STRINGSTRING
NLRX1 NLRX1 RIPK2 RIPK2 LOC102278265 LOC102278265 IRAK2 IRAK2 TMEM189 TMEM189 RPS6KA5 RPS6KA5 MAPK9 MAPK9 NKIRAS1 NKIRAS1 ENSBMUP00000016464 ENSBMUP00000016464 MAP2K4 MAP2K4 FOSL2 FOSL2 PPP2R5D PPP2R5D MAPK14 MAPK14 ENSBMUP00000017506 ENSBMUP00000017506 TAB2 TAB2 DUSP7 DUSP7 PPP2R1B PPP2R1B UBB UBB RPS6KA4 RPS6KA4 ENSBMUP00000019167 ENSBMUP00000019167 NFKBIB NFKBIB IRAK1 IRAK1 LRRC14 LRRC14 MAPK7 MAPK7 ATF1 ATF1 MAPK15 MAPK15 UBA52 UBA52 KXD1 KXD1 RPS27A RPS27A MAPK11 MAPK11 LRRC31 LRRC31 LRRC34 LRRC34 M91_01211 M91_01211 LRRC71 LRRC71 SKP1-2 SKP1-2 TAB3 TAB3 MAP2K3 MAP2K3 M91_13196 M91_13196 ENSBMUP00000021670 ENSBMUP00000021670 N4BP1 N4BP1 RPS6KA1 RPS6KA1 PPP4R4 PPP4R4 NKIRAS2 NKIRAS2 MAP3K7 MAP3K7 PPP2CB PPP2CB ENSBMUP00000022382 ENSBMUP00000022382 CASP8 CASP8 PPP4R1 PPP4R1 RPS6KA3 RPS6KA3 S100B S100B FBXW11 FBXW11 CHUK CHUK RELCH RELCH DUSP6 DUSP6 UBC UBC ENSBMUP00000024784 ENSBMUP00000024784 DUSP3 DUSP3 CREB5 CREB5 NFKB1 NFKB1 MAPK8 MAPK8 MAPKAPK3 MAPKAPK3 PELI3 PELI3 RPS6KA2 RPS6KA2 ATF7 ATF7 ENSBMUP00000028583 ENSBMUP00000028583 S100A12 S100A12 NLRP6 NLRP6 MAPK10 MAPK10 LOC102276577 LOC102276577 PELI1 PELI1 LOC102274006 LOC102274006 LOC102267022 LOC102267022 LOC102267504 LOC102267504 NLRC5 NLRC5 TAB1 TAB1 IKBKB IKBKB MAP3K20 MAP3K20 ENSBMUP00000001281 ENSBMUP00000001281 TRAF2 TRAF2 RELA RELA MAP3K1 MAP3K1 NLRP9 NLRP9 NFKB2 NFKB2 PPP2CA PPP2CA SKP1 SKP1 MAPK1 MAPK1 NFKBIA NFKBIA VRK3 VRK3 LRRC74B LRRC74B UBE2N UBE2N NOD1 NOD1 FOS FOS CUL1 CUL1 DUSP4 DUSP4 KHNYN KHNYN JUN JUN TRAF6 TRAF6 MAP3K8 MAP3K8 CREB1 CREB1 APP APP TNIP2 TNIP2 ATF2 ATF2 TONSL TONSL USP18 USP18 AGER AGER MAP2K6 MAP2K6 HMGB1 HMGB1 VWC2 VWC2 PELI2 PELI2 USP14 USP14 MAPKAPK2 MAPKAPK2 LRRC74A LRRC74A NOD2 NOD2 ENSBMUP00000034660 ENSBMUP00000034660 MAP2K7 MAP2K7 ELK1 ELK1 ECSIT ECSIT MAPK3 MAPK3 LRRC45 LRRC45 FNBP4 FNBP4 IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NLRX1NLR family member X1. (973 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (539 aa)
LOC102278265Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (589 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2. (621 aa)
TMEM189Transmembrane protein 189. (193 aa)
RPS6KA5Ribosomal protein S6 kinase alpha-5. (723 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
NKIRAS1NF-kappa-B inhibitor-interacting Ras-like protein 1. (192 aa)
ENSBMUP00000016464annotation not available (106 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (410 aa)
FOSL2Fos-related antigen 2. (313 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform. (604 aa)
MAPK14Mitogen-activated protein kinase. (369 aa)
ENSBMUP00000017506annotation not available (141 aa)
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 2. (409 aa)
DUSP7Dual specificity protein phosphatase 7. (381 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (667 aa)
UBBPolyubiquitin-C. (191 aa)
RPS6KA4Ribosomal protein S6 kinase alpha-4. (773 aa)
ENSBMUP00000019167annotation not available (102 aa)
NFKBIBNF-kappa-B inhibitor beta. (357 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (640 aa)
LRRC14Leucine-rich repeat-containing protein 14. (493 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (782 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1. (412 aa)
MAPK15Mitogen-activated protein kinase 15. (575 aa)
UBA52Ubiquitin-60S ribosomal protein L40. (128 aa)
KXD1KxDL domain-containing protein. (176 aa)
RPS27AUbiquitin-small subunit ribosomal protein S27Ae. (156 aa)
MAPK11Mitogen-activated protein kinase 11. (256 aa)
LRRC31Leucine rich repeat containing 31. (555 aa)
LRRC34Leucine-rich repeat-containing protein 34. (451 aa)
M91_01211TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa)
LRRC71Uncharacterized protein. (560 aa)
SKP1-2S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (717 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
M91_13196Uncharacterized protein. (663 aa)
ENSBMUP00000021670annotation not available (150 aa)
N4BP1NEDD4-binding protein 1. (861 aa)
