2GRB2-associated-binding protein 2. (666 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (460 aa)
ENSBMUP00000036006annotation not available (156 aa)
AKT1RAC serine/threonine-protein kinase. (421 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
INSRInsulin receptor. (1382 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (688 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (792 aa)
THEM4Thioesterase superfamily member 4. (237 aa)
M91_10940Tyrosine-protein phosphatase non-receptor type 11. (618 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
IDEInsulin-degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FGF7Fibroblast growth factor 7. (194 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (886 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
LOC102285991Phosphodiesterase. (626 aa)
FGFR3Fibroblast growth factor receptor 3. (788 aa)
INSInsulin. (99 aa)
ENSBMUP00000026546annotation not available (93 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (418 aa)
KLBBeta-klotho. (1016 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (195 aa)
ENSBMUP00000025799annotation not available (100 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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