(32 nodes) FLT3 Signaling network (Bos mutus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	LCK	LCK proto-oncogene, Src family tyrosine kinase. (539 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B. (198 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
	SYK	Non-specific protein-tyrosine kinase. (629 aa)
	HRAS	HRas proto-oncogene, GTPase. (182 aa)
	PIK3CA	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1072 aa)
	RPS27A	Ubiquitin-small subunit ribosomal protein S27Ae. (156 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40. (128 aa)
	CSK	Tyrosine-protein kinase. (470 aa)
	LOC102264736	Growth factor receptor-bound protein 10. (562 aa)
	CBL	E3 ubiquitin-protein ligase CBL. (906 aa)
	UBC	Polyubiquitin-C. (305 aa)
	FLT3	FL cytokine receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (973 aa)
	ABL2	ABL proto-oncogene 2, non-receptor tyrosine kinase. (1177 aa)
	UBB	Polyubiquitin-C. (191 aa)
	ENSBMUP00000017506	annotation not available (141 aa)
	GAB2	GRB2-associated-binding protein 2. (666 aa)
	PTPRJ	Receptor-type tyrosine-protein phosphatase eta. (1220 aa)
	FOXO3	Forkhead box protein O3. (453 aa)
	KRAS	GTPase KRas. (189 aa)
	SH2B3	SH2B adapter protein 3. (568 aa)
	SLA	Src like adaptor. (276 aa)
	ENSBMUP00000036006	annotation not available (156 aa)
	SLA2	Src-like-adapter 2. (276 aa)
	FLT3LG	SL cytokine. (292 aa)
	GRAP2	GRB2-related adapter protein 2. (316 aa)
	ERAS	GTPase ERas. (234 aa)
	CSDE1	Cold shock domain containing E1. (839 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	SOS1	Son of sevenless-like protein 1. (1333 aa)
	NRAS	GTPase NRas. (189 aa)

Your Current Organism:

Bos mutus

NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL2	CBL	ENSBMUP00000018836	ENSBMUP00000013771	ABL proto-oncogene 2, non-receptor tyrosine kinase.	E3 ubiquitin-protein ligase CBL.	0.716
ABL2	CDKN1B	ENSBMUP00000018836	ENSBMUP00000012122	ABL proto-oncogene 2, non-receptor tyrosine kinase.	Cyclin-dependent kinase inhibitor 1B.	0.433
ABL2	FLT3	ENSBMUP00000018836	ENSBMUP00000031063	ABL proto-oncogene 2, non-receptor tyrosine kinase.	FL cytokine receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.560
ABL2	GRAP2	ENSBMUP00000018836	ENSBMUP00000005209	ABL proto-oncogene 2, non-receptor tyrosine kinase.	GRB2-related adapter protein 2.	0.406
ABL2	GRB2	ENSBMUP00000018836	ENSBMUP00000011430	ABL proto-oncogene 2, non-receptor tyrosine kinase.	Growth factor receptor-bound protein 2.	0.634
CBL	ABL2	ENSBMUP00000013771	ENSBMUP00000018836	E3 ubiquitin-protein ligase CBL.	ABL proto-oncogene 2, non-receptor tyrosine kinase.	0.716
CBL	CSK	ENSBMUP00000013771	ENSBMUP00000019614	E3 ubiquitin-protein ligase CBL.	Tyrosine-protein kinase.	0.750
CBL	ENSBMUP00000017506	ENSBMUP00000013771	ENSBMUP00000017506	E3 ubiquitin-protein ligase CBL.	annotation not available	0.667
CBL	FLT3	ENSBMUP00000013771	ENSBMUP00000031063	E3 ubiquitin-protein ligase CBL.	FL cytokine receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.631
CBL	GRAP2	ENSBMUP00000013771	ENSBMUP00000005209	E3 ubiquitin-protein ligase CBL.	GRB2-related adapter protein 2.	0.744
CBL	GRB2	ENSBMUP00000013771	ENSBMUP00000011430	E3 ubiquitin-protein ligase CBL.	Growth factor receptor-bound protein 2.	0.998
CBL	LCK	ENSBMUP00000013771	ENSBMUP00000011545	E3 ubiquitin-protein ligase CBL.	LCK proto-oncogene, Src family tyrosine kinase.	0.814
CBL	PIK3CA	ENSBMUP00000013771	ENSBMUP00000022113	E3 ubiquitin-protein ligase CBL.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family.	0.961
CBL	PIK3R1	ENSBMUP00000013771	ENSBMUP00000012969	E3 ubiquitin-protein ligase CBL.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.997
CBL	RPS27A	ENSBMUP00000013771	ENSBMUP00000020797	E3 ubiquitin-protein ligase CBL.	Ubiquitin-small subunit ribosomal protein S27Ae.	0.838
CBL	SH2B3	ENSBMUP00000013771	ENSBMUP00000028386	E3 ubiquitin-protein ligase CBL.	SH2B adapter protein 3.	0.618
CBL	SLA	ENSBMUP00000013771	ENSBMUP00000030705	E3 ubiquitin-protein ligase CBL.	Src like adaptor.	0.745
CBL	SLA2	ENSBMUP00000013771	ENSBMUP00000001433	E3 ubiquitin-protein ligase CBL.	Src-like-adapter 2.	0.989
CBL	SOS1	ENSBMUP00000013771	ENSBMUP00000007852	E3 ubiquitin-protein ligase CBL.	Son of sevenless-like protein 1.	0.575
CBL	SYK	ENSBMUP00000013771	ENSBMUP00000013152	E3 ubiquitin-protein ligase CBL.	Non-specific protein-tyrosine kinase.	0.959