(19 nodes) VLDLR internalisation and degradation network (Bos mutus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSBMUP00000017506	annotation not available (141 aa)
	AP2A1	AP-2 complex subunit alpha-1. (980 aa)
	CLTC	Clathrin heavy chain 1. (1682 aa)
	AP2S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (144 aa)
	AP2A2	AP-2 complex subunit alpha-2. (934 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (454 aa)
	MYLIP	E3 ubiquitin-protein ligase MYLIP. (380 aa)
	AP2B1	AP-1 complex subunit beta-1. (951 aa)
	UBB	Polyubiquitin-C. (191 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40. (128 aa)
	KXD1	KxDL domain-containing protein. (176 aa)
	RPS27A	Ubiquitin-small subunit ribosomal protein S27Ae. (156 aa)
	CLHC1	Clathrin heavy chain linker domain-containing protein 1. (586 aa)
	VLDLR	Very low density lipoprotein receptor. (850 aa)
	UBC	Polyubiquitin-C. (305 aa)
	AP2M1	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (459 aa)
	NR1H3	Oxysterols receptor LXR-alpha. (446 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (243 aa)
	ENSBMUP00000034311	annotation not available (241 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP2A1	AP2A2	ENSBMUP00000005794	ENSBMUP00000007025	AP-2 complex subunit alpha-1.	AP-2 complex subunit alpha-2.	0.950
AP2A1	AP2B1	ENSBMUP00000005794	ENSBMUP00000016907	AP-2 complex subunit alpha-1.	AP-1 complex subunit beta-1.	0.988
AP2A1	AP2M1	ENSBMUP00000005794	ENSBMUP00000027164	AP-2 complex subunit alpha-1.	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.998
AP2A1	AP2S1	ENSBMUP00000005794	ENSBMUP00000006573	AP-2 complex subunit alpha-1.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.999
AP2A1	CLHC1	ENSBMUP00000005794	ENSBMUP00000020868	AP-2 complex subunit alpha-1.	Clathrin heavy chain linker domain-containing protein 1.	0.784
AP2A1	CLTA	ENSBMUP00000005794	ENSBMUP00000033827	AP-2 complex subunit alpha-1.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.976
AP2A1	CLTC	ENSBMUP00000005794	ENSBMUP00000006165	AP-2 complex subunit alpha-1.	Clathrin heavy chain 1.	0.984
AP2A1	ENSBMUP00000017506	ENSBMUP00000005794	ENSBMUP00000017506	AP-2 complex subunit alpha-1.	annotation not available	0.496
AP2A1	ENSBMUP00000034311	ENSBMUP00000005794	ENSBMUP00000034311	AP-2 complex subunit alpha-1.	annotation not available	0.864
AP2A1	RPS27A	ENSBMUP00000005794	ENSBMUP00000020797	AP-2 complex subunit alpha-1.	Ubiquitin-small subunit ribosomal protein S27Ae.	0.508
AP2A1	UBB	ENSBMUP00000005794	ENSBMUP00000018689	AP-2 complex subunit alpha-1.	Polyubiquitin-C.	0.537
AP2A1	UBC	ENSBMUP00000005794	ENSBMUP00000024192	AP-2 complex subunit alpha-1.	Polyubiquitin-C.	0.537
AP2A1	VLDLR	ENSBMUP00000005794	ENSBMUP00000023506	AP-2 complex subunit alpha-1.	Very low density lipoprotein receptor.	0.506
AP2A2	AP2A1	ENSBMUP00000007025	ENSBMUP00000005794	AP-2 complex subunit alpha-2.	AP-2 complex subunit alpha-1.	0.950
AP2A2	AP2B1	ENSBMUP00000007025	ENSBMUP00000016907	AP-2 complex subunit alpha-2.	AP-1 complex subunit beta-1.	0.996
AP2A2	AP2M1	ENSBMUP00000007025	ENSBMUP00000027164	AP-2 complex subunit alpha-2.	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.995
AP2A2	AP2S1	ENSBMUP00000007025	ENSBMUP00000006573	AP-2 complex subunit alpha-2.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.999
AP2A2	CLTA	ENSBMUP00000007025	ENSBMUP00000033827	AP-2 complex subunit alpha-2.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.962
AP2A2	CLTC	ENSBMUP00000007025	ENSBMUP00000006165	AP-2 complex subunit alpha-2.	Clathrin heavy chain 1.	0.970
AP2A2	ENSBMUP00000017506	ENSBMUP00000007025	ENSBMUP00000017506	AP-2 complex subunit alpha-2.	annotation not available	0.443