STRINGSTRING
DMRT3 DMRT3 ATP6V1C1 ATP6V1C1 DDIT3 DDIT3 CASTOR1 CASTOR1 FNIP2 FNIP2 C12orf66 C12orf66 NPRL3 NPRL3 BMT2 BMT2 WDR24 WDR24 LAMTOR4 LAMTOR4 DEPDC5 DEPDC5 SLC38A9 SLC38A9 RHEBL1 RHEBL1 ATP6V1F ATP6V1F WDR59 WDR59 DMRTB1 DMRTB1 ATP6V0C ATP6V0C M91_08538 M91_08538 METTL25 METTL25 RRAGD RRAGD GCN1 GCN1 NPRL2 NPRL2 ENSBMUP00000026546 ENSBMUP00000026546 CEBPG CEBPG ENSBMUP00000025799 ENSBMUP00000025799 ATP6V1C2 ATP6V1C2 ITFG2 ITFG2 RPTOR RPTOR LAMTOR1 LAMTOR1 SESN2 SESN2 ATP6V0E1 ATP6V0E1 MACC1 MACC1 SZT2 SZT2 SESN1 SESN1 FLCN FLCN ATP6V1A ATP6V1A ATP6V1G3 ATP6V1G3 DMRTA2 DMRTA2 MLST8 MLST8 ATP6V1G1 ATP6V1G1 TXNDC11 TXNDC11 FNIP1 FNIP1 SESN3 SESN3 RRAGA RRAGA IMPACT IMPACT LAMTOR2 LAMTOR2 ATP6V1G2 ATP6V1G2 ATP6V1H ATP6V1H CASTOR2 CASTOR2 DMRTA1 DMRTA1 M91_00880 M91_00880 ATP6V0D2 ATP6V0D2 SEH1L SEH1L ATP6V0E2 ATP6V0E2 CNST CNST LOC102266555 LOC102266555 ATP6V1D ATP6V1D LIM2 LIM2 LAMTOR3 LAMTOR3 ATP6V1E1 ATP6V1E1 ENSBMUP00000011052 ENSBMUP00000011052 RRAGB RRAGB DMRT2 DMRT2 DMRTC2 DMRTC2 M91_02843 M91_02843 ENSBMUP00000009162 ENSBMUP00000009162 SEC13 SEC13 MIOS MIOS ATF3 ATF3 PPP1R3A PPP1R3A M91_09858 M91_09858 ATP6V1E2 ATP6V1E2 TCIRG1 TCIRG1 RRAGC RRAGC KPTN KPTN ATP6V0D1 ATP6V0D1 ATP6V0B ATP6V0B LAMTOR5 LAMTOR5 M91_06276 M91_06276 ATP6V1B2 ATP6V1B2 SH3BP4 SH3BP4 ATP6V1B1 ATP6V1B1 MTOR MTOR KIAA1671 KIAA1671 CRYBB3 CRYBB3 ATF4 ATF4 EIF2AK4 EIF2AK4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DMRT3Doublesex-and mab-3-related transcription factor 3. (441 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
CASTOR1GATS-like protein 3. (369 aa)
FNIP2Folliculin-interacting protein 2. (1110 aa)
C12orf66Chromosome unknown open reading frame, human C12orf66. (443 aa)
NPRL3Nitrogen permease regulator 3-like protein. (569 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
WDR24WD repeat-containing protein 24. (790 aa)
LAMTOR4Uncharacterized protein. (128 aa)
DEPDC5DEP domain-containing protein 5. (1598 aa)
SLC38A9Solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9. (560 aa)
RHEBL1GTPase RhebL1. (183 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
WDR59WD repeat-containing protein 59. (973 aa)
DMRTB1Doublesex-and mab-3-related transcription factor B1. (185 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
M91_08538Uncharacterized protein. (91 aa)
METTL25Methyltranfer_dom domain-containing protein. (451 aa)
RRAGDRas-related GTP-binding protein D. (397 aa)
GCN1Translational activator GCN1. (2671 aa)
NPRL2Nitrogen permease regulator 2-like protein. (380 aa)
ENSBMUP00000026546annotation not available (93 aa)
CEBPGCCAAT/enhancer-binding protein gamma. (149 aa)
ENSBMUP00000025799annotation not available (100 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
ITFG2Integrin-alpha FG-GAP repeat-containing protein 2. (444 aa)
RPTORRegulatory-associated protein of mTOR. (1335 aa)
LAMTOR1Uncharacterized protein. (161 aa)
SESN2Sestrin-2. (471 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
MACC1Metastasis-associated in colon cancer protein 1. (841 aa)
SZT2Protein SZT2. (3428 aa)
SESN1Sestrin-1. (552 aa)
FLCNFolliculin. (579 aa)
ATP6V1AV-type proton ATPase catalytic subunit A. (618 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
DMRTA2Doublesex-and mab-3-related transcription factor A2. (538 aa)
MLST8Target of rapamycin complex subunit LST8. (326 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
TXNDC11Thioredoxin domain-containing protein 11. (958 aa)
FNIP1Folliculin-interacting protein 1. (1163 aa)
SESN3Sestrin-3. (492 aa)
RRAGARas-related GTP-binding protein A. (313 aa)
IMPACTProtein IMPACT. (320 aa)
LAMTOR2Mitogen-activated protein-binding protein-interacting protein. (125 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (136 aa)
ATP6V1HV-type H+-transporting ATPase subunit H. (483 aa)
CASTOR2GATS-like protein 2. (378 aa)
DMRTA1Doublesex-and mab-3-related transcription factor A1. (496 aa)
M91_00880Uncharacterized protein. (74 aa)
ATP6V0D2V-type proton ATPase subunit d 2. (351 aa)
SEH1LNucleoporin SEH1; Belongs to the WD repeat SEC13 family. (356 aa)
ATP6V0E2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
CNSTConsortin. (721 aa)
LOC102266555DM domain-containing protein. (228 aa)
ATP6V1DV-type proton ATPase subunit D. (247 aa)
LIM2Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (173 aa)
LAMTOR3Mitogen-activated protein kinase scaffold protein 1. (124 aa)
ATP6V1E1V-type proton ATPase subunit E 1. (226 aa)
ENSBMUP00000011052annotation not available (81 aa)
RRAGBRas-related GTP-binding protein B-like. (371 aa)
DMRT2Doublesex-and mab-3-related transcription factor 2. (556 aa)
DMRTC2Doublesex-and mab-3-related transcription factor C2. (369 aa)
M91_02843GTP-binding protein Rheb. (79 aa)
ENSBMUP00000009162annotation not available (89 aa)
SEC13Protein SEC13-like protein; Belongs to the WD repeat SEC13 family. (325 aa)
MIOSWD repeat-containing protein mio. (875 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3. (187 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1149 aa)
M91_09858Uncharacterized protein. (91 aa)
ATP6V1E2V-type proton ATPase subunit E 2. (226 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (819 aa)
RRAGCRas-related GTP-binding protein C. (389 aa)
KPTNKaptin. (500 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
ATP6V0BV-type proton ATPase 21 kDa proteolipid subunit; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
LAMTOR5Hepatitis B virus X-interacting protein-like protein. (91 aa)
M91_06276Uncharacterized protein. (82 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
SH3BP4SH3 domain-binding protein 4. (963 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
KIAA1671Tankyrase_bdg_C domain-containing protein. (1800 aa)
CRYBB3Beta-crystallin B3; Belongs to the beta/gamma-crystallin family. (211 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (348 aa)
EIF2AK4Eukaryotic translation initiation factor 2-alpha kinase 4. (1649 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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