STRINGSTRING
GCN1 GCN1 EIF2AK4 EIF2AK4 ATF4 ATF4 CRYBB3 CRYBB3 KIAA1671 KIAA1671 MTOR MTOR ATP6V1B1 ATP6V1B1 SH3BP4 SH3BP4 ATP6V1B2 ATP6V1B2 M91_06276 M91_06276 LAMTOR5 LAMTOR5 ATP6V0B ATP6V0B ATP6V0D1 ATP6V0D1 KPTN KPTN RRAGC RRAGC TCIRG1 TCIRG1 ATP6V1E2 ATP6V1E2 M91_09858 M91_09858 PPP1R3A PPP1R3A ATF3 ATF3 MIOS MIOS SEC13 SEC13 ENSBMUP00000009162 ENSBMUP00000009162 M91_02843 M91_02843 DMRTC2 DMRTC2 DMRT2 DMRT2 DMRT3 DMRT3 RRAGB RRAGB ENSBMUP00000011052 ENSBMUP00000011052 ATP6V1E1 ATP6V1E1 LAMTOR3 LAMTOR3 LIM2 LIM2 ATP6V1D ATP6V1D LOC102266555 LOC102266555 CNST CNST ATP6V0E2 ATP6V0E2 SEH1L SEH1L ATP6V0D2 ATP6V0D2 M91_00880 M91_00880 DMRTA1 DMRTA1 CASTOR2 CASTOR2 ATP6V1H ATP6V1H ATP6V1G2 ATP6V1G2 LAMTOR2 LAMTOR2 IMPACT IMPACT RRAGA RRAGA SESN3 SESN3 FNIP1 FNIP1 TXNDC11 TXNDC11 ATP6V1G1 ATP6V1G1 MLST8 MLST8 DMRTA2 DMRTA2 ATP6V1G3 ATP6V1G3 ATP6V1A ATP6V1A FLCN FLCN SESN1 SESN1 SZT2 SZT2 MACC1 MACC1 ATP6V0E1 ATP6V0E1 SESN2 SESN2 LAMTOR1 LAMTOR1 RPTOR RPTOR ITFG2 ITFG2 ATP6V1C2 ATP6V1C2 ENSBMUP00000025799 ENSBMUP00000025799 CEBPG CEBPG ENSBMUP00000026546 ENSBMUP00000026546 NPRL2 NPRL2 RRAGD RRAGD METTL25 METTL25 M91_08538 M91_08538 ATP6V0C ATP6V0C DMRTB1 DMRTB1 WDR59 WDR59 ATP6V1F ATP6V1F RHEBL1 RHEBL1 SLC38A9 SLC38A9 DEPDC5 DEPDC5 LAMTOR4 LAMTOR4 WDR24 WDR24 BMT2 BMT2 NPRL3 NPRL3 C12orf66 C12orf66 FNIP2 FNIP2 CASTOR1 CASTOR1 DDIT3 DDIT3 ATP6V1C1 ATP6V1C1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GCN1Translational activator GCN1. (2671 aa)
EIF2AK4Eukaryotic translation initiation factor 2-alpha kinase 4. (1649 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (348 aa)
CRYBB3Beta-crystallin B3; Belongs to the beta/gamma-crystallin family. (211 aa)
KIAA1671Tankyrase_bdg_C domain-containing protein. (1800 aa)
MTORSerine/threonine-protein kinase mTOR. (2546 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
SH3BP4SH3 domain-binding protein 4. (963 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
M91_06276Uncharacterized protein. (82 aa)
LAMTOR5Hepatitis B virus X-interacting protein-like protein. (91 aa)
ATP6V0BV-type proton ATPase 21 kDa proteolipid subunit; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
KPTNKaptin. (500 aa)
RRAGCRas-related GTP-binding protein C. (389 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (819 aa)
ATP6V1E2V-type proton ATPase subunit E 2. (226 aa)
M91_09858Uncharacterized protein. (91 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1149 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3. (187 aa)
MIOSWD repeat-containing protein mio. (875 aa)
SEC13Protein SEC13-like protein; Belongs to the WD repeat SEC13 family. (325 aa)
ENSBMUP00000009162annotation not available (89 aa)
M91_02843GTP-binding protein Rheb. (79 aa)
DMRTC2Doublesex-and mab-3-related transcription factor C2. (369 aa)
DMRT2Doublesex-and mab-3-related transcription factor 2. (556 aa)
DMRT3Doublesex-and mab-3-related transcription factor 3. (441 aa)
RRAGBRas-related GTP-binding protein B-like. (371 aa)