RPS6KA1Ribosomal protein S6 kinase. (844 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (873 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2. (191 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PPP2CBSerine/threonine-protein phosphatase. (283 aa)
ENSBMUP00000022382Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like. (273 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (485 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (929 aa)
RPS6KA3Ribosomal protein S6 kinase alpha-3. (712 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
FBXW11F-box/WD repeat-containing protein 11. (531 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (740 aa)
RELCHLisH domain and HEAT repeat-containing protein KIAA1468. (1205 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
UBCPolyubiquitin-C. (305 aa)
ENSBMUP00000024784annotation not available (153 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (117 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (508 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (973 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAPKAPK3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
RPS6KA2Ribosomal protein S6 kinase A2. (704 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7. (483 aa)
ENSBMUP00000028583annotation not available (70 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6. (877 aa)
MAPK10Mitogen-activated protein kinase. (370 aa)
LOC102276577Serum amyloid A protein-like. (131 aa)
PELI1Protein pellino-like protein 1. (418 aa)
LOC102274006Serum amyloid A protein-like. (123 aa)
LOC102267022Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (181 aa)
LOC102267504Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (131 aa)
NLRC5Protein NLRC5. (1862 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (504 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase MLT. (800 aa)
ENSBMUP00000001281annotation not available (293 aa)
TRAF2TNF receptor associated factor 2. (311 aa)
RELATranscription factor p65. (549 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1509 aa)
NLRP9NACHT, LRR and PYD domains-containing protein 9. (939 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (900 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SKP1Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (161 aa)
MAPK1Mitogen-activated protein kinase. (332 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
VRK3Serine/threonine-protein kinase VRK3. (451 aa)
LRRC74BUncharacterized protein. (386 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (954 aa)
FOSProto-oncogene c-Fos. (380 aa)
CUL1Cullin-1; Belongs to the cullin family. (730 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
KHNYNProtein KHNYN. (676 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (468 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
APPAmyloid beta A4 protein. (652 aa)
TNIP2TNFAIP3 interacting protein 2. (256 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2. (505 aa)
TONSLNF-kappa-B inhibitor-like protein 2. (1373 aa)
USP18Ubl carboxyl-terminal hydrolase 18. (321 aa)
AGERAdvanced glycosylation end-product specific receptor. (416 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
HMGB1High mobility group protein B1. (215 aa)
VWC2Brorin. (325 aa)
PELI2Protein pellino-like protein 2. (420 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (494 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
LRRC74AUncharacterized protein. (487 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
ENSBMUP00000034660annotation not available (127 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
ELK1ETS domain-containing protein Elk-1. (440 aa)
ECSITEvolutionarily conserved signaling intermediate in Toll pathway, mitochondrial. (432 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (377 aa)
LRRC45Leucine-rich repeat-containing protein 45. (666 aa)
FNBP4Formin-binding protein 4. (1004 aa)
IKBKGNF-kappa-B essential modulator. (419 aa)
Your Current Organism:
Bos mutus
NCBI taxonomy Id: 72004
Other names: B. mutus, Bos grunniens mutus, Poephagus mutus, wild yak
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