ENSBMUP00000011052annotation not available (81 aa)
ATP6V1E1V-type proton ATPase subunit E 1. (226 aa)
LAMTOR3Mitogen-activated protein kinase scaffold protein 1. (124 aa)
LIM2Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (173 aa)
ATP6V1DV-type proton ATPase subunit D. (247 aa)
LOC102266555DM domain-containing protein. (228 aa)
CNSTConsortin. (721 aa)
ATP6V0E2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
SEH1LNucleoporin SEH1; Belongs to the WD repeat SEC13 family. (356 aa)
ATP6V0D2V-type proton ATPase subunit d 2. (351 aa)
M91_00880Uncharacterized protein. (74 aa)
DMRTA1Doublesex-and mab-3-related transcription factor A1. (496 aa)
CASTOR2GATS-like protein 2. (378 aa)
ATP6V1HV-type H+-transporting ATPase subunit H. (483 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (136 aa)
LAMTOR2Mitogen-activated protein-binding protein-interacting protein. (125 aa)
IMPACTProtein IMPACT. (320 aa)
RRAGARas-related GTP-binding protein A. (313 aa)
SESN3Sestrin-3. (492 aa)
FNIP1Folliculin-interacting protein 1. (1163 aa)
TXNDC11Thioredoxin domain-containing protein 11. (958 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
MLST8Target of rapamycin complex subunit LST8. (326 aa)
DMRTA2Doublesex-and mab-3-related transcription factor A2. (538 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V1AV-type proton ATPase catalytic subunit A. (618 aa)
FLCNFolliculin. (579 aa)
SESN1Sestrin-1. (552 aa)
SZT2Protein SZT2. (3428 aa)
MACC1Metastasis-associated in colon cancer protein 1. (841 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
SESN2Sestrin-2. (471 aa)
LAMTOR1Uncharacterized protein. (161 aa)
RPTORRegulatory-associated protein of mTOR. (1335 aa)
ITFG2Integrin-alpha FG-GAP repeat-containing protein 2. (444 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
ENSBMUP00000025799annotation not available (100 aa)
CEBPGCCAAT/enhancer-binding protein gamma. (149 aa)
ENSBMUP00000026546annotation not available (93 aa)
NPRL2Nitrogen permease regulator 2-like protein. (380 aa)
RRAGDRas-related GTP-binding protein D. (397 aa)
METTL25Methyltranfer_dom domain-containing protein. (451 aa)
M91_08538Uncharacterized protein. (91 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
DMRTB1Doublesex-and mab-3-related transcription factor B1. (185 aa)
WDR59WD repeat-containing protein 59. (973 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
RHEBL1GTPase RhebL1. (183 aa)
SLC38A9Solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9. (560 aa)
DEPDC5DEP domain-containing protein 5. (1598 aa)
LAMTOR4Uncharacterized protein. (128 aa)
WDR24WD repeat-containing protein 24. (790 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
NPRL3Nitrogen permease regulator 3-like protein. (569 aa)
C12orf66Chromosome unknown open reading frame, human C12orf66. (443 aa)
FNIP2Folliculin-interacting protein 2. (1110 aa)
CASTOR1GATS-like protein 3. (369 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